A novel tick protein supports integrity of gut peritrophic matrix impacting existence of gut microbiome and Lyme disease pathogens

The peritrophic matrix (PM) is an acellular membrane that covers the gut epithelium in arthropods and physically separates it from the lumen. The structure is thought to play an important role in tick biology. The PM is also known to impact the persistence of tick‐borne pathogens like Borrelia burgd...

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Veröffentlicht in:	Cellular microbiology 2021-02, Vol.23 (2), p.e13275-n/a
Hauptverfasser:	Yang, Xiuli, Koči, Juraj, Smith, Alexis A., Zhuang, Xuran, Sharma, Kavita, Dutta, Shraboni, Rana, Vipin S., Kitsou, Chrysoula, Yas, Ozlem B., Mongodin, Emmanuel F., Pal, Utpal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Arachnids Arthropod Proteins - metabolism Arthropods Borrelia burgdorferi - pathogenicity Borrelia burgdorferi - physiology Carrier Proteins - metabolism Chitin Chitin - metabolism Chitin deacetylase Constituents Dextran Dextrans DNA, Bacterial Engorgement Epithelium Female Fluorescence Gastrointestinal Microbiome Gene expression Gene Knockdown Techniques Homology Host-Pathogen Interactions infection Intestinal microflora Intestinal Mucosa - microbiology Ixodes - metabolism Ixodes - microbiology Lyme disease Lyme Disease - microbiology Membrane proteins Membranes Mice Mice, Inbred C3H microbial‐cell interaction Microbiomes Pathogens Peritrophic membrane Protein Binding Proteins RNA Interference RNA, Ribosomal, 16S RNA-mediated interference Structural integrity Ticks vaccines Vector-borne diseases
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