Synthesis, Characterization and Nanoformulation of Novel Sulfonamide-1,2,3-triazole Molecular Conjugates as Potent Antiparasitic Agents
( ) is a highly prevalent parasite that has no gold standard treatment due to the poor action or the numerous side effects. Focused sulfonamide-1,2,3-triazole hybrids were wisely designed and synthesized via copper catalyzed 1,3-dipolar cycloaddition approach between prop-2-yn-1-alcohol and sulfa dr...
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| Veröffentlicht in: | International journal of molecular sciences 2022-04, Vol.23 (8), p.4241 |
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| creator | Aljohani, Faizah S Rezki, Nadjet Aouad, Mohamed R Elwakil, Bassma H Hagar, Mohamed Sheta, Eman Hussein Mogahed, Nermine Mogahed Fawzy Bardaweel, Sanaa K Hagras, Nancy Abd-Elkader |
| description | (
) is a highly prevalent parasite that has no gold standard treatment due to the poor action or the numerous side effects. Focused sulfonamide-1,2,3-triazole hybrids
were wisely designed and synthesized via copper catalyzed 1,3-dipolar cycloaddition approach between prop-2-yn-1-alcohol
and sulfa drug azides
. The newly synthesized click products were fully characterized using different spectroscopic experiments and were loaded onto chitosan nanoparticles to form novel nanoformulations for further anti-Toxoplasma investigation. The current study proved the anti-Toxoplasma effectiveness of all examined compounds in experimentally infected mice. Relative to sulfadiazine, the synthesized sulfonamide-1,2,3-triazole (
) nanoformulae demonstrated the most promising result for toxoplasmosis treatment as it resulted in 100% survival, 100% parasite reduction along with the remarkable histopathological improvement in all the studied organs. |
| doi_str_mv | 10.3390/ijms23084241 |
| format | Article |
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) is a highly prevalent parasite that has no gold standard treatment due to the poor action or the numerous side effects. Focused sulfonamide-1,2,3-triazole hybrids
were wisely designed and synthesized via copper catalyzed 1,3-dipolar cycloaddition approach between prop-2-yn-1-alcohol
and sulfa drug azides
. The newly synthesized click products were fully characterized using different spectroscopic experiments and were loaded onto chitosan nanoparticles to form novel nanoformulations for further anti-Toxoplasma investigation. The current study proved the anti-Toxoplasma effectiveness of all examined compounds in experimentally infected mice. Relative to sulfadiazine, the synthesized sulfonamide-1,2,3-triazole (
) nanoformulae demonstrated the most promising result for toxoplasmosis treatment as it resulted in 100% survival, 100% parasite reduction along with the remarkable histopathological improvement in all the studied organs.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms23084241</identifier><identifier>PMID: 35457059</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Antibiotics ; Antifungal agents ; Antiparasitic agents ; Antiparasitic Agents - pharmacology ; Chitosan ; Cycloaddition ; Disease ; Drug dosages ; Hybrids ; Infections ; Mice ; Nanoparticles ; Organs ; Parasites ; Permeability ; Sulfadiazine ; Sulfonamides ; Sulfonamides - pharmacology ; Toxoplasma ; Toxoplasmosis ; Triazoles ; Triazoles - chemistry ; Virulence</subject><ispartof>International journal of molecular sciences, 2022-04, Vol.23 (8), p.4241</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-a23b553709f0735d9cb37d516de2cc1e9dab51b1420293be6cd2846ccb045ee3</citedby><cites>FETCH-LOGICAL-c342t-a23b553709f0735d9cb37d516de2cc1e9dab51b1420293be6cd2846ccb045ee3</cites><orcidid>0000-0001-9018-5229 ; 0000-0001-7018-6654 ; 0000-0003-0169-7738 ; 0000-0002-4823-0708 ; 0000-0001-8330-1738 ; 0000-0001-6596-3156 ; 0000-0003-3185-8504</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025934/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025934/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35457059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aljohani, Faizah S</creatorcontrib><creatorcontrib>Rezki, Nadjet</creatorcontrib><creatorcontrib>Aouad, Mohamed R</creatorcontrib><creatorcontrib>Elwakil, Bassma H</creatorcontrib><creatorcontrib>Hagar, Mohamed</creatorcontrib><creatorcontrib>Sheta, Eman</creatorcontrib><creatorcontrib>Hussein Mogahed, Nermine Mogahed Fawzy</creatorcontrib><creatorcontrib>Bardaweel, Sanaa K</creatorcontrib><creatorcontrib>Hagras, Nancy Abd-Elkader</creatorcontrib><title>Synthesis, Characterization and Nanoformulation of Novel Sulfonamide-1,2,3-triazole Molecular Conjugates as Potent Antiparasitic Agents</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>(
) is a highly prevalent parasite that has no gold standard treatment due to the poor action or the numerous side effects. Focused sulfonamide-1,2,3-triazole hybrids
were wisely designed and synthesized via copper catalyzed 1,3-dipolar cycloaddition approach between prop-2-yn-1-alcohol
and sulfa drug azides
