Introduction of NADH-dependent nitrate assimilation in Synechococcus sp. PCC 7002 improves photosynthetic production of 2-methyl-1-butanol and isobutanol

Cyanobacteria hold promise for renewable chemical production due to their photosynthetic nature, but engineered strains frequently display poor production characteristics. These difficulties likely arise in part due to the distinctive photoautotrophic metabolism of cyanobacteria. In this work, we ap...

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Veröffentlicht in:	Metabolic engineering 2022-01, Vol.69, p.87-97
Hauptverfasser:	Purdy, Hugh M., Pfleger, Brian F., Reed, Jennifer L.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Butanol - metabolism 2-methyl-1-butanol BASIC BIOLOGICAL SCIENCES Butanols Cyanobacteria Genome-scale metabolic model Isobutanol NAD - genetics NAD - metabolism Nitrate assimilation Nitrates - metabolism Strain design Synechococcus - genetics Synechococcus - metabolism
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