RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challenge

Multiple SARS-CoV-2 variants are identified with higher rates of transmissibility or greater disease severity. Particularly, recent emergence of Omicron variant with rapid human-to-human transmission posts new challenges to the current prevention strategies. In this study, following vaccination with...

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Veröffentlicht in:	Translational research : the journal of laboratory and clinical medicine 2022-10, Vol.248, p.11-21
Hauptverfasser:	Shi, Juan, Zheng, Jian, Zhang, Xiujuan, Tai, Wanbo, Odle, Abby E., Perlman, Stanley, Du, Lanying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral Broadly Neutralizing Antibodies COVID-19 Humans Mice Mice, Inbred BALB C mRNA Vaccines Mutation Neutralization Tests RNA, Messenger SARS-CoV-2 Spike Glycoprotein, Coronavirus Vaccines, Synthetic Viral Vaccines
Online-Zugang:	Volltext
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