Psychosocial Interventions to Promote Undetectable HIV Viral Loads: A Systematic Review of Randomized Clinical Trials
Suppressing HIV viral loads to undetectable levels is essential for ending the HIV/AIDS epidemic. We evaluated randomized controlled trials aimed to increase antiretroviral medication adherence and promote undetectable viral loads among people living with HIV through November 22, 2019. We extracted...
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| Veröffentlicht in: | AIDS and behavior 2022-06, Vol.26 (6), p.1853-1862 |
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| creator | Toegel, Forrest Rodewald, Andrew M. Novak, Matthew D. Pollock, Sarah Arellano, Meghan Leoutsakos, Jeannie-Marie Holtyn, August F. Silverman, Kenneth |
| description | Suppressing HIV viral loads to undetectable levels is essential for ending the HIV/AIDS epidemic. We evaluated randomized controlled trials aimed to increase antiretroviral medication adherence and promote undetectable viral loads among people living with HIV through November 22, 2019. We extracted data from 51 eligible interventions and analyzed the results using random effects models to compare intervention effects between groups within each intervention and across interventions. We also evaluated the relation between publication date and treatment effects. Only five interventions increased undetectable viral loads significantly. As a whole, the analyzed interventions were superior to Standard of Care in promoting undetectable viral loads. Interventions published more recently were not more effective in promoting undetectable viral loads. No treatment category consistently produced significant increases in undetectable viral loads. To end the HIV/AIDS epidemic, we should use interventions that can suppress HIV viral loads to undetectable levels. |
| doi_str_mv | 10.1007/s10461-021-03534-z |
| format | Article |
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To end the HIV/AIDS epidemic, we should use interventions that can suppress HIV viral loads to undetectable levels.</description><identifier>ISSN: 1090-7165</identifier><identifier>ISSN: 1573-3254</identifier><identifier>EISSN: 1573-3254</identifier><identifier>DOI: 10.1007/s10461-021-03534-z</identifier><identifier>PMID: 34783938</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - drug therapy ; AIDS ; Anti-Retroviral Agents - therapeutic use ; Antiretroviral agents ; Antiretroviral drugs ; Clinical trials ; Disease control ; Epidemics ; Health behavior ; Health Psychology ; HIV ; HIV Infections - epidemiology ; Human immunodeficiency virus ; Humans ; Infectious Diseases ; Intervention ; Medical research ; Medication Adherence ; Medicine ; Medicine & Public Health ; Patient compliance ; Prescription drugs ; Psychosocial Intervention ; Public Health ; Random effects ; Randomized Controlled Trials as Topic ; Substantive Review ; Systematic review ; Viral Load</subject><ispartof>AIDS and behavior, 2022-06, Vol.26 (6), p.1853-1862</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. 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We evaluated randomized controlled trials aimed to increase antiretroviral medication adherence and promote undetectable viral loads among people living with HIV through November 22, 2019. We extracted data from 51 eligible interventions and analyzed the results using random effects models to compare intervention effects between groups within each intervention and across interventions. We also evaluated the relation between publication date and treatment effects. Only five interventions increased undetectable viral loads significantly. As a whole, the analyzed interventions were superior to Standard of Care in promoting undetectable viral loads. Interventions published more recently were not more effective in promoting undetectable viral loads. No treatment category consistently produced significant increases in undetectable viral loads. 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| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - drug therapy AIDS Anti-Retroviral Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Clinical trials Disease control Epidemics Health behavior Health Psychology HIV HIV Infections - epidemiology Human immunodeficiency virus Humans Infectious Diseases Intervention Medical research Medication Adherence Medicine Medicine & Public Health Patient compliance Prescription drugs Psychosocial Intervention Public Health Random effects Randomized Controlled Trials as Topic Substantive Review Systematic review Viral Load |
| title | Psychosocial Interventions to Promote Undetectable HIV Viral Loads: A Systematic Review of Randomized Clinical Trials |
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