Role of mTOR through Autophagy in Esophageal Cancer Stemness

Esophageal cancer (EC) is a highly aggressive disease with a poor prognosis. Therapy resistance and early recurrences are major obstacles in reaching a better outcome. Esophageal cancer stem-like cells (CSCs) seem tightly related with chemoradiation resistance, initiating new tumors and metastases....

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Veröffentlicht in:	Cancers 2022-04, Vol.14 (7), p.1806
Hauptverfasser:	Du, Liang, Wang, Da, Nagle, Peter W, Groen, Andries A H, Zhang, Hao, Muijs, Christina T, Plukker, John Th M, Coppes, Robert P
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Cancer Cancer therapies CD44 antigen Cell culture Esophageal cancer Esophagus Homeostasis Hydroxychloroquine Hypoxia Kinases Metastases Metastasis Nutrition Organoids Oxygen Phosphorylation Population Prognosis Protein expression Proteins Radiation Rapamycin Spheres Therapeutic applications Therapeutic targets TOR protein Tumors
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