The landscape of molecular mechanism for aldosterone production in aldosterone-producing adenoma

Primary aldosteronism is the most common form of secondary hypertension with a prevalence of 5–10% in hypertensive patients. Aldosterone-producing adenoma (APA) is a subtype of primary aldosteronism, and somatic mutations in KCNJ5, ATP1A1, ATP2B3, CACNA1D, CLCN2, or CTNNB1 were identified and recogn...

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