Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice

Several cellular pathways contribute to neurodegenerative tauopathy-related disorders. Microglial activation, a major component of neuroinflammation, is an early pathologic hallmark that correlates with cognitive decline, while the unfolded protein response (UPR) contributes to synaptic pathology. S...

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Veröffentlicht in:	The Journal of neuroscience 2022-04, Vol.42 (16), p.3494-3509
Hauptverfasser:	de Oliveira, Paula, Cella, Claire, Locker, Nicolas, Ravindran, Kiran K G, Mendis, Agampodi, Wafford, Keith, Gilmour, Gary, Dijk, Derk-Jan, Winsky-Sommerer, Raphaelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Animals Antidepressants Chemical compounds Cognitive ability Correlation Dementia Dementia disorders Disease Models, Animal Disease Progression Humans Inflammasomes Inflammation Kinases Male MAP kinase Memory Memory Disorders - genetics Mice Mice, Transgenic Neurodegenerative diseases NLR Family, Pyrin Domain-Containing 3 Protein Oscillations Pharmacology Phenotypes Protein folding Protein kinase Proteins REM sleep Sleep Sleep - physiology Sleep Wake Disorders Tau protein tau Proteins - metabolism Tauopathies - metabolism Theta rhythms Trazodone - pharmacology Trazodone - therapeutic use
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