GIRK3 deletion facilitates kappa opioid signaling in chondrocytes, delays vascularization and promotes bone lengthening in mice

Long bones are formed and repaired through the process of endochondral ossification. Activation of G protein-coupled receptor (GPCR) signaling pathways is crucial for skeletal development and long bone growth. G protein-gated inwardly-rectifying K+ (GIRK) channel genes are key functional components...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2022-06, Vol.159, p.116391-116391, Article 116391
Hauptverfasser:	Taylor, Earnest L., Weaver, Samantha R., Lorang, Ian M., Arnold, Katherine M., Bradley, Elizabeth W., Marron Fernandez de Velasco, Ezequiel, Wickman, Kevin, Westendorf, Jennifer J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - metabolism Animals Bone Lengthening Brain - metabolism Cartilage Chondrocytes - metabolism Development G protein G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism GPCR K+ channel Kappa opioid Mice
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!