A Positive Correlation between Steroid Injections and Cuff Tendon Tears: A Cohort Study Using a Clinical Database
This cohort study aimed to investigate the association between steroid injections for shoulder diseases and the increased incidence of cuff tendon tears. The Kaohsiung Veterans General Hospital clinical database was used in this study. Patients were enrolled using the corresponding diagnostic codes...
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| Veröffentlicht in: | International journal of environmental research and public health 2022-04, Vol.19 (8), p.4520 |
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| creator | Lin, Ching-Yueh Huang, Shih-Chung Tzou, Shiow-Jyu Yin, Chun-Hao Chen, Jin-Shuen Chen, Yao-Shen Chang, Shin-Tsu |
| description | This cohort study aimed to investigate the association between steroid injections for shoulder diseases and the increased incidence of cuff tendon tears. The Kaohsiung Veterans General Hospital clinical database was used in this study. Patients were enrolled using the corresponding diagnostic codes for shoulder diseases. Patients who received steroid injections were included in the case group, and those without steroid injections were included in the control group. The outcome measure was the occurrence of cuff tendon tears during the study period. Adjusted hazard ratios for outcomes were calculated using Cox regression analysis adjusted for sex, age, and comorbidities. Of the 1025 patients with shoulder disease, 205 were in the case group and 820 were in the control group. The incidence of cuff tendon tears was 9.8% in patients who received steroid injections (p < 0.001). The adjusted hazard ratios for steroid injections, smoking, and chronic liver disease were 7.44 (p < 0.001), 2.40 (p = 0.046), 3.25 (p = 0.007), respectively. Steroid injections on the shoulder were associated with a raised risk of cuff tendon tears by 7.44 times compared to non-injection. The incidence of cuff tendon tears increased by 3.25 times with concurrent chronic liver disease and by 2.4 times with smoking. |
| doi_str_mv | 10.3390/ijerph19084520 |
| format | Article |
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The Kaohsiung Veterans General Hospital clinical database was used in this study. Patients were enrolled using the corresponding diagnostic codes for shoulder diseases. Patients who received steroid injections were included in the case group, and those without steroid injections were included in the control group. The outcome measure was the occurrence of cuff tendon tears during the study period. Adjusted hazard ratios for outcomes were calculated using Cox regression analysis adjusted for sex, age, and comorbidities. Of the 1025 patients with shoulder disease, 205 were in the case group and 820 were in the control group. The incidence of cuff tendon tears was 9.8% in patients who received steroid injections (p < 0.001). The adjusted hazard ratios for steroid injections, smoking, and chronic liver disease were 7.44 (p < 0.001), 2.40 (p = 0.046), 3.25 (p = 0.007), respectively. Steroid injections on the shoulder were associated with a raised risk of cuff tendon tears by 7.44 times compared to non-injection. The incidence of cuff tendon tears increased by 3.25 times with concurrent chronic liver disease and by 2.4 times with smoking.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph19084520</identifier><identifier>PMID: 35457390</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Biomechanics ; Codes ; Cohort analysis ; Cohort Studies ; Collagen ; Enrollments ; Fibroblasts ; Humans ; Hypertension ; Injuries ; Liver ; Liver diseases ; Manipulative therapy ; Osteoporosis ; Pain ; Patients ; Physical therapy ; Regression analysis ; Rheumatism ; Rotator cuff ; Rotator Cuff Injuries - epidemiology ; Shoulder ; Smoking ; Software ; Steroids ; Steroids - adverse effects ; Tendons</subject><ispartof>International journal of environmental research and public health, 2022-04, Vol.19 (8), p.4520</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3330-1c9e710ea37e40c247586cd0bfc54824d56d9d1ede15b0431ab18fe4e391f4df3</citedby><cites>FETCH-LOGICAL-c3330-1c9e710ea37e40c247586cd0bfc54824d56d9d1ede15b0431ab18fe4e391f4df3</cites><orcidid>0000-0001-7159-9119 ; 0000-0003-4005-2094</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031762/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031762/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35457390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Ching-Yueh</creatorcontrib><creatorcontrib>Huang, Shih-Chung</creatorcontrib><creatorcontrib>Tzou, Shiow-Jyu</creatorcontrib><creatorcontrib>Yin, Chun-Hao</creatorcontrib><creatorcontrib>Chen, Jin-Shuen</creatorcontrib><creatorcontrib>Chen, Yao-Shen</creatorcontrib><creatorcontrib>Chang, Shin-Tsu</creatorcontrib><title>A