NF-κB Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II–Hypertensive Mice

Worsened stroke outcomes with hypertension comorbidity are insensitive to blood pressure-lowering therapies. In an experimental stroke model with comorbid hypertension, we investigated causal roles of ang II (angiotensin II)-mediated stimulation of the brain WNK (with no lysine [K] kinases)-SPAK (ST...

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Veröffentlicht in:	Stroke (1970) 2022-05, Vol.53 (5), p.1720-1734
Hauptverfasser:	Bhuiyan, Mohammad Iqbal H., Young, Cullen B., Jahan, Israt, Hasan, Md Nabiul, Fischer, Sydney, Meor Azlan, Nur Farah, Liu, Mingjun, Chattopadhyay, Ansuman, Huang, Huachen, Kahle, Kristopher T., Zhang, Jinwei, Poloyac, Samuel M., Molyneaux, Bradley J., Straub, Adam C., Deng, Xianming, Gomez, Delphine, Sun, Dandan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Hypertension Ischemic Stroke Male Mice Mice, Inbred C57BL NF-kappa B Protein Serine-Threonine Kinases Solute Carrier Family 12, Member 2 - genetics Solute Carrier Family 12, Member 2 - metabolism Stroke - pathology
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