Development and Validation of a High-Throughput Screen for Inhibitors of SARS CoV and Its Application in Screening of a 100,000-Compound Library

The authors have developed a high-throughput screen (HTS) that allows for the identification of potential inhibitors of the severe acute respiratory syndrome coronavirus (SARS CoV) from large compound libraries. The luminescent-based assay measures the inhibition of SARS CoV–induced cytopathic effec...

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Veröffentlicht in:	Journal of biomolecular screening 2007-02, Vol.12 (1), p.33-40
Hauptverfasser:	Severson, William E., Shindo, Nice, Sosa, Mindy, Fletcher, Thomas, White, E. Lucile, Ananthan, Subramaniam, Jonsson, Colleen B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - analysis Antiviral Agents - chemistry Antiviral Agents - pharmacology Cell Count Chlorocebus aethiops Combinatorial Chemistry Techniques - methods Coronaviruses Diagnosis Dimethyl Sulfoxide Drug Evaluation, Preclinical Endpoint Determination Inhibitory Concentration 50 Luminescence Medical screening Reproducibility of Results SARS coronavirus SARS Virus - drug effects Severe acute respiratory syndrome Vero Cells
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