Detection and Classification of Colorectal Polyp Using Deep Learning

Colorectal Cancer (CRC) is the third most dangerous cancer in the world and also increasing day by day. So, timely and accurate diagnosis is required to save the life of patients. Cancer grows from polyps which can be either cancerous or noncancerous. So, if the cancerous polyps are detected accurat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:BioMed research international 2022, Vol.2022 (1), p.2805607-2805607
Hauptverfasser: Tanwar, Sushama, Vijayalakshmi, S., Sabharwal, Munish, Kaur, Manjit, AlZubi, Ahmad Ali, Lee, Heung-No
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 2805607
container_issue 1
container_start_page 2805607
container_title BioMed research international
container_volume 2022
creator Tanwar, Sushama
Vijayalakshmi, S.
Sabharwal, Munish
Kaur, Manjit
AlZubi, Ahmad Ali
Lee, Heung-No
description Colorectal Cancer (CRC) is the third most dangerous cancer in the world and also increasing day by day. So, timely and accurate diagnosis is required to save the life of patients. Cancer grows from polyps which can be either cancerous or noncancerous. So, if the cancerous polyps are detected accurately and removed on time, then the dangerous consequences of cancer can be reduced to a large extent. The colonoscopy is used to detect the presence of colorectal polyps. However, manual examinations performed by experts are prone to various errors. Therefore, some researchers have utilized machine and deep learning-based models to automate the diagnosis process. However, existing models suffer from overfitting and gradient vanishing problems. To overcome these problems, a convolutional neural network- (CNN-) based deep learning model is proposed. Initially, guided image filter and dynamic histogram equalization approaches are used to filter and enhance the colonoscopy images. Thereafter, Single Shot MultiBox Detector (SSD) is used to efficiently detect and classify colorectal polyps from colonoscopy images. Finally, fully connected layers with dropouts are used to classify the polyp classes. Extensive experimental results on benchmark dataset show that the proposed model achieves significantly better results than the competitive models. The proposed model can detect and classify colorectal polyps from the colonoscopy images with 92% accuracy.
doi_str_mv 10.1155/2022/2805607
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9033358</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2655100357</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-e2925a33c24277381a1e78a610c0091bd98665cbc50664fab06d34025ae851c83</originalsourceid><addsrcrecordid>eNp9kU1LAzEQhoMottTePMuCF0HX5mOTzV4Eaf2Cgh7sOaTZbJuyTWqyq_Tfm9pa1INzyczkmZcZXgBOEbxGiNIBhhgPMIeUwfwAdDFBWcpQhg73OSEd0A9hAWNwxGDBjkGH0IyRghddMBrpRqvGOJtIWybDWoZgKqPkV8tVydDVzkdC1smLq9erZBKMnSUjrVfJWEtvY3UCjipZB93fvT0wub97HT6m4-eHp-HtOFVZxptU4wJTSYjCGc5zwpFEOueSIaggLNC0LDhjVE0VhYxllZxCVpIMxhnNKVKc9MDNVnfVTpe6VNo2XtZi5c1S-rVw0ojfP9bMxcy9iwISQuhG4GIn4N1bq0MjliYoXdfSatcGgRmlCEJC84ie_0EXrvU2nrehCC94jlmkrraU8i4Er6v9MgiKjUNi45DYORTxs58H7OFvPyJwuQXmxpbyw_wv9wlu3pZO</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2653898726</pqid></control><display><type>article</type><title>Detection and Classification of Colorectal Polyp Using Deep Learning</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Tanwar, Sushama ; Vijayalakshmi, S. ; Sabharwal, Munish ; Kaur, Manjit ; AlZubi, Ahmad Ali ; Lee, Heung-No</creator><contributor>Parameshachari, B. D. ; B D Parameshachari</contributor><creatorcontrib>Tanwar, Sushama ; Vijayalakshmi, S. ; Sabharwal, Munish ; Kaur, Manjit ; AlZubi, Ahmad Ali ; Lee, Heung-No ; Parameshachari, B. D. ; B D Parameshachari</creatorcontrib><description>Colorectal Cancer (CRC) is the third most dangerous cancer in the world and also increasing day by day. So, timely and accurate diagnosis is required to save the life of patients. Cancer grows from polyps which can be either cancerous or noncancerous. So, if the cancerous polyps are detected accurately and removed on