Improved outcomes and staging in non-small-cell lung cancer guided by a molecular assay

There remains a critical need for improved staging of non-small-cell lung cancer, as recurrence and mortality due to undetectable metastases at the time of surgery remain high even after complete resection of tumors currently categorized as ‘early stage.’ A 14-gene quantitative PCR-based expression...

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Veröffentlicht in:	Future oncology (London, England) England), 2021-12, Vol.17 (34), p.4785-4795
Hauptverfasser:	Gupta, Alexander R, Woodard, Gavitt A, Jablons, David M, Mann, Michael J, Kratz, Johannes R
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvant therapy Biomarkers, Tumor - genetics Carcinogenesis - genetics Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - therapy Chemotherapy, Adjuvant - statistics & numerical data Clinical Decision-Making Datasets as Topic Disease-Free Survival Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - therapy molecular assay Molecular Diagnostic Techniques - methods Molecular Diagnostic Techniques - statistics & numerical data molecular prognostic classifier Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - prevention & control Neoplasm Staging - methods non-small-cell lung cancer Pneumonectomy - statistics & numerical data predictive Prospective Studies Real-Time Polymerase Chain Reaction Review Risk Assessment - methods risk stratification tumor genetic profile
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