The Challenges of Predicting Drug-Induced QTc Prolongation in Humans

Abstract The content of this article derives from a Health and Environmental Sciences Institute (HESI) consortium with a focus to improve cardiac safety during drug development. A detailed literature review was conducted to evaluate the concordance between nonclinical repolarization assays and the c...

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Veröffentlicht in:	Toxicological sciences 2022-04, Vol.187 (1), p.3-24
Hauptverfasser:	Valentin, Jean-Pierre, Hoffmann, Peter, Ortemann-Renon, Catherine, Koerner, John, Pierson, Jennifer, Gintant, Gary, Willard, James, Garnett, Christine, Skinner, Matthew, Vargas, Hugo M, Wisialowski, Todd, Pugsley, Michael K
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Electrocardiography Heart Humans In-Depth Review Long QT Syndrome - chemically induced Retrospective Studies Torsades de Pointes - chemically induced
Online-Zugang:	Volltext
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