time, then the dangerous consequences of cancer can be reduced to a large extent. The colonoscopy is used to detect the presence of colorectal polyps. However, manual examinations performed by experts are prone to various errors. Therefore, some researchers have utilized machine and deep learning-based models to automate the diagnosis process. However, existing models suffer from overfitting and gradient vanishing problems. To overcome these problems, a convolutional neural network- (CNN-) based deep learning model is proposed. Initially, guided image filter and dynamic histogram equalization approaches are used to filter and enhance the colonoscopy images. Thereafter, Single Shot MultiBox Detector (SSD) is used to efficiently detect and classify colorectal polyps from colonoscopy images. Finally, fully connected layers with dropouts are used to classify the polyp classes. Extensive experimental results on benchmark dataset show that the proposed model achieves significantly better results than the competitive models. The proposed model can detect and classify colorectal polyps from the colonoscopy images with 92% accuracy.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2022/2805607</identifier><identifier>PMID: 35463989</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Accuracy ; Artificial neural networks ; Automation ; Cancer ; Classification ; Colonic Polyps - diagnostic imaging ; Colonoscopy ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - diagnostic imaging ; Crohn's disease ; Datasets ; Deep Learning ; Diagnosis ; Discriminant analysis ; Endoscopy ; Equalization ; Histograms ; Humans ; Image classification ; Image enhancement ; Image filters ; Inflammatory bowel disease ; Machine learning ; Medical imaging ; Medical screening ; Neural networks ; Neural Networks, Computer ; Polyps ; Support vector machines ; Tumors ; Wavelet transforms</subject><ispartof>BioMed research international, 2022, Vol.2022 (1), p.2805607-2805607</ispartof><rights>Copyright © 2022 Sushama Tanwar et al.</rights><rights>Copyright © 2022 Sushama Tanwar et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Sushama Tanwar et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-e2925a33c24277381a1e78a610c0091bd98665cbc50664fab06d34025ae851c83</citedby><cites>FETCH-LOGICAL-c448t-e2925a33c24277381a1e78a610c0091bd98665cbc50664fab06d34025ae851c83</cites><orcidid>0000-0002-7338-6982 ; 0000-0001-8477-8319 ; 0000-0001-8528-5778</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033358/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033358/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35463989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Parameshachari, B. D.</contributor><contributor>B D Parameshachari</contributor><creatorcontrib>Tanwar, Sushama</creatorcontrib><creatorcontrib>Vijayalakshmi, S.</creatorcontrib><creatorcontrib>Sabharwal, Munish</creatorcontrib><creatorcontrib>Kaur, Manjit</creatorcontrib><creatorcontrib>AlZubi, Ahmad Ali</creatorcontrib><creatorcontrib>Lee, Heung-No</creatorcontrib><title>Detection and Classification of Colorectal Polyp Using Deep Learning</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Colorectal Cancer (CRC) is the third most dangerous cancer in the world and also increasing day by day. So, timely and accurate diagnosis is required to save the life of patients. Cancer grows from polyps which can be either cancerous or noncancerous. So, if the cancerous polyps are detected accurately and removed on time, then the dangerous consequences of cancer can be reduced to a large extent. The colonoscopy is used to detect the presence of colorectal polyps. However, manual examinations performed by experts are prone to various errors. Therefore, some researchers have utilized machine and deep learning-based models to automate the diagnosis process. However, existing models suffer from overfitting and gradient vanishing problems. To overcome these problems, a convolutional neural network- (CNN-) based deep learning model is proposed. Initially, guided image filter and dynamic histogram equalization approaches are used to filter and enhance the colonoscopy images. Thereafter, Single Shot MultiBox Detector (SSD) is used to efficiently detect and classify colorectal polyps from colonoscopy images. Finally, fully connected layers with dropouts are used to classify the polyp classes. Extensive experimental results on benchmark dataset show that the proposed model achieves significantly better results than the competitive models. The proposed model can detect and classify colorectal polyps from the colonoscopy images with 92% accuracy.