Human mesenchymal stem cells
Mesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their self‐renewal capacity, multipotency and potent immunomodulatory effects on immune cells. However, heterogeneity of MSCs has become a prominent obstacle to limit their translation into pr...
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| Veröffentlicht in: | Cell proliferation 2022-04, Vol.55 (4), p.e13141-n/a |
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| creator | Chen, Xiaoyong Huang, Jing Wu, Jun Hao, Jie Fu, Boqiang Wang, Ying Zhou, Bo Na, Tao Wei, Jun Zhang, Yong Li, Qiyuan Hu, Shijun Zhou, Jiaxi Yu, Junying Wu, Zhaohui Zhu, Huanxin Cao, Jiani Wang, Lei Peng, Yaojin Liang, Lingmin Ma, Aijin Zhang, Yu Zhao, Tongbiao Xiang, Andy Peng |
| description | Mesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their self‐renewal capacity, multipotency and potent immunomodulatory effects on immune cells. However, heterogeneity of MSCs has become a prominent obstacle to limit their translation into practice, as cells from different tissue sources or each individual have great differences in their transcriptomic signatures, differentiation potential and biological functions. Therefore, there is an urgent need for consensus standard for the quality control and technical specifications of MSCs. ‘Human Mesenchymal Stem Cells’ is the latest set of guidelines on hMSC in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements, storage requirements, transportation requirements and waste disposal requirements for hMSC, which is applicable to the quality control for hMSC. It was originally released by the China Society for Cell Biology on 9 January 2021. We hope that publication of these guidelines will facilitate institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of hMSC for clinical development and therapeutic applications. |
| doi_str_mv | 10.1111/cpr.13141 |
| format | Article |
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However, heterogeneity of MSCs has become a prominent obstacle to limit their translation into practice, as cells from different tissue sources or each individual have great differences in their transcriptomic signatures, differentiation potential and biological functions. Therefore, there is an urgent need for consensus standard for the quality control and technical specifications of MSCs. ‘Human Mesenchymal Stem Cells’ is the latest set of guidelines on hMSC in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements, storage requirements, transportation requirements and waste disposal requirements for hMSC, which is applicable to the quality control for hMSC. It was originally released by the China Society for Cell Biology on 9 January 2021. We hope that publication of these guidelines will facilitate institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of hMSC for clinical development and therapeutic applications.</description><identifier>ISSN: 0960-7722</identifier><identifier>EISSN: 1365-2184</identifier><identifier>DOI: 10.1111/cpr.13141</identifier><identifier>PMID: 34936710</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Acquired immune deficiency syndrome ; Adipocytes ; AIDS ; Cell Differentiation ; Cell growth ; Cell self-renewal ; Cell therapy ; Cell- and Tissue-Based Therapy ; China ; Cryopreservation ; Fibroblasts ; Gene expression ; Guidelines ; Hepatitis B ; Hepatitis C ; Heterogeneity ; HIV ; Human immunodeficiency virus ; Humans ; Immune system ; Immunomodulation ; Labeling ; Medical laboratories ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells ; Microorganisms ; Morphology ; Packaging ; Process controls ; Quality control ; Quality standards ; Regeneration (physiology) ; Standardization ; Stem cells ; Storage requirements ; Test methods ; Therapeutic applications ; Tissue engineering ; Transcriptomics ; Tumor necrosis factor-TNF ; Tumorigenesis ; Umbilical cord ; Waste disposal</subject><ispartof>Cell proliferation, 2022-04, Vol.55 (4), p.e13141-n/a</ispartof><rights>2021 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2021 The Authors. Cell Proliferation published by John Wiley & Sons Ltd.</rights><rights>2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4431-6948b3c856b9e04af52e93eacc7ae432a6b8926c4fe7e92337930b9579c71e673</citedby><cites>FETCH-LOGICAL-c4431-6948b3c856b9e04af52e93eacc7ae432a6b8926c4fe7e92337930b9579c71e673</cites><orcidid>0000-0003-1429-5818 ; 0000-0003-3409-5012 ; 0000-0002-7739-1850 ; 0000-0002-0068-8429 ; 