External Validation of a Nomogram Developed for Predicting Overall Survival in Gastric Cancer Patients with Insufficient Number of Examined Lymph Nodes

External Validation of a Nomogram Developed for Predicting Overall Survival in Gastric Cancer Patients with Insufficient Number of Examined Lymph Nodes

Nomograms and scoring systems in gastric cancers have been mainly developed based on adequate lymph node (lN) dissections. This study aimed to perform external validation of a nomogram developed for predicting overall survival (OS) in gastric cancer patients with insufficient number of examined LNs...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Şişli Etfal Hastanesi tıp bülteni 2022-01, Vol.56 (1), p.137-144
Hauptverfasser: Kubat, Mehmet, Yazicioglu, Mustafa Omer, Bozkirli, Bahadir Osman, Gundogdu, Riza Haldun
Format: Artikel
Sprache:eng
Schlagworte:
Original Research
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 144
container_issue 1
container_start_page 137
container_title Şişli Etfal Hastanesi tıp bülteni
container_volume 56
creator Kubat, Mehmet
Yazicioglu, Mustafa Omer
Bozkirli, Bahadir Osman
Gundogdu, Riza Haldun
description Nomograms and scoring systems in gastric cancers have been mainly developed based on adequate lymph node (lN) dissections. This study aimed to perform external validation of a nomogram developed for predicting overall survival (OS) in gastric cancer patients with insufficient number of examined LNs (eLNs) and to evaluate its usability as compared with the 8 American Joint Committee on Cancer (AJCC)'s Tumor-Node-Metastasis staging system. Medical records of 262 patients undergoing complete surgical resection for gastric cancers and having pathologically confirmed diagnosis were retrospectively reviewed. The study included 104 (39.7%) patients (82 males, median age, 60.3 years) with insufficient number of eLNs (
doi_str_mv 10.14744/SEMB.2021.47587
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9040297</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2661084719</sourcerecordid><originalsourceid>FETCH-LOGICAL-c279t-9fc83bc85dbe63c6064c1b7f84604cf817f4c44ad8a93030815ec8a259993f03</originalsourceid><addsrcrecordid>eNpVUU1v1DAQtRCIVkvvnJCPXLL1V2L7ggTLUiotLVIrrpbj2LtGib3YSWh_CX-33m2pwBePZt68NzMPgLcYLTHjjJ3frL99WhJE8JLxWvAX4BRTJKoaE_ryGJOKl_gEnOX8E5XXYMKZeA1OaF3jWnJ6Cv6s70abgu7hD937To8-Bhgd1PAqDnGb9AA_29n2cW876GKC35PtvBl92MLr2Sbd9_BmSrOfC4UP8ELnMXkDVzoYW9CF0IYxw99-3MHLkCfnvDmk4NU0tAVRtNZ3evCh8G_uh_2uCHc2vwGvnO6zPXv6F-D2y_p29bXaXF9crj5uKkO4HCvpjKCtEXXX2oaaBjXM4JY7wRrEjBOYO2YY053QkqJyHVxbIzSppZTUIboAHx5p91M72M6UwcpKap_8oNO9itqr_yvB79Q2zkoihki54AK8fyJI8ddk86gGn43tex1snLIiTYORYBzLAkWPUJNizsm6ZxmM1NFRdXBUHRxVR0dLy7t_x3tu-OsffQCbqZ9M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2661084719</pqid></control><display><type>article</type><title>External Validation of a Nomogram Developed for Predicting Overall Survival in Gastric Cancer Patients with Insufficient Number of Examined Lymph Nodes</title><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Kubat, Mehmet ; Yazicioglu, Mustafa Omer ; Bozkirli, Bahadir Osman ; Gundogdu, Riza Haldun</creator><creatorcontrib>Kubat, Mehmet ; Yazicioglu, Mustafa Omer ; Bozkirli, Bahadir Osman ; Gundogdu, Riza Haldun</creatorcontrib><description>Nomograms and scoring systems in gastric cancers have been mainly developed based on adequate lymph node (lN) dissections. This study aimed to perform external validation of a nomogram developed for predicting overall survival (OS) in gastric cancer patients with insufficient number of examined LNs (eLNs) and to evaluate its usability as compared with the 8 American Joint Committee on Cancer (AJCC)'s Tumor-Node-Metastasis staging system. Medical records of 262 patients undergoing complete surgical resection for gastric cancers and having pathologically confirmed diagnosis were retrospectively reviewed. The study included 104 (39.7%) patients (82 males, median age, 60.3 years) with insufficient number of eLNs (&lt;16). The 5-year OS rate was calculated using the nomogram and according to the AJCC system. The median follow-up period was 37.4 months (range: 0.9-122.9). Of the patients, 69 (66.3%) died and 35 (33.7%) achieved 5-year survival within the follow-up period. The nomogram and the AJCC system predicted OS were significantly lower in patients who died than in those who achieved 5-year survival (p&lt;0.001 for both). According to the receiver operative characteristics-curve, the area under the curve for the nomogram (0.801; 95% CI, 0.715-0.887; p&lt;0.001) was larger than that for the AJCC system (0.754; 95% CI, 0.659-0.849; p&lt;0.001). The nomogram developed for gastric cancer patients with insufficient number of eLNs (&lt;16) was effective in predicting 5-year OS in our cohort and was superior to the AJCC system.