</description><subject>Accuracy</subject><subject>Artificial neural networks</subject><subject>Automation</subject><subject>Cancer</subject><subject>Classification</subject><subject>Colonic Polyps - diagnostic imaging</subject><subject>Colonoscopy</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - diagnostic imaging</subject><subject>Crohn's disease</subject><subject>Datasets</subject><subject>Deep Learning</subject><subject>Diagnosis</subject><subject>Discriminant analysis</subject><subject>Endoscopy</subject><subject>Equalization</subject><subject>Histograms</subject><subject>Humans</subject><subject>Image classification</subject><subject>Image enhancement</subject><subject>Image filters</subject><subject>Inflammatory bowel disease</subject><subject>Machine learning</subject><subject>Medical imaging</subject><subject>Medical screening</subject><subject>Neural networks</subject><subject>Neural Networks, Computer</subject><subject>Polyps</subject><subject>Support vector machines</subject><subject>Tumors</subject><subject>Wavelet transforms</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1LAzEQhoMottTePMuCF0HX5mOTzV4Eaf2Cgh7sOaTZbJuyTWqyq_Tfm9pa1INzyczkmZcZXgBOEbxGiNIBhhgPMIeUwfwAdDFBWcpQhg73OSEd0A9hAWNwxGDBjkGH0IyRghddMBrpRqvGOJtIWybDWoZgKqPkV8tVydDVzkdC1smLq9erZBKMnSUjrVfJWEtvY3UCjipZB93fvT0wub97HT6m4-eHp-HtOFVZxptU4wJTSYjCGc5zwpFEOueSIaggLNC0LDhjVE0VhYxllZxCVpIMxhnNKVKc9MDNVnfVTpe6VNo2XtZi5c1S-rVw0ojfP9bMxcy9iwISQuhG4GIn4N1bq0MjliYoXdfSatcGgRmlCEJC84ie_0EXrvU2nrehCC94jlmkrraU8i4Er6v9MgiKjUNi45DYORTxs58H7OFvPyJwuQXmxpbyw_wv9wlu3pZO</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Tanwar, Sushama</creator><creator>Vijayalakshmi, S.</creator><creator>Sabharwal, Munish</creator><creator>Kaur, Manjit</creator><creator>AlZubi, Ahmad Ali</creator><creator>Lee, Heung-No</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7338-6982</orcidid><orcidid>https://orcid.org/0000-0001-8477-8319</orcidid><orcidid>https://orcid.org/0000-0001-8528-5778</orcidid></search><sort><creationdate>2022</creationdate><title>Detection and Classification of Colorectal Polyp Using Deep Learning</title><author>Tanwar, Sushama ; Vijayalakshmi, S. ; Sabharwal, Munish ; Kaur, Manjit ; AlZubi, Ahmad Ali ; Lee, Heung-No</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-e2925a33c24277381a1e78a610c0091bd98665cbc50664fab06d34025ae851c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Accuracy</topic><topic>Artificial neural networks</topic><topic>Automation</topic><topic>Cancer</topic><topic>Classification</topic><topic>Colonic Polyps - diagnostic imaging</topic><topic>Colonoscopy</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - diagnostic imaging</topic><topic>Crohn's disease</topic><topic>Datasets</topic><topic>Deep Learning</topic><topic>Diagnosis</topic><topic>Discriminant analysis</topic><topic>Endoscopy</topic><topic>Equalization</topic><topic>Histograms</topic><topic>Humans</topic><topic>Image classification</topic><topic>Image enhancement</topic><topic>Image filters</topic><topic>Inflammatory bowel disease</topic><topic>Machine learning</topic><topic>Medical imaging</topic><topic>Medical screening</topic><topic>Neural networks</topic><topic>Neural Networks, Computer</topic><topic>Polyps</topic><topic>Support vector machines</topic><topic>Tumors</topic><topic>Wavelet transforms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanwar, Sushama</creatorcontrib><creatorcontrib>Vijayalakshmi, S.