Neuroinflammation, Stem Cells, and Stroke
Stroke remains a significant unmet clinical need with few treatment options that have a very narrow therapeutic window, thereby causing massive mortality and morbidity in the United States and around the world. Accordingly, finding safe and effective novel treatments with a wider therapeutic window...
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| Veröffentlicht in: | Stroke (1970) 2022-05, Vol.53 (5), p.1460-1472 |
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| container_issue | 5 |
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| container_title | Stroke (1970) |
| container_volume | 53 |
| creator | Anthony, Stefan Cabantan, Dorothy Monsour, Molly Borlongan, Cesario V. |
| description | Stroke remains a significant unmet clinical need with few treatment options that have a very narrow therapeutic window, thereby causing massive mortality and morbidity in the United States and around the world. Accordingly, finding safe and effective novel treatments with a wider therapeutic window stands as an urgent need in stroke. The progressive inflammation that occurs centrally and peripherally after stroke serves as a unique therapeutic target to retard and even halt the secondary cell death. Stem cell therapy represents a potent approach that can diminish inflammation in both the stroke brain and periphery (eg, spleen), advancing a paradigm shift from a traditionally brain-focused therapy to treating stroke as a neurological disorder with a significant peripheral pathology. The purpose of this review article is to highlight the inflammation-mediated secondary cell death that plagues both brain and spleen in stroke and to evaluate the therapeutic potential of stem cell therapy in dampening these inflammatory responses. |
| doi_str_mv | 10.1161/STROKEAHA.121.036948 |
| format | Article |
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The purpose of this review article is to highlight the inflammation-mediated secondary cell death that plagues both brain and spleen in stroke and to evaluate the therapeutic potential of stem cell therapy in dampening these inflammatory responses.</description><subject>Humans</subject><subject>Inflammation - etiology</subject><subject>Inflammation - therapy</subject><subject>Neuroinflammatory Diseases</subject><subject>Stem Cell Transplantation</subject><subject>Stroke - complications</subject><subject>United States</subject><issn>0039-2499</issn><issn>1524-4628</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUlPwzAQhS0EgrL8A4R6BKkp4z25IFUVm0BUYjlbjjOlgSQGOwHx7wkqFDhZ9rz3ZuYzIfsUxpQqenx3fzu7Op1cTMaU0TFwlYl0jQyoZCIRiqXrZADAs4SJLNsi2zE-AQDjqdwkW1zyFEDCgBzdYBd82cwrW9e2LX0zGt61WA-nWFVxNLRN0d-Df8ZdsjG3VcS973OHPJyd3k8vkuvZ-eV0cp04IblMlMKcYZHTTNGcK6m0s4XTmqNiQnBFmdaSs7wQyFPqpE6pVXPubGadopDzHXKyzH3p8hoLh00bbGVeQlnb8GG8Lc3_SlMuzKN_MxnwVKWyDzj8Dgj-tcPYmrqMrl_HNui7aJgSmlEqBPRSsZS64GMMOF-1oWC-KJsVZdNTNkvKve3g74gr0w_W39x3X7UY4nPVvWMwC7RVuzD9P4BWGhIGjPVygOTrSfJPaNaHjg</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Anthony, Stefan</creator><creator>Cabantan, Dorothy</creator><creator>Monsour, Molly</creator><creator>Borlongan, Cesario V.</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6346-3876</orcidid><orcidid>https://orcid.org/0000-0003-1369-9626</orcidid><orcidid>https://orcid.org/0000-0001-9801-7465</orcidid><orcidid>https://orcid.org/0000-0002-2966-9782</orcidid></search><sort><creationdate>20220501</creationdate><title>Neuroinflammation, Stem Cells, and Stroke</title><author>Anthony, Stefan ; Cabantan, Dorothy ; Monsour, Molly ; Borlongan, Cesario V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4535-66eb2edb1961b36567cadc773e6244361277532bd4e381c5781a6f3ca9ac610b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Humans</topic><topic>Inflammation - etiology</topic><topic>Inflammation - therapy</topic><topic>Neuroinflammatory Diseases</topic><topic>Stem Cell Transplantation</topic><topic>Stroke - complications</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anthony, Stefan</creatorcontrib><creatorcontrib>Cabantan, Dorothy</creatorcontrib><creatorcontrib>Monsour, Molly</creatorcontrib><creatorcontrib>Borlongan, Cesario V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anthony, Stefan</au><au>Cabantan, Dorothy</au><au>Monsour, Molly</au><au>Borlongan, Cesario V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroinflammation, Stem Cells, and Stroke</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>53</volume><issue>5</issue><spage>1460</spage><epage>1472</epage><pages>1460-1472</pages><issn>0039-2499</issn><issn>1524-4628</issn><eissn>1524-4628</eissn><abstract>Stroke remains a significant unmet clinical need with few treatment options that have a very narrow therapeutic window, thereby causing massive mortality and morbidity in the United States and around the world. 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| fulltext | fulltext |
| identifier | ISSN: 0039-2499 |
| ispartof | Stroke (1970), 2022-05, Vol.53 (5), p.1460-1472 |
| issn | 0039-2499 1524-4628 1524-4628 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9038685 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Humans Inflammation - etiology Inflammation - therapy Neuroinflammatory Diseases Stem Cell Transplantation Stroke - complications United States |
| title | Neuroinflammation, Stem Cells, and Stroke |
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