Novel Evidence That Alternative Pathway of Complement Cascade Activation is Required for Optimal Homing and Engraftment of Hematopoietic Stem/progenitor Cells
We reported in the past that activation of the third (C3) and fifth element (C5) of complement cascade (ComC) is required for a proper homing and engraftment of transplanted hematopoietic stem/progenitor cells (HSPCs). Since myeloablative conditioning for transplantation triggers in recipient bone m...
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| Veröffentlicht in: | Stem cell reviews and reports 2022-04, Vol.18 (4), p.1355-1365 |
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| creator | Adamiak, Mateusz Ciechanowicz, Andrzej Chumak, Vira Bujko, Kamila Ratajczak, Janina Brzezniakiewicz-Janus, Katarzyna Kucia, Magdalena Ratajczak, Mariusz Z. |
| description | We reported in the past that activation of the third (C3) and fifth element (C5) of complement cascade (ComC) is required for a proper homing and engraftment of transplanted hematopoietic stem/progenitor cells (HSPCs). Since myeloablative conditioning for transplantation triggers in recipient bone marrow (BM) state of sterile inflammation, we have become interested in the role of complement in this process and the potential involvement of alternative pathway of ComC activation. We noticed that factor B deficient mice (FB-KO) that do not activate properly alternative pathway, engraft poorly with BM cells from normal wild type (WT) mice. We observed defects both in homing and engraftment of transplanted HSPCs. To shed more light on these phenomena, we found that myeloablative lethal irradiation conditioning for transplantation activates purinergic signaling, ComC, and Nlrp3 inflammasome in WT mice, which is significantly impaired in FB-KO animals. Our proteomics analysis revealed that conditioned for transplantation lethally irradiated FB-KO compared to normal control animals have lower expression of several proteins involved in positive regulation of cell migration, trans-endothelial migration, immune system, cellular signaling protein, and metabolic pathways. Overall, our recent study further supports the role of innate immunity in homing and engraftment of HSPCs.
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| doi_str_mv | 10.1007/s12015-021-10318-4 |
| format | Article |
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Graphical Abstract</description><identifier>ISSN: 2629-3269</identifier><identifier>EISSN: 2629-3277</identifier><identifier>DOI: 10.1007/s12015-021-10318-4</identifier><identifier>PMID: 35013937</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alternative pathway ; Animals ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Bone marrow ; Bone Marrow - metabolism ; Bone marrow transplantation ; Cell Biology ; Cell migration ; Complement Activation ; Complement component C3 ; Complement component C5 ; Cytokines ; Granulocytes ; Hematology ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells ; Homing behavior ; Immune system ; Inflammasomes ; Inflammasomes - metabolism ; Inflammation ; Innate immunity ; Laboratories ; Life Sciences ; Metabolic pathways ; Mice ; Progenitor cells ; Proteins ; Proteomics ; Radiation ; Regenerative Medicine/Tissue Engineering ; Signal transduction ; Stem Cells ; Transplants & implants</subject><ispartof>Stem cell reviews and reports, 2022-04, Vol.18 (4), p.1355-1365</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-5100318a6f1876a1340058e93c5c38a2b0c2986075735520e229937e18e0ee673</citedby><cites>FETCH-LOGICAL-c474t-5100318a6f1876a1340058e93c5c38a2b0c2986075735520e229937e18e0ee673</cites><orcidid>0000-0002-9110-5048 ; 0000-0002-0071-0198</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12015-021-10318-4$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12015-021-10318-4$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35013937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adamiak, Mateusz</creatorcontrib><creatorcontrib>Ciechanowicz, Andrzej</creatorcontrib><creatorcontrib>Chumak, Vira</creatorcontrib><creatorcontrib>Bujko, Kamila</creatorcontrib><creatorcontrib>Ratajczak, Janina</creatorcontrib><creatorcontrib>Brzezniakiewicz-Janus, Katarzyna</creatorcontrib><creatorcontrib>Kucia, Magdalena</creatorcontrib><creatorcontrib>Ratajczak, Mariusz Z.</creatorcontrib><title>Novel Evidence That Alternative Pathway of Complement Cascade Activation is Required for Optimal Homing and Engraftment of Hematopoietic Stem/progenitor Cells</title><title>Stem cell reviews and reports</title><addtitle>Stem Cell Rev and Rep</addtitle><addtitle>Stem Cell Rev Rep</addtitle><description>We reported in the past that activation of the third (C3) and fifth element (C5) of complement cascade (ComC) is required for a proper homing and engraftment of transplanted hematopoietic stem/progenitor cells (HSPCs). Since myeloablative conditioning for transplantation triggers in recipient bone marrow (BM) state of sterile inflammation, we have become interested in the role of complement in this process and the potential involvement of alternative pathway of ComC activation. We noticed that factor B deficient mice (FB-KO) that do not activate properly alternative pathway, engraft poorly with BM cells from normal wild type (WT) mice. We observed defects both in homing and engraftment of transplanted HSPCs. To shed more light on these phenomena, we found that myeloablative lethal irradiation conditioning for transplantation activates purinergic signaling, ComC, and Nlrp3 inflammasome in WT mice, which is significantly impaired in FB-KO animals. Our proteomics analysis revealed that conditioned for transplantation lethally irradiated FB-KO compared to normal control animals have lower expression of several proteins involved in positive regulation of cell migration, trans-endothelial migration, immune system, cellular signaling protein, and metabolic pathways. Overall, our recent study further supports the role of innate immunity in homing and engraftment of HSPCs.