0000-0002-3909-6041</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055891/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055891/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11561,27923,27924,45573,45574,46051,46475,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34936710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Xiaoyong</creatorcontrib><creatorcontrib>Huang, Jing</creatorcontrib><creatorcontrib>Wu, Jun</creatorcontrib><creatorcontrib>Hao, Jie</creatorcontrib><creatorcontrib>Fu, Boqiang</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Zhou, Bo</creatorcontrib><creatorcontrib>Na, Tao</creatorcontrib><creatorcontrib>Wei, Jun</creatorcontrib><creatorcontrib>Zhang, Yong</creatorcontrib><creatorcontrib>Li, Qiyuan</creatorcontrib><creatorcontrib>Hu, Shijun</creatorcontrib><creatorcontrib>Zhou, Jiaxi</creatorcontrib><creatorcontrib>Yu, Junying</creatorcontrib><creatorcontrib>Wu, Zhaohui</creatorcontrib><creatorcontrib>Zhu, Huanxin</creatorcontrib><creatorcontrib>Cao, Jiani</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Peng, Yaojin</creatorcontrib><creatorcontrib>Liang, Lingmin</creatorcontrib><creatorcontrib>Ma, Aijin</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Zhao, Tongbiao</creatorcontrib><creatorcontrib>Xiang, Andy Peng</creatorcontrib><title>Human mesenchymal stem cells</title><title>Cell proliferation</title><addtitle>Cell Prolif</addtitle><description>Mesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their self‐renewal capacity, multipotency and potent immunomodulatory effects on immune cells. However, heterogeneity of MSCs has become a prominent obstacle to limit their translation into practice, as cells from different tissue sources or each individual have great differences in their transcriptomic signatures, differentiation potential and biological functions. Therefore, there is an urgent need for consensus standard for the quality control and technical specifications of MSCs. ‘Human Mesenchymal Stem Cells’ is the latest set of guidelines on hMSC in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements, storage requirements, transportation requirements and waste disposal requirements for hMSC, which is applicable to the quality control for hMSC. It was originally released by the China Society for Cell Biology on 9 January 2021. We hope that publication of these guidelines will facilitate institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of hMSC for clinical development and therapeutic applications.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adipocytes</subject><subject>AIDS</subject><subject>Cell Differentiation</subject><subject>Cell growth</subject><subject>Cell self-renewal</subject><subject>Cell therapy</subject><subject>Cell- and Tissue-Based Therapy</subject><subject>China</subject><subject>Cryopreservation</subject><subject>Fibroblasts</subject><subject>Gene expression</subject><subject>Guidelines</subject><subject>Hepatitis B</subject><subject>Hepatitis C</subject><subject>Heterogeneity</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunomodulation</subject><subject>Labeling</subject><subject>Medical laboratories</subject><subject>Mesenchymal Stem Cell Transplantation</subject><subject>Mesenchymal Stem Cells</subject><subject>Microorganisms</subject><subject>Morphology</subject><subject>Packaging</subject><subject>Process controls</subject><subject>Quality control</subject><subject>Quality standards</subject><subject>Regeneration (physiology)</subject><subject>Standardization</subject><subject>Stem cells</subject><subject>Storage requirements</subject><subject>Test methods</subject><subject>Therapeutic applications</subject><subject>Tissue engineering</subject><subject>Transcriptomics</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumorigenesis</subject><subject>Umbilical cord</subject><subject>Waste 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mesenchymal stem cells</title><author>Chen, Xiaoyong ; Huang, Jing ; Wu, Jun ; Hao, Jie ; Fu, Boqiang ; Wang, Ying ; Zhou, Bo ; Na, Tao ; Wei, Jun ; Zhang, Yong ; Li, Qiyuan ; Hu, Shijun ; Zhou, Jiaxi ; Yu, Junying ; Wu, Zhaohui ; Zhu, Huanxin ; Cao, Jiani ; Wang, Lei ; Peng, Yaojin ; Liang, Lingmin ; Ma, Aijin ; Zhang, Yu ; Zhao, Tongbiao ; Xiang, Andy Peng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4431-6948b3c856b9e04af52e93eacc7ae432a6b8926c4fe7e92337930b9579c71e673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adipocytes</topic><topic>AIDS</topic><topic>Cell Differentiation</topic><topic>Cell growth</topic><topic>Cell self-renewal</topic><topic>Cell therapy</topic><topic>Cell- and Tissue-Based Therapy</topic><topic>China</topic><topic>Cryopreservation</topic><topic>Fibroblasts</topic><topic>Gene expression</topic><topic>Guidelines</topic><topic>Hepatitis B</topic><topic>Hepatitis C</topic><topic>Heterogeneity</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunomodulation</topic><topic>Labeling</topic><topic>Medical laboratories</topic><topic>Mesenchymal Stem Cell Transplantation</topic><topic>Mesenchymal Stem Cells</topic><topic>Microorganisms</topic><topic>Morphology</topic><topic>Packaging</topic><topic>Process controls</topic><topic>Quality control</topic><topic>Quality standards</topic><topic>Regeneration (physiology)</topic><topic>Standardization</topic><topic>Stem