</description><identifier>ISSN: 1302-7123</identifier><identifier>EISSN: 1308-5123</identifier><identifier>DOI: 10.14744/SEMB.2021.47587</identifier><identifier>PMID: 35515973</identifier><language>eng</language><publisher>Turkey: Med Bull Sisli Etfal Hosp</publisher><subject>Original Research</subject><ispartof>Şişli Etfal Hastanesi tıp bülteni, 2022-01, Vol.56 (1), p.137-144</ispartof><rights>Copyright 2022 by The Medical Bulletin of Sisli Etfal Hospital - Available online at www.sislietfaltip.org.</rights><rights>Copyright 2022 by The Medical Bulletin of Sisli Etfal Hospital - Available online at 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-3422-194X ; 0000-0002-8507-7124 ; 0000-0001-6150-0226 ; 0000-0002-7021-4827</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040297/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040297/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35515973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kubat, Mehmet</creatorcontrib><creatorcontrib>Yazicioglu, Mustafa Omer</creatorcontrib><creatorcontrib>Bozkirli, Bahadir Osman</creatorcontrib><creatorcontrib>Gundogdu, Riza Haldun</creatorcontrib><title>External Validation of a Nomogram Developed for Predicting Overall Survival in Gastric Cancer Patients with Insufficient Number of Examined Lymph Nodes</title><title>Şişli Etfal Hastanesi tıp bülteni</title><addtitle>Sisli Etfal Hastan Tip Bul</addtitle><description>Nomograms and scoring systems in gastric cancers have been mainly developed based on adequate lymph node (lN) dissections. This study aimed to perform external validation of a nomogram developed for predicting overall survival (OS) in gastric cancer patients with insufficient number of examined LNs (eLNs) and to evaluate its usability as compared with the 8 American Joint Committee on Cancer (AJCC)'s Tumor-Node-Metastasis staging system. Medical records of 262 patients undergoing complete surgical resection for gastric cancers and having pathologically confirmed diagnosis were retrospectively reviewed. The study included 104 (39.7%) patients (82 males, median age, 60.3 years) with insufficient number of eLNs (&lt;16). The 5-year OS rate was calculated using the nomogram and according to the AJCC system. The median follow-up period was 37.4 months (range: 0.9-122.9). Of the patients, 69 (66.3%) died and 35 (33.7%) achieved 5-year survival within the follow-up period. The nomogram and the AJCC system predicted OS were significantly lower in patients who died than in those who achieved 5-year survival (p&lt;0.001 for both). According to the receiver operative characteristics-curve, the area under the curve for the nomogram (0.801; 95% CI, 0.715-0.887; p&lt;0.001) was larger than that for the AJCC system (0.754; 95% CI, 0.659-0.849; p&lt;0.001). The nomogram developed for gastric cancer patients with insufficient number of eLNs (&lt;16) was effective in predicting 5-year OS in our cohort and was superior to the AJCC system.</description><subject>Original Research</subject><issn>1302-7123</issn><issn>1308-5123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpVUU1v1DAQtRCIVkvvnJCPXLL1V2L7ggTLUiotLVIrrpbj2LtGib3YSWh_CX-33m2pwBePZt68NzMPgLcYLTHjjJ3frL99WhJE8JLxWvAX4BRTJKoaE_ryGJOKl_gEnOX8E5XXYMKZeA1OaF3jWnJ6Cv6s70abgu7hD937To8-Bhgd1PAqDnGb9AA_29n2cW876GKC35PtvBl92MLr2Sbd9_BmSrOfC4UP8ELnMXkDVzoYW9CF0IYxw99-3MHLkCfnvDmk4NU0tAVRtNZ3evCh8G_uh_2uCHc2vwGvnO6zPXv6F-D2y_p29bXaXF9crj5uKkO4HCvpjKCtEXXX2oaaBjXM4JY7wRrEjBOYO2YY053QkqJyHVxbIzSppZTUIboAHx5p91M72M6UwcpKap_8oNO9itqr_yvB79Q2zkoihki54AK8fyJI8ddk86gGn43tex1snLIiTYORYBzLAkWPUJNizsm6ZxmM1NFRdXBUHRxVR0dLy7t_x3tu-OsffQCbqZ9M</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Kubat, Mehmet</creator><creator>Yazicioglu, Mustafa Omer</creator><creator>Bozkirli, Bahadir Osman</creator><creator>Gundogdu, Riza Haldun</creator><general>Med Bull Sisli Etfal Hosp</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3422-194X</orcidid><orcidid>https://orcid.org/0000-0002-8507-7124</orcidid><orcidid>https://orcid.org/0000-0001-6150-0226</orcidid><orcidid>https://orcid.org/0000-0002-7021-4827</orcidid></search><sort><creationdate>20220101</creationdate><title>External