Cellular uptake of 2‐aminopyridine‐modified peptide nucleic acids conjugated with cell‐penetrating peptides

Cell‐penetrating peptides (CPPs) have been extensively used to deliver peptide nucleic acid (PNA) in cells. We have previously found that replacement of cytosine in triplex‐forming PNAs with 2‐aminopyridine (M) not only enhanced RNA binding, but also improved cellular uptake of PNAs. In this study,...

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Veröffentlicht in:	Biopolymers 2022-04, Vol.113 (4), p.e23484-n/a
Hauptverfasser:	Brodyagin, Nikita, Kataoka, Yuka, Kumpina, Ilze, McGee, Dennis W., Rozners, Eriks
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyridines Arginine Calcium chloride Cell-Penetrating Peptides cellular uptake Chloroquine confocal fluorescence microscopy Conjugates Conjugation Cytoplasm Cytosine Endosomes Fluorescence Fluorescence microscopy HeLa Cells Humans Lysine Nucleic acids Nucleoli peptide nucleic acid Peptide nucleic acids Peptide Nucleic Acids - metabolism Peptides Ribonucleic acid RNA Vesicles
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