cells</topic><topic>Storage requirements</topic><topic>Test methods</topic><topic>Therapeutic applications</topic><topic>Tissue engineering</topic><topic>Transcriptomics</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumorigenesis</topic><topic>Umbilical cord</topic><topic>Waste disposal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Xiaoyong</creatorcontrib><creatorcontrib>Huang, Jing</creatorcontrib><creatorcontrib>Wu, Jun</creatorcontrib><creatorcontrib>Hao, Jie</creatorcontrib><creatorcontrib>Fu, Boqiang</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Zhou, Bo</creatorcontrib><creatorcontrib>Na, Tao</creatorcontrib><creatorcontrib>Wei, Jun</creatorcontrib><creatorcontrib>Zhang, Yong</creatorcontrib><creatorcontrib>Li, Qiyuan</creatorcontrib><creatorcontrib>Hu, Shijun</creatorcontrib><creatorcontrib>Zhou, Jiaxi</creatorcontrib><creatorcontrib>Yu, Junying</creatorcontrib><creatorcontrib>Wu, Zhaohui</creatorcontrib><creatorcontrib>Zhu, Huanxin</creatorcontrib><creatorcontrib>Cao, Jiani</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Peng, Yaojin</creatorcontrib><creatorcontrib>Liang, Lingmin</creatorcontrib><creatorcontrib>Ma, Aijin</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Zhao, Tongbiao</creatorcontrib><creatorcontrib>Xiang, Andy Peng</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science 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proliferation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Xiaoyong</au><au>Huang, Jing</au><au>Wu, Jun</au><au>Hao, Jie</au><au>Fu, Boqiang</au><au>Wang, Ying</au><au>Zhou, Bo</au><au>Na, Tao</au><au>Wei, Jun</au><au>Zhang, Yong</au><au>Li, Qiyuan</au><au>Hu, Shijun</au><au>Zhou, Jiaxi</au><au>Yu, Junying</au><au>Wu, Zhaohui</au><au>Zhu, Huanxin</au><au>Cao, Jiani</au><au>Wang, Lei</au><au>Peng, Yaojin</au><au>Liang, Lingmin</au><au>Ma, Aijin</au><au>Zhang, Yu</au><au>Zhao, Tongbiao</au><au>Xiang, Andy Peng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human mesenchymal stem cells</atitle><jtitle>Cell proliferation</jtitle><addtitle>Cell Prolif</addtitle><date>2022-04</date><risdate>2022</risdate><volume>55</volume><issue>4</issue><spage>e13141</spage><epage>n/a</epage><pages>e13141-n/a</pages><issn>0960-7722</issn><eissn>1365-2184</eissn><abstract>Mesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their self‐renewal capacity, multipotency and potent immunomodulatory effects on immune cells. However, heterogeneity of MSCs has become a prominent obstacle to limit their translation into practice, as cells from different tissue sources or each individual have great differences in their transcriptomic signatures, differentiation potential and biological functions. Therefore, there is an urgent need for consensus standard for the quality control and technical specifications of MSCs. ‘Human Mesenchymal Stem Cells’ is the latest set of guidelines on hMSC in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements, storage requirements, transportation requirements and waste disposal requirements for hMSC, which is applicable to the quality control for hMSC. It was originally released by the China Society for Cell Biology on 9 January 2021. We hope that publication of these guidelines will facilitate institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of hMSC for clinical development and therapeutic applications.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>34936710</pmid><doi>10.1111/cpr.13141</doi><tpages>0</tpages><orcidid>https://orcid.org/0000-0003-1429-5818</orcidid><orcidid>https://orcid.org/0000-0003-3409-5012</orcidid><orcidid>https://orcid.org/0000-0002-7739-1850</orcidid><orcidid>https://orcid.org/0000-0002-0068-8429</orcidid><orcidid>https://orcid.org/0000-0002-3909-6041</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0960-7722 |
| ispartof | Cell proliferation, 2022-04, Vol.55 (4), p.e13141-n/a |
| issn | 0960-7722 1365-2184 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley-Blackwell Open Access Titles; Wiley Online Library All Journals; PubMed Central |
| subjects | Acquired immune deficiency syndrome Adipocytes AIDS Cell Differentiation Cell growth Cell self-renewal Cell therapy Cell- and Tissue-Based Therapy China Cryopreservation Fibroblasts Gene expression Guidelines Hepatitis B Hepatitis C Heterogeneity HIV Human immunodeficiency virus Humans Immune system Immunomodulation Labeling Medical laboratories Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells Microorganisms Morphology Packaging Process controls Quality control Quality standards Regeneration (physiology) Standardization Stem cells Storage requirements Test methods Therapeutic applications Tissue engineering Transcriptomics Tumor necrosis factor-TNF Tumorigenesis Umbilical cord Waste disposal |
| title | Human mesenchymal stem cells |
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