In vitro generation of novel pyrimethamine resistance mutations in the Toxoplasma gondii dihydrofolate reductase

Pyrimethamine is a potent inhibitor of dihydrofolate reductase and is widely used in the treatment of opportunistic infections caused by the protozoan parasite Toxoplasma gondii. In order to assess the potential role of dhfr sequence polymorphisms in drug treatment failures, we examined the dhfr-ts...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2001-04, Vol.45 (4), p.1271-1277
Hauptverfasser:	REYNOLDS, Mary G, OH, Jung, ROOS, David S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Animals, Genetically Modified Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antiprotozoal Agents - pharmacology Bacteriology Biological and medical sciences Cell Line DHFR gene Drug Resistance Folic Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Genes, Protozoan Genetics Mechanisms of Resistance Medical sciences Microbiology Mutagenesis Parasitic Sensitivity Tests Pharmacology. Drug treatments Point Mutation Pyrimethamine Pyrimethamine - pharmacology Saccharomyces cerevisiae - genetics Tetrahydrofolate Dehydrogenase - genetics Toxoplasma - drug effects Toxoplasma - enzymology Toxoplasma - genetics Toxoplasma gondii Transfection
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