Novel Protein-Protein Interactions Highlighting the Crosstalk between Hypoplastic Left Heart Syndrome, Ciliopathies and Neurodevelopmental Delays

Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) affecting 1 in 5000 newborns. We constructed the interactome of 74 HLHS-associated genes identified from a large-scale mouse mutagenesis screen, augmenting it with 408 novel protein-protein interactions (PPIs) using ou...

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Veröffentlicht in:	Genes 2022-04, Vol.13 (4), p.627
Hauptverfasser:	Karunakaran, Kalyani B, Gabriel, George C, Balakrishnan, Narayanaswamy, Lo, Cecilia W, Ganapathiraju, Madhavi K
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Cardiomyocytes Ciliopathies - metabolism Congenital diseases Coronary artery disease Coronary vessels Diabetes mellitus Endoplasmic reticulum Etiology Gene expression Genomes Genomics Heart Heart diseases Humans Hypoplastic Left Heart Syndrome - genetics Hypoplastic Left Heart Syndrome - metabolism Induced Pluripotent Stem Cells - metabolism Infant, Newborn Intellectual disabilities Liver diseases Mice Microcephaly - genetics Microcephaly - metabolism Microencephaly Mortality Mutagenesis Mutation Myocytes, Cardiac - metabolism Neonates Nervous System Malformations Neurodegenerative diseases Protein interaction Proteins Pulmonary arteries Transcription factors
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