Validation of a Nomogram Developed for Predicting Overall Survival in Gastric Cancer Patients with Insufficient Number of Examined Lymph Nodes</title><author>Kubat, Mehmet ; Yazicioglu, Mustafa Omer ; Bozkirli, Bahadir Osman ; Gundogdu, Riza Haldun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c279t-9fc83bc85dbe63c6064c1b7f84604cf817f4c44ad8a93030815ec8a259993f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Original Research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kubat, Mehmet</creatorcontrib><creatorcontrib>Yazicioglu, Mustafa Omer</creatorcontrib><creatorcontrib>Bozkirli, Bahadir Osman</creatorcontrib><creatorcontrib>Gundogdu, Riza Haldun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Şişli Etfal Hastanesi tıp bülteni</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kubat, Mehmet</au><au>Yazicioglu, Mustafa Omer</au><au>Bozkirli, Bahadir Osman</au><au>Gundogdu, Riza Haldun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>External Validation of a Nomogram Developed for Predicting Overall Survival in Gastric Cancer Patients with Insufficient Number of Examined Lymph Nodes</atitle><jtitle>Şişli Etfal Hastanesi tıp bülteni</jtitle><addtitle>Sisli Etfal Hastan Tip Bul</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>56</volume><issue>1</issue><spage>137</spage><epage>144</epage><pages>137-144</pages><issn>1302-7123</issn><eissn>1308-5123</eissn><abstract>Nomograms and scoring systems in gastric cancers have been mainly developed based on adequate lymph node (lN) dissections. This study aimed to perform external validation of a nomogram developed for predicting overall survival (OS) in gastric cancer patients with insufficient number of examined LNs (eLNs) and to evaluate its usability as compared with the 8 American Joint Committee on Cancer (AJCC)'s Tumor-Node-Metastasis staging system. Medical records of 262 patients undergoing complete surgical resection for gastric cancers and having pathologically confirmed diagnosis were retrospectively reviewed. The study included 104 (39.7%) patients (82 males, median age, 60.3 years) with insufficient number of eLNs (&lt;16). The 5-year OS rate was calculated using the nomogram and according to the AJCC system. The median follow-up period was 37.4 months (range: 0.9-122.9). Of the patients, 69 (66.3%) died and 35 (33.7%) achieved 5-year survival within the follow-up period. The nomogram and the AJCC system predicted OS were significantly lower in patients who died than in those who achieved 5-year survival (p&lt;0.001 for both). According to the receiver operative characteristics-curve, the area under the curve for the nomogram (0.801; 95% CI, 0.715-0.887; p&lt;0.001) was larger than that for the AJCC system (0.754; 95% CI, 0.659-0.849; p&lt;0.001). The nomogram developed for gastric cancer patients with insufficient number of eLNs (&lt;16) was effective in predicting 5-year OS in our cohort and was superior to the AJCC system.</abstract><cop>Turkey</cop><pub>Med Bull Sisli Etfal Hosp</pub><pmid>35515973</pmid><doi>10.14744/SEMB.2021.47587</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3422-194X</orcidid><orcidid>https://orcid.org/0000-0002-8507-7124</orcidid><orcidid>https://orcid.org/0000-0001-6150-0226</orcidid><orcidid>https://orcid.org/0000-0002-7021-4827</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1302-7123
ispartof Şişli Etfal Hastanesi tıp bülteni, 2022-01, Vol.56 (1), p.137-144
issn 1302-7123
1308-5123
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9040297
source PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Original Research
title External Validation of a Nomogram Developed for Predicting Overall Survival in Gastric Cancer Patients with Insufficient Number of Examined Lymph Nodes
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T12%3A56%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=External%20Validation%20of%20a%20Nomogram%20Developed%20for%20Predicting%20Overall%20Survival%20in%20Gastric%20Cancer%20Patients%20with%20Insufficient%20Number%20of%20Examined%20Lymph%20Nodes&rft.jtitle=%C5%9Ei%C5%9Fli%20Etfal%20Hastanesi%20t%C4%B1p%20b%C3%BClteni&rft.au=Kubat,%20Mehmet&rft.date=2022-01-01&rft.volume=56&rft.issue=1&rft.spage=137&rft.epage=144&rft.pages=137-144&rft.issn=1302-7123&rft.eissn=1308-5123&rft_id=info:doi/10.14744/SEMB.2021.47587&rft_dat=%3Cproquest_pubme%3E2661084719%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2661084719&rft_id=info:pmid/35515973&rfr_iscdi=true