Potent Inhibition of SARS-CoV‑2 nsp14 N7‑Methyltransferase by Sulfonamide-Based Bisubstrate Analogues
Enzymes involved in RNA capping of SARS-CoV-2 are essential for the stability of viral RNA, translation of mRNAs, and virus evasion from innate immunity, making them attractive targets for antiviral agents. In this work, we focused on the design and synthesis of nucleoside-derived inhibitors against...
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Veröffentlicht in: | Journal of medicinal chemistry 2022-04, Vol.65 (8), p.6231-6249 |
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Hauptverfasser: | , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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