Structural origin of cooperativity in human hemoglobin: a view from different roles of α and β subunits in the α2β2 tetramer

This mini-review, mainly based on our resonance Raman studies on the structural origin of cooperative O 2 binding in human adult hemoglobin (HbA), aims to answering why HbA is a tetramer consisting of two α and two β subunits. Here, we focus on the Fe-His bond, the sole coordination bond connecting...

Ausführliche Beschreibung