A curious case of cyclin‐dependent kinases in neutrophils
Neutrophils are terminally differentiated, short‐lived white blood cells critical for innate immunity. Although cyclin‐dependent kinases (CDKs) are typically related to cell cycle progression, increasing evidence has shown that they regulate essential functions of neutrophils. This review highlights...
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| Veröffentlicht in: | Journal of leukocyte biology 2022-05, Vol.111 (5), p.1057-1068 |
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| creator | Syahirah, Ramizah Hsu, Alan Y. Deng, Qing |
| description | Neutrophils are terminally differentiated, short‐lived white blood cells critical for innate immunity. Although cyclin‐dependent kinases (CDKs) are typically related to cell cycle progression, increasing evidence has shown that they regulate essential functions of neutrophils. This review highlights the roles of CDKs and their partners, cyclins, in neutrophils, outside of cell cycle regulation. CDK1‐10 and several cyclins are expressed in neutrophils, albeit at different levels. Observed phenotypes associated with specific inhibition or genetic loss of CDK2 indicate its role in modulating neutrophil migration. CDK4 and 6 regulate neutrophil extracellular traps (NETs) formation, while CDK5 regulates neutrophil degranulation. CDK7 and 9 are critical in neutrophil apoptosis, contributing to inflammation resolution. In addition to the CDKs that regulate mature neutrophil functions, cyclins are essential in hematopoiesis and granulopoiesis. The pivotal roles of CDKs in neutrophils present an untapped potential in targeting CDKs for treating neutrophil‐dominant inflammatory diseases and understanding the regulation of the neutrophil life cycle.
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CDK regulation of neutrophil function as a potential target in neutrophil‐dominant inflammatory diseases. |
| doi_str_mv | 10.1002/JLB.2RU1021-573R |
| format | Article |
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Graphical
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Graphical
CDK regulation of neutrophil function as a potential target in neutrophil‐dominant inflammatory diseases.</description><subject>CDK2</subject><subject>Cell Cycle Checkpoints</subject><subject>Cyclins - genetics</subject><subject>Cyclins - metabolism</subject><subject>granulopoiesis</subject><subject>HL‐60 cells</subject><subject>innate immunity</subject><subject>neutrophil activation</subject><subject>Neutrophils - metabolism</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRtH7cPUmOXqKzH9lsEAQtflIQij0v282srqZJzTZKb_4Ef6O_xC2toidPAzPvvPPOQ8g-hSMKwI5vB-dHbDiiwGia5Xy4Rnq04CrlMufrpAe5iH0BsEW2Q3gCAM4kbJItnlGlZCF75OQssV3rmy4k1gRMGpfYua18_fn-UeIU6xLrWfLs6zgMia-TGrtZ20wffRV2yYYzVcC9Vd0ho8uL-_51Ori7uumfDVIrBIe0QOdyVY5BKFnKXBklhBuLrCyV5KVkwiru0ChJswIco4qBKzK0Y6sADSLfIadL32k3nmBpY6LWVHra-olp57oxXv-d1P5RPzSvugCeQZZFg8OVQdu8dBhmeuKDxaoyNcbPNZOcSpoLwaIUllLbNiG06H7OUNAL5joy1yvmesE8rhz8jvez8A05CuRS8OYrnP9ruGhQCjH8Fwhfj0Q</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Syahirah, Ramizah</creator><creator>Hsu, Alan Y.</creator><creator>Deng, Qing</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202205</creationdate><title>A curious case of cyclin‐dependent kinases in neutrophils</title><author>Syahirah, Ramizah ; Hsu, Alan Y. ; Deng, Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4430-9eff78db0486d678a844fb45dd863d624c83fea861590f21820f95ecbc80eaee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>CDK2</topic><topic>Cell Cycle Checkpoints</topic><topic>Cyclins - genetics</topic><topic>Cyclins - metabolism</topic><topic>granulopoiesis</topic><topic>HL‐60 cells</topic><topic>innate immunity</topic><topic>neutrophil activation</topic><topic>Neutrophils - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Syahirah, Ramizah</creatorcontrib><creatorcontrib>Hsu, Alan Y.</creatorcontrib><creatorcontrib>Deng, Qing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Syahirah, Ramizah</au><au>Hsu, Alan Y.</au><au>Deng, Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A curious case of cyclin‐dependent kinases in neutrophils</atitle><jtitle>Journal of leukocyte biology</jtitle><addtitle>J Leukoc Biol</addtitle><date>2022-05</date><risdate>2022</risdate><volume>111</volume><issue>5</issue><spage>1057</spage><epage>1068</epage><pages>1057-1068</pages><issn>0741-5400</issn><eissn>1938-3673</eissn><abstract>Neutrophils are terminally differentiated, short‐lived white blood cells critical for innate immunity. Although cyclin‐dependent kinases (CDKs) are typically related to cell cycle progression, increasing evidence has shown that they regulate essential functions of neutrophils. This review highlights the roles of CDKs and their partners, cyclins, in neutrophils, outside of cell cycle regulation. CDK1‐10 and several cyclins are expressed in neutrophils, albeit at different levels. Observed phenotypes associated with specific inhibition or genetic loss of CDK2 indicate its role in modulating neutrophil migration. CDK4 and 6 regulate neutrophil extracellular traps (NETs) formation, while CDK5 regulates neutrophil degranulation. CDK7 and 9 are critical in neutrophil apoptosis, contributing to inflammation resolution. In addition to the CDKs that regulate mature neutrophil functions, cyclins are essential in hematopoiesis and granulopoiesis. The pivotal roles of CDKs in neutrophils present an untapped potential in targeting CDKs for treating neutrophil‐dominant inflammatory diseases and understanding the regulation of the neutrophil life cycle.
Graphical
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| ispartof | Journal of leukocyte biology, 2022-05, Vol.111 (5), p.1057-1068 |
| issn | 0741-5400 1938-3673 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | CDK2 Cell Cycle Checkpoints Cyclins - genetics Cyclins - metabolism granulopoiesis HL‐60 cells innate immunity neutrophil activation Neutrophils - metabolism |
| title | A curious case of cyclin‐dependent kinases in neutrophils |
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