Graphical Abstract</description><subject>Alternative pathway</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Bone marrow</subject><subject>Bone Marrow - metabolism</subject><subject>Bone marrow transplantation</subject><subject>Cell Biology</subject><subject>Cell migration</subject><subject>Complement Activation</subject><subject>Complement component C3</subject><subject>Complement component C5</subject><subject>Cytokines</subject><subject>Granulocytes</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Hematopoietic Stem Cells</subject><subject>Homing behavior</subject><subject>Immune system</subject><subject>Inflammasomes</subject><subject>Inflammasomes - metabolism</subject><subject>Inflammation</subject><subject>Innate immunity</subject><subject>Laboratories</subject><subject>Life Sciences</subject><subject>Metabolic pathways</subject><subject>Mice</subject><subject>Progenitor cells</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>Radiation</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Signal transduction</subject><subject>Stem Cells</subject><subject>Transplants & implants</subject><issn>2629-3269</issn><issn>2629-3277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9ks1u1DAUhS0EotXQF2CBLLFhE-qfOE42SKNoYJAqiqCsLde5ybhK7NR2BvVleFbcThl-Fqxsyd89vufeg9BLSt5SQuR5pIxQURBGC0o4rYvyCTplFWsKzqR8erxXzQk6i_GGEMI4KXPNc3TCBaG84fIU_fjk9zDizd524Azgq51OeD0mCE4nuwf8Wafdd32HfY9bP80jTOASbnU0ugO8NhnKoHfYRvwFbhcboMO9D_hyTnbSI976yboBa9fhjRuC7tODQtbbwqSTn72FZA3-mmA6n4MfwNmU61sYx_gCPev1GOHs8Vyhb-83V-22uLj88LFdXxSmlGUqRB5JnoGuelrLSlNeEiJqaLgRhteaXRPDmroiUkguBCPAWJPtA62BAFSSr9C7g-68XE_Qmdxh0KOaQ7YQ7pTXVv394uxODX6vGsK5zAtYoTePAsHfLhCTmmw02YJ24JeoWEXrhohGsIy-_ge98Use93hPCV7SMnvJFDtQJvgYA_THZihR9wlQhwSonAD1kABV5qJXf9o4lvzadwb4AYj5yQ0Qfv_9H9mf1-u8yA</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Adamiak, Mateusz</creator><creator>Ciechanowicz, Andrzej</creator><creator>Chumak, Vira</creator><creator>Bujko, Kamila</creator><creator>Ratajczak, Janina</creator><creator>Brzezniakiewicz-Janus, Katarzyna</creator><creator>Kucia, Magdalena</creator><creator>Ratajczak, Mariusz Z.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9110-5048</orcidid><orcidid>https://orcid.org/0000-0002-0071-0198</orcidid></search><sort><creationdate>20220401</creationdate><title>Novel Evidence That Alternative Pathway of Complement Cascade Activation is Required for Optimal Homing and Engraftment of Hematopoietic Stem/progenitor Cells</title><author>Adamiak, Mateusz ; Ciechanowicz, Andrzej ; Chumak, Vira ; Bujko, Kamila ; Ratajczak, Janina ; Brzezniakiewicz-Janus, Katarzyna ; Kucia, Magdalena ; Ratajczak, Mariusz Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-5100318a6f1876a1340058e93c5c38a2b0c2986075735520e229937e18e0ee673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alternative pathway</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Bone marrow</topic><topic>Bone Marrow - metabolism</topic><topic>Bone marrow transplantation</topic><topic>Cell Biology</topic><topic>Cell migration</topic><topic>Complement Activation</topic><topic>Complement component C3</topic><topic>Complement component C5</topic><topic>Cytokines</topic><topic>Granulocytes</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Hematopoietic Stem Cells</topic><topic>Homing behavior</topic><topic>Immune system</topic><topic>Inflammasomes</topic><topic>Inflammasomes - metabolism</topic><topic>Inflammation</topic><topic>Innate immunity</topic><topic>Laboratories</topic><topic>Life Sciences</topic><topic>Metabolic pathways</topic><topic>Mice</topic><topic>Progenitor cells</topic><topic>Proteins</topic><topic>Proteomics</topic><topic>Radiation</topic><topic>Regenerative Medicine/Tissue Engineering</topic><topic>Signal transduction</topic><topic>Stem Cells</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adamiak, Mateusz</creatorcontrib><creatorcontrib>Ciechanowicz, Andrzej</creatorcontrib><creatorcontrib>Chumak, Vira</creatorcontrib><creatorcontrib>Bujko, Kamila</creatorcontrib><creatorcontrib>Ratajczak, Janina</creatorcontrib><creatorcontrib>Brzezniakiewicz-Janus, Katarzyna</creatorcontrib><creatorcontrib>Kucia, Magdalena</creatorcontrib><creatorcontrib>Ratajczak, Mariusz Z.