Metabolic Syndrome in Post-Pulmonary Tuberculosis-Associated Obstructive Airway Disease: A Cross-Sectional Analytical Study
Background The aim of this study is to assess the prevalence of metabolic syndrome in tuberculosis-associated obstructive airway disease (TOPD) patients, as well as the association of its components with the severity of airflow obstruction. Methodology In this cross-sectional analytical study, we ev...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-03, Vol.14 (3), p.e23640-e23640 |
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| creator | Mp, Shahana Mohanty Mohapatra, Madhusmita Mahesh Babu, Vemuri Rajaram, Manju Rajaa, Sathish Gandhipuram Periyasamy, Senthil Kumar |
| description | Background The aim of this study is to assess the prevalence of metabolic syndrome in tuberculosis-associated obstructive airway disease (TOPD) patients, as well as the association of its components with the severity of airflow obstruction. Methodology In this cross-sectional analytical study, we evaluated the clinical profile, spirometry, waist circumference, blood pressure, lipid profile, fasting plasma glucose, and the association of each component with the severity of airflow obstruction. Results The prevalence of metabolic syndrome in TOPD was found to be was 25.77% (95% confidence interval = 18.11-35.28) among study participants. Reduced high-density lipoprotein was the deranged component and was associated with increased severity in Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage II compared to GOLD stage IV. Conclusions The prevalence of metabolic syndrome in TOPD has a severe impact on patients' treatment, outcomes, and complications. However, in our study, tuberculosis-associated metabolic syndrome was the same as the general population. Low high-density lipoprotein levels were associated with the severity of the airflow obstruction. |
| doi_str_mv | 10.7759/cureus.23640 |
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Methodology In this cross-sectional analytical study, we evaluated the clinical profile, spirometry, waist circumference, blood pressure, lipid profile, fasting plasma glucose, and the association of each component with the severity of airflow obstruction. Results The prevalence of metabolic syndrome in TOPD was found to be was 25.77% (95% confidence interval = 18.11-35.28) among study participants. Reduced high-density lipoprotein was the deranged component and was associated with increased severity in Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage II compared to GOLD stage IV. Conclusions The prevalence of metabolic syndrome in TOPD has a severe impact on patients' treatment, outcomes, and complications. However, in our study, tuberculosis-associated metabolic syndrome was the same as the general population. Low high-density lipoprotein levels were associated with the severity of the airflow obstruction.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.23640</identifier><identifier>PMID: 35505740</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Age ; Biomass energy ; Blood pressure ; Chronic obstructive pulmonary disease ; Diabetes ; Endocrinology/Diabetes/Metabolism ; Gender ; Infectious Disease ; Lung diseases ; Males ; Metabolic syndrome ; Mortality ; Obesity ; Older people ; Pulmonology ; Smoking ; Spirometry ; Tuberculosis</subject><ispartof>Curēus (Palo Alto, CA), 2022-03, Vol.14 (3), p.e23640-e23640</ispartof><rights>Copyright © 2022, MP et al.</rights><rights>Copyright © 2022, MP et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022, MP et al. 2022 MP et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-749af61783ca6ee3feefcfbd88977e63485f1ba1076f8852a84cab5f3c526db43</citedby><cites>FETCH-LOGICAL-c342t-749af61783ca6ee3feefcfbd88977e63485f1ba1076f8852a84cab5f3c526db43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051989/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051989/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35505740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mp, Shahana</creatorcontrib><creatorcontrib>Mohanty Mohapatra, Madhusmita</creatorcontrib><creatorcontrib>Mahesh Babu, Vemuri</creatorcontrib><creatorcontrib>Rajaram, Manju</creatorcontrib><creatorcontrib>Rajaa, Sathish</creatorcontrib><creatorcontrib>Gandhipuram Periyasamy, Senthil Kumar</creatorcontrib><title>Metabolic Syndrome in Post-Pulmonary Tuberculosis-Associated Obstructive Airway Disease: A Cross-Sectional Analytical Study</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Background The aim of this study is to assess the prevalence of metabolic syndrome in tuberculosis-associated obstructive airway disease (TOPD) patients, as well as the association of its components with the severity of airflow obstruction. Methodology In this cross-sectional analytical study, we evaluated the clinical profile, spirometry, waist circumference, blood pressure, lipid profile, fasting plasma glucose, and the association of each component with the severity of airflow obstruction. Results The prevalence of metabolic syndrome in TOPD was found to be was 25.77% (95% confidence interval = 18.11-35.28) among study participants. Reduced high-density lipoprotein was the deranged component and was associated with increased severity in Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage II compared to GOLD stage IV. Conclusions The prevalence of metabolic syndrome in TOPD has a severe impact on patients' treatment, outcomes, and complications. However, in our study, tuberculosis-associated metabolic syndrome was the same as the general population. Low high-density lipoprotein levels were associated with the severity of the airflow obstruction.