Differential Nanoscale Topography Dedicates Osteocyte-Manipulated Osteogenesis via Regulation of the TGF-β Signaling Pathway

Osteocytes function as the master orchestrator of bone remodeling activity in the telophase of osseointegration. However, most contemporary studies focus on the manipulation of osteoblast and/or osteoclast functionality via implant surface engineering, which neglects the pivotal role of osteocytes i...

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Veröffentlicht in:	International journal of molecular sciences 2022-04, Vol.23 (8), p.4212
Hauptverfasser:	Cui, Jingyuan, Yang, Yaru, Chen, Peiru, Hang, Ruiqiang, Xiao, Yin, Liu, Xueting, Zhang, Lixin, Sun, Hui, Bai, Long
Format:	Artikel
Sprache:	eng
Schlagworte:	Behavior Biocompatibility Biomedical materials Bone growth Bone implants Bone remodeling Cell adhesion & migration Gene expression Genetic engineering In vivo methods and tests Mineralization Morphology Osseointegration Osteoblasts - metabolism Osteocytes Osteocytes - metabolism Osteogenesis Physicochemical properties Proteins Signal Transduction Topography Transcriptomes Transforming Growth Factor beta - metabolism Transplants & implants
Online-Zugang:	Volltext
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