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Stem cell reviews and reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adamiak, Mateusz</au><au>Ciechanowicz, Andrzej</au><au>Chumak, Vira</au><au>Bujko, Kamila</au><au>Ratajczak, Janina</au><au>Brzezniakiewicz-Janus, Katarzyna</au><au>Kucia, Magdalena</au><au>Ratajczak, Mariusz Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel Evidence That Alternative Pathway of Complement Cascade Activation is Required for Optimal Homing and Engraftment of Hematopoietic Stem/progenitor Cells</atitle><jtitle>Stem cell reviews and reports</jtitle><stitle>Stem Cell Rev and Rep</stitle><addtitle>Stem Cell Rev Rep</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>18</volume><issue>4</issue><spage>1355</spage><epage>1365</epage><pages>1355-1365</pages><issn>2629-3269</issn><eissn>2629-3277</eissn><abstract>We reported in the past that activation of the third (C3) and fifth element (C5) of complement cascade (ComC) is required for a proper homing and engraftment of transplanted hematopoietic stem/progenitor cells (HSPCs). Since myeloablative conditioning for transplantation triggers in recipient bone marrow (BM) state of sterile inflammation, we have become interested in the role of complement in this process and the potential involvement of alternative pathway of ComC activation. We noticed that factor B deficient mice (FB-KO) that do not activate properly alternative pathway, engraft poorly with BM cells from normal wild type (WT) mice. We observed defects both in homing and engraftment of transplanted HSPCs. To shed more light on these phenomena, we found that myeloablative lethal irradiation conditioning for transplantation activates purinergic signaling, ComC, and Nlrp3 inflammasome in WT mice, which is significantly impaired in FB-KO animals. Our proteomics analysis revealed that conditioned for transplantation lethally irradiated FB-KO compared to normal control animals have lower expression of several proteins involved in positive regulation of cell migration, trans-endothelial migration, immune system, cellular signaling protein, and metabolic pathways. Overall, our recent study further supports the role of innate immunity in homing and engraftment of HSPCs.
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| subjects | Alternative pathway Animals Biomedical and Life Sciences Biomedical Engineering and Bioengineering Bone marrow Bone Marrow - metabolism Bone marrow transplantation Cell Biology Cell migration Complement Activation Complement component C3 Complement component C5 Cytokines Granulocytes Hematology Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells Homing behavior Immune system Inflammasomes Inflammasomes - metabolism Inflammation Innate immunity Laboratories Life Sciences Metabolic pathways Mice Progenitor cells Proteins Proteomics Radiation Regenerative Medicine/Tissue Engineering Signal transduction Stem Cells Transplants & implants |
| title | Novel Evidence That Alternative Pathway of Complement Cascade Activation is Required for Optimal Homing and Engraftment of Hematopoietic Stem/progenitor Cells |
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