</description><subject>Age</subject><subject>Biomass energy</subject><subject>Blood pressure</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Diabetes</subject><subject>Endocrinology/Diabetes/Metabolism</subject><subject>Gender</subject><subject>Infectious Disease</subject><subject>Lung diseases</subject><subject>Males</subject><subject>Metabolic syndrome</subject><subject>Mortality</subject><subject>Obesity</subject><subject>Older people</subject><subject>Pulmonology</subject><subject>Smoking</subject><subject>Spirometry</subject><subject>Tuberculosis</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkU1rFTEUhgdRbKnduZaAGxedmpl8jgthuGoVKi3cug6ZzImmzExqPiqDf97c3lqqm-TAeXjJm6eqXjb4VAjWvTU5QI6nLeEUP6kO24bLWjaSPn00H1THMV5jjBssWizw8-qAMIaZoPiw-v0Vkh785AzarssY_AzILejSx1Rf5mn2iw4rusoDBJMnH12s-xi9cTrBiC6GmEI2yd0C6l34pVf0wUXQEd6hHm2Cj7HeQtmXmAn15ViTM2XcpjyuL6pnVk8Rju_vo-rbp49Xm8_1-cXZl01_XhtC21QL2mnLGyGJ0RyAWABr7DBK2QkBnFDJbDPo0o5bKVmrJTV6YJYY1vJxoOSoer_PvcnDDKOBJQU9qZvg5lJOee3Uv5vF_VDf_a3qMGs62ZWAN_cBwf_MEJOaXTQwTXoBn6NqOes4ph1lBX39H3rtcyjFd5QoNjDFuFAne8rsviiAfXhMg9VOrNqLVXdiC_7qcYEH-K9G8gd_5aLa</recordid><startdate>20220330</startdate><enddate>20220330</enddate><creator>Mp, Shahana</creator><creator>Mohanty Mohapatra, Madhusmita</creator><creator>Mahesh Babu, Vemuri</creator><creator>Rajaram, Manju</creator><creator>Rajaa, Sathish</creator><creator>Gandhipuram Periyasamy, Senthil Kumar</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220330</creationdate><title>Metabolic Syndrome in Post-Pulmonary Tuberculosis-Associated Obstructive Airway Disease: A Cross-Sectional Analytical Study</title><author>Mp, Shahana ; Mohanty Mohapatra, Madhusmita ; Mahesh Babu, Vemuri ; Rajaram, Manju ; Rajaa, Sathish ; Gandhipuram Periyasamy, Senthil Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-749af61783ca6ee3feefcfbd88977e63485f1ba1076f8852a84cab5f3c526db43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Biomass energy</topic><topic>Blood pressure</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Diabetes</topic><topic>Endocrinology/Diabetes/Metabolism</topic><topic>Gender</topic><topic>Infectious Disease</topic><topic>Lung diseases</topic><topic>Males</topic><topic>Metabolic syndrome</topic><topic>Mortality</topic><topic>Obesity</topic><topic>Older people</topic><topic>Pulmonology</topic><topic>Smoking</topic><topic>Spirometry</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mp, Shahana</creatorcontrib><creatorcontrib>Mohanty Mohapatra, Madhusmita</creatorcontrib><creatorcontrib>Mahesh Babu, Vemuri</creatorcontrib><creatorcontrib>Rajaram, Manju</creatorcontrib><creatorcontrib>Rajaa, Sathish</creatorcontrib><creatorcontrib>Gandhipuram Periyasamy, Senthil Kumar</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mp, Shahana</au><au>Mohanty Mohapatra, Madhusmita</au><au>Mahesh Babu, Vemuri</au><au>Rajaram, Manju</au><au>Rajaa, Sathish</au><au>Gandhipuram Periyasamy, Senthil Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic Syndrome in Post-Pulmonary Tuberculosis-Associated Obstructive Airway Disease: A Cross-Sectional Analytical Study</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2022-03-30</date><risdate>2022</risdate><volume>14</volume><issue>3</issue><spage>e23640</spage><epage>e23640</epage><pages>e23640-e23640</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Background The aim of this study is to assess the prevalence of metabolic syndrome in tuberculosis-associated obstructive airway disease (TOPD) patients, as well as the association of its components with the severity of airflow obstruction. Methodology In this cross-sectional analytical study, we evaluated the clinical profile, spirometry, waist circumference, blood pressure, lipid profile, fasting plasma glucose, and the association of each component with the severity of airflow obstruction. Results The prevalence of metabolic syndrome in TOPD was found to be was 25.77% (95% confidence interval = 18.11-35.28) among study participants. Reduced high-density lipoprotein was the deranged component and was associated with increased severity in Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage II compared to GOLD stage IV. Conclusions The prevalence of metabolic syndrome in TOPD has a severe impact on patients' treatment, outcomes, and complications. However, in our study, tuberculosis-associated metabolic syndrome was the same as the general population. Low high-density lipoprotein levels were associated with the severity of the airflow obstruction.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>35505740</pmid><doi>10.7759/cureus.23640</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Age Biomass energy Blood pressure Chronic obstructive pulmonary disease Diabetes Endocrinology/Diabetes/Metabolism Gender Infectious Disease Lung diseases Males Metabolic syndrome Mortality Obesity Older people Pulmonology Smoking Spirometry Tuberculosis |
| title | Metabolic Syndrome in Post-Pulmonary Tuberculosis-Associated Obstructive Airway Disease: A Cross-Sectional Analytical Study |
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