Positive Correlation between Steroid Injections and Cuff Tendon Tears: A Cohort Study Using a Clinical Database</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>This cohort study aimed to investigate the association between steroid injections for shoulder diseases and the increased incidence of cuff tendon tears. The Kaohsiung Veterans General Hospital clinical database was used in this study. Patients were enrolled using the corresponding diagnostic codes for shoulder diseases. Patients who received steroid injections were included in the case group, and those without steroid injections were included in the control group. The outcome measure was the occurrence of cuff tendon tears during the study period. Adjusted hazard ratios for outcomes were calculated using Cox regression analysis adjusted for sex, age, and comorbidities. Of the 1025 patients with shoulder disease, 205 were in the case group and 820 were in the control group. The incidence of cuff tendon tears was 9.8% in patients who received steroid injections (p < 0.001). The adjusted hazard ratios for steroid injections, smoking, and chronic liver disease were 7.44 (p < 0.001), 2.40 (p = 0.046), 3.25 (p = 0.007), respectively. Steroid injections on the shoulder were associated with a raised risk of cuff tendon tears by 7.44 times compared to non-injection. The incidence of cuff tendon tears increased by 3.25 times with concurrent chronic liver disease and by 2.4 times with smoking.</description><subject>Age</subject><subject>Biomechanics</subject><subject>Codes</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Collagen</subject><subject>Enrollments</subject><subject>Fibroblasts</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Injuries</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Manipulative therapy</subject><subject>Osteoporosis</subject><subject>Pain</subject><subject>Patients</subject><subject>Physical therapy</subject><subject>Regression analysis</subject><subject>Rheumatism</subject><subject>Rotator cuff</subject><subject>Rotator Cuff Injuries - epidemiology</subject><subject>Shoulder</subject><subject>Smoking</subject><subject>Software</subject><subject>Steroids</subject><subject>Steroids - adverse effects</subject><subject>Tendons</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpVkUtLAzEUhYMovrcuJeC6mkwymYkLoYyvQkHBug6Z5E6bMiZtMqP47x3xQbu6F-53zj1wEDqj5JIxSa7cEuJqQSUpeZ6RHXRIhSAjLgjd3dgP0FFKS0JYyYXcRwcs53kxyA_ReoyfQ3KdewdchRih1Z0LHtfQfQB4_NJBDM7iiV-C-b4krL3FVd80eAbeDugMdEzXeDzoFyF2g6S3n_g1OT_HGlet887oFt_qTtc6wQnaa3Sb4PR3HqPX-7tZ9TiaPj1MqvF0ZBhjZESNhIIS0KwATkzGi7wUxpK6MTkvM25zYaWlYIHmNeGM6pqWDXBgkjbcNuwY3fz4rvr6DawB30XdqlV0bzp-qqCd2r54t1Dz8K4kYbQQ2WBw8WsQw7qH1Kll6KMfMqtM5JkspGByoC5_KBNDShGa_w-UqO-K1HZFg-B8M9c__tcJ-wIr8o7u</recordid><startdate>20220408</startdate><enddate>20220408</enddate><creator>Lin, Ching-Yueh</creator><creator>Huang, Shih-Chung</creator><creator>Tzou, Shiow-Jyu</creator><creator>Yin, Chun-Hao</creator><creator>Chen, Jin-Shuen</creator><creator>Chen, Yao-Shen</creator><creator>Chang, Shin-Tsu</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7159-9119</orcidid><orcidid>https://orcid.org/0000-0003-4005-2094</orcidid></search><sort><creationdate>20220408</creationdate><title>A Positive Correlation between Steroid Injections and Cuff Tendon Tears: A Cohort Study Using a Clinical Database</title><author>Lin, Ching-Yueh ; 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Steroid injections on the shoulder were associated with a raised risk of cuff tendon tears by 7.44 times compared to non-injection. The incidence of cuff tendon tears increased by 3.25 times with concurrent chronic liver disease and by 2.4 times with smoking.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35457390</pmid><doi>10.3390/ijerph19084520</doi><orcidid>https://orcid.org/0000-0001-7159-9119</orcidid><orcidid>https://orcid.org/0000-0003-4005-2094</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; PubMed Central Open Access |
| subjects | Age Biomechanics Codes Cohort analysis Cohort Studies Collagen Enrollments Fibroblasts Humans Hypertension Injuries Liver Liver diseases Manipulative therapy Osteoporosis Pain Patients Physical therapy Regression analysis Rheumatism Rotator cuff Rotator Cuff Injuries - epidemiology Shoulder Smoking Software Steroids Steroids - adverse effects Tendons |
| title | A Positive Correlation between Steroid Injections and Cuff Tendon Tears: A Cohort Study Using a Clinical Database |
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