. The newly synthesized click products were fully characterized using different spectroscopic experiments and were loaded onto chitosan nanoparticles to form novel nanoformulations for further anti-Toxoplasma investigation. The current study proved the anti-Toxoplasma effectiveness of all examined compounds in experimentally infected mice. Relative to sulfadiazine, the synthesized sulfonamide-1,2,3-triazole (
) nanoformulae demonstrated the most promising result for toxoplasmosis treatment as it resulted in 100% survival, 100% parasite reduction along with the remarkable histopathological improvement in all the studied organs.</description><subject>Animals</subject><subject>Antibiotics</subject><subject>Antifungal agents</subject><subject>Antiparasitic agents</subject><subject>Antiparasitic Agents - pharmacology</subject><subject>Chitosan</subject><subject>Cycloaddition</subject><subject>Disease</subject><subject>Drug dosages</subject><subject>Hybrids</subject><subject>Infections</subject><subject>Mice</subject><subject>Nanoparticles</subject><subject>Organs</subject><subject>Parasites</subject><subject>Permeability</subject><subject>Sulfadiazine</subject><subject>Sulfonamides</subject><subject>Sulfonamides - pharmacology</subject><subject>Toxoplasma</subject><subject>Toxoplasmosis</subject><subject>Triazoles</subject><subject>Triazoles - chemistry</subject><subject>Virulence</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUtrGzEUhUVpaBK3u66LoJsuPIlGjxlrUzCmeYCTFpK90Gju2DIzkitpAskfyN-OjNPgdCOJq0_33KOD0NeSnDEmybndDJEyMuOUlx_QSckpLQip6o8H52N0GuOGEMqokJ_QMRNc1ETIE_R89-jSGqKNU7xY66BNgmCfdLLeYe1afKud73wYxn5f8x2-9Q_Q47ux77zTg22hKKd0yooUrH7yPeCbvJj8IOCFd5txpRNErCP-4xO4hOcu2W2WijZZg-erXIuf0VGn-whfXvcJur_4db-4Kpa_L68X82VhGKep0JQ1QrCayI7UTLTSNKxuRVm1QI0pQba6EWWTjRMqWQOVaemMV8Y0hAsANkE_9223YzNAa7J00L3aBjvo8Ki8tur9jbNrtfIPSpL8c4znBj9eGwT_d4SY1GCjgb7XDvwYFa0Ez4pCzjL6_T9048fgsrsdRaVkVQ5kgqZ7ygQfY4DubZiSqF3A6jDgjH87NPAG_0uUvQDkUKRW</recordid><startdate>20220411</startdate><enddate>20220411</enddate><creator>Aljohani, Faizah S</creator><creator>Rezki, Nadjet</creator><creator>Aouad, Mohamed R</creator><creator>Elwakil, Bassma H</creator><creator>Hagar, Mohamed</creator><creator>Sheta, Eman</creator><creator>Hussein Mogahed, Nermine Mogahed Fawzy</creator><creator>Bardaweel, Sanaa K</creator><creator>Hagras, Nancy Abd-Elkader</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9018-5229</orcidid><orcidid>https://orcid.org/0000-0001-7018-6654</orcidid><orcidid>https://orcid.org/0000-0003-0169-7738</orcidid><orcidid>https://orcid.org/0000-0002-4823-0708</orcidid><orcidid>https://orcid.org/0000-0001-8330-1738</orcidid><orcidid>https://orcid.org/0000-0001-6596-3156</orcidid><orcidid>https://orcid.org/0000-0003-3185-8504</orcidid></search><sort><creationdate>20220411</creationdate><title>Synthesis, Characterization and Nanoformulation of Novel Sulfonamide-1,2,3-triazole Molecular Conjugates as Potent Antiparasitic Agents</title><author>Aljohani, Faizah S ; 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) is a highly prevalent parasite that has no gold standard treatment due to the poor action or the numerous side effects. Focused sulfonamide-1,2,3-triazole hybrids
were wisely designed and synthesized via copper catalyzed 1,3-dipolar cycloaddition approach between prop-2-yn-1-alcohol
and sulfa drug azides
. The newly synthesized click products were fully characterized using different spectroscopic experiments and were loaded onto chitosan nanoparticles to form novel nanoformulations for further anti-Toxoplasma investigation. The current study proved the anti-Toxoplasma effectiveness of all examined compounds in experimentally infected mice. Relative to sulfadiazine, the synthesized sulfonamide-1,2,3-triazole (
) nanoformulae demonstrated the most promising result for toxoplasmosis treatment as it resulted in 100% survival, 100% parasite reduction along with the remarkable histopathological improvement in all the studied organs.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35457059</pmid><doi>10.3390/ijms23084241</doi><orcidid>https://orcid.org/0000-0001-9018-5229</orcidid><orcidid>https://orcid.org/0000-0001-7018-6654</orcidid><orcidid>https://orcid.org/0000-0003-0169-7738</orcidid><orcidid>https://orcid.org/0000-0002-4823-0708</orcidid><orcidid>https://orcid.org/0000-0001-8330-1738</orcidid><orcidid>https://orcid.org/0000-0001-6596-3156</orcidid><orcidid>https://orcid.org/0000-0003-3185-8504</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Antibiotics Antifungal agents Antiparasitic agents Antiparasitic Agents - pharmacology Chitosan Cycloaddition Disease Drug dosages Hybrids Infections Mice Nanoparticles Organs Parasites Permeability Sulfadiazine Sulfonamides Sulfonamides - pharmacology Toxoplasma Toxoplasmosis Triazoles Triazoles - chemistry Virulence |
| title | Synthesis, Characterization and Nanoformulation of Novel Sulfonamide-1,2,3-triazole Molecular Conjugates as Potent Antiparasitic Agents |
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