</creatorcontrib><creatorcontrib>Sabharwal, Munish</creatorcontrib><creatorcontrib>Kaur, Manjit</creatorcontrib><creatorcontrib>AlZubi, Ahmad Ali</creatorcontrib><creatorcontrib>Lee, Heung-No</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Database‎ (1962 - current)</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East &amp; Africa Database</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanwar, Sushama</au><au>Vijayalakshmi, S.</au><au>Sabharwal, Munish</au><au>Kaur, Manjit</au><au>AlZubi, Ahmad Ali</au><au>Lee, Heung-No</au><au>Parameshachari, B. D.</au><au>B D Parameshachari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection and Classification of Colorectal Polyp Using Deep Learning</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><issue>1</issue><spage>2805607</spage><epage>2805607</epage><pages>2805607-2805607</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Colorectal Cancer (CRC) is the third most dangerous cancer in the world and also increasing day by day. So, timely and accurate diagnosis is required to save the life of patients. Cancer grows from polyps which can be either cancerous or noncancerous. So, if the cancerous polyps are detected accurately and removed on time, then the dangerous consequences of cancer can be reduced to a large extent. The colonoscopy is used to detect the presence of colorectal polyps. However, manual examinations performed by experts are prone to various errors. Therefore, some researchers have utilized machine and deep learning-based models to automate the diagnosis process. However, existing models suffer from overfitting and gradient vanishing problems. To overcome these problems, a convolutional neural network- (CNN-) based deep learning model is proposed. Initially, guided image filter and dynamic histogram equalization approaches are used to filter and enhance the colonoscopy images. Thereafter, Single Shot MultiBox Detector (SSD) is used to efficiently detect and classify colorectal polyps from colonoscopy images. Finally, fully connected layers with dropouts are used to classify the polyp classes. Extensive experimental results on benchmark dataset show that the proposed model achieves significantly better results than the competitive models. The proposed model can detect and classify colorectal polyps from the colonoscopy images with 92% accuracy.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35463989</pmid><doi>10.1155/2022/2805607</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7338-6982</orcidid><orcidid>https://orcid.org/0000-0001-8477-8319</orcidid><orcidid>https://orcid.org/0000-0001-8528-5778</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2314-6133
ispartof BioMed research international, 2022, Vol.2022 (1), p.2805607-2805607
issn 2314-6133
2314-6141
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9033358
source MEDLINE; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access
subjects Accuracy
Artificial neural networks
Automation
Cancer
Classification
Colonic Polyps - diagnostic imaging
Colonoscopy
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - diagnostic imaging
Crohn's disease
Datasets
Deep Learning
Diagnosis
Discriminant analysis
Endoscopy
Equalization
Histograms
Humans
Image classification
Image enhancement
Image filters
Inflammatory bowel disease
Machine learning
Medical imaging
Medical screening
Neural networks
Neural Networks, Computer
Polyps
Support vector machines
Tumors
Wavelet transforms
title Detection and Classification of Colorectal Polyp Using Deep Learning
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T09%3A06%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Detection%20and%20Classification%20of%20Colorectal%20Polyp%20Using%20Deep%20Learning&rft.jtitle=BioMed%20research%20international&rft.au=Tanwar,%20Sushama&rft.date=2022&rft.volume=2022&rft.issue=1&rft.spage=2805607&rft.epage=2805607&rft.pages=2805607-2805607&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2022/2805607&rft_dat=%3Cproquest_pubme%3E2655100357%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2653898726&rft_id=info:pmid/35463989&rfr_iscdi=true