Silencing ATF3 Might Delay TBHP-Induced Intervertebral Disc Degeneration by Repressing NPC Ferroptosis, Apoptosis, and ECM Degradation

Intervertebral disc degeneration (IDD), being the predominant root cause of lower back pain, has led to an enormous socioeconomic burden in the world. Ferroptosis is an iron-dependent nonapoptotic and nonpyroptotic programmed cell death associated with an increase in reactive oxygen species (ROS), w...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2022, Vol.2022, p.4235126-17
Hauptverfasser:	Li, Yongjin, Pan, Dayu, Wang, Xuke, Huo, Zhenxin, Wu, Xiaojing, Li, Jianhua, Cao, Jiasong, Xu, Haiwei, Du, Lilong, Xu, Baoshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 3 - genetics Activating Transcription Factor 3 - metabolism Animals Apoptosis Apoptosis - genetics Bioinformatics Datasets Degenerative disc disease Experiments Ferroptosis Ferroptosis - genetics Gene expression Humans Intervertebral Disc Degeneration - pathology Metabolism MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Nucleus Pulposus - pathology Oxidative stress Physiology Proteins Rats Reactive oxygen species Reactive Oxygen Species - metabolism Software Transcription factors
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