Chinese expert consensus on conversion therapy for hepatocellular carcinoma (2021 edition)
Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma (HCC) have resulted in improved response rates. This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to...
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| Veröffentlicht in: | Hepatobiliary surgery and nutrition 2022-04, Vol.11 (2), p.227-252 |
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| creator | Sun, Hui-Chuan Zhou, Jian Wang, Zheng Liu, Xiufeng Xie, Qing Jia, Weidong Zhao, Ming Bi, Xinyu Li, Gong Bai, Xueli Ji, Yuan Xu, Li Zhu, Xiao-Dong Bai, Dousheng Chen, Yajin Chen, Yongjun Dai, Chaoliu Guo, Rongping Guo, Wenzhi Hao, Chunyi Huang, Tao Huang, Zhiyong Li, Deyu Li, Gang Li, Tao Li, Xiangcheng Li, Guangming Liang, Xiao Liu, Jingfeng Liu, Fubao Lu, Shichun Lu, Zheng Lv, Weifu Mao, Yilei Shao, Guoliang Shi, Yinghong Song, Tianqiang Tan, Guang Tang, Yunqiang Tao, Kaishan Wan, Chidan Wang, Guangyi Wang, Lu Wang, Shunxiang Wen, Tianfu Xing, Baocai Xiang, Bangde Yan, Sheng Yang, Dinghua Yin, Guowen Yin, Tao Yin, Zhenyu Yu, Zhengping Zhang, Bixiang Zhang, Jialin Zhang, Shuijun Zhang, Ti Zhang, Yamin Zhang, Yubao Zhang, Aibin Zhao, Haitao Zhou, Ledu Zhang, Wu Zhu, Zhenyu Qin, Shukui Shen, Feng Cai, Xiujun Teng, Gaojun Cai, Jianqiang Chen, Minshan Li, Qiang Liu, Lianxin Wang, Weilin Liang, Tingbo Dong, Jiahong Chen, Xiaoping Wang, Xuehao Zheng, Shusen Fan, Jia |
| description | Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma (HCC) have resulted in improved response rates. This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection, a 'conversion therapy' strategy. However, conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed. Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice. Evidence review: Many research centers in China have accumulated significant experience implementing HCC conversion therapy. Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC; however, there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields. In order to summarize and learn from past experience and review current challenges, the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma (2021 Edition) was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice. Sixteen consensus statements on the implementation of conversion therapy for HCC were developed. The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. |
| doi_str_mv | 10.21037/hbsn-21-328 |
| format | Article |
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This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection, a 'conversion therapy' strategy. However, conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed. Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice. Evidence review: Many research centers in China have accumulated significant experience implementing HCC conversion therapy. Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC; however, there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields. In order to summarize and learn from past experience and review current challenges, the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma (2021 Edition) was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice. Sixteen consensus statements on the implementation of conversion therapy for HCC were developed. The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.</description><identifier>ISSN: 2304-3881</identifier><identifier>EISSN: 2304-389X</identifier><identifier>DOI: 10.21037/hbsn-21-328</identifier><identifier>PMID: 35464283</identifier><language>eng</language><publisher>China (Republic : 1949- ): AME Publishing Company</publisher><subject>Review</subject><ispartof>Hepatobiliary surgery and nutrition, 2022-04, Vol.11 (2), p.227-252</ispartof><rights>2022 Hepatobiliary Surgery and Nutrition. All rights reserved.</rights><rights>2022 Hepatobiliary Surgery and Nutrition. All rights reserved. 2022 Hepatobiliary Surgery and Nutrition.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-744125bdf8954cdcb504ad1b08684193e0e29acb2510ffb842b3a1da9a2cddd13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023831/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023831/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35464283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Hui-Chuan</creatorcontrib><creatorcontrib>Zhou, Jian</creatorcontrib><creatorcontrib>Wang, Zheng</creatorcontrib><creatorcontrib>Liu, Xiufeng</creatorcontrib><creatorcontrib>Xie, Qing</creatorcontrib><creatorcontrib>Jia, Weidong</creatorcontrib><creatorcontrib>Zhao, Ming</creatorcontrib><creatorcontrib>Bi, Xinyu</creatorcontrib><creatorcontrib>Li, Gong</creatorcontrib><creatorcontrib>Bai, Xueli</creatorcontrib><creatorcontrib>Ji, Yuan</creatorcontrib><creatorcontrib>Xu, Li</creatorcontrib><creatorcontrib>Zhu, Xiao-Dong</creatorcontrib><creatorcontrib>Bai, Dousheng</creatorcontrib><creatorcontrib>Chen, Yajin</creatorcontrib><creatorcontrib>Chen, Yongjun</creatorcontrib><creatorcontrib>Dai, Chaoliu</creatorcontrib><creatorcontrib>Guo, Rongping</creatorcontrib><creatorcontrib>Guo, Wenzhi</creatorcontrib><creatorcontrib>Hao, Chunyi</creatorcontrib><creatorcontrib>Huang, Tao</creatorcontrib><creatorcontrib>Huang, Zhiyong</creatorcontrib><creatorcontrib>Li, Deyu</creatorcontrib><creatorcontrib>Li, Gang</creatorcontrib><creatorcontrib>Li, Tao</creatorcontrib><creatorcontrib>Li, Xiangcheng</creatorcontrib><creatorcontrib>Li, Guangming</creatorcontrib><creatorcontrib>Liang, Xiao</creatorcontrib><creatorcontrib>Liu, Jingfeng</creatorcontrib><creatorcontrib>Liu, Fubao</creatorcontrib><creatorcontrib>Lu, Shichun</creatorcontrib><creatorcontrib>Lu, Zheng</creatorcontrib><creatorcontrib>Lv, Weifu</creatorcontrib><creatorcontrib>Mao, Yilei</creatorcontrib><creatorcontrib>Shao, Guoliang</creatorcontrib><creatorcontrib>Shi, Yinghong</creatorcontrib><creatorcontrib>Song, Tianqiang</creatorcontrib><creatorcontrib>Tan, Guang</creatorcontrib><creatorcontrib>Tang, Yunqiang</creatorcontrib><creatorcontrib>Tao, Kaishan</creatorcontrib><creatorcontrib>Wan, Chidan</creatorcontrib><creatorcontrib>Wang, Guangyi</creatorcontrib><creatorcontrib>Wang, Lu</creatorcontrib><creatorcontrib>Wang, Shunxiang</creatorcontrib><creatorcontrib>Wen, Tianfu</creatorcontrib><creatorcontrib>Xing, Baocai</creatorcontrib><creatorcontrib>Xiang, Bangde</creatorcontrib><creatorcontrib>Yan, Sheng</creatorcontrib><creatorcontrib>Yang, Dinghua</creatorcontrib><creatorcontrib>Yin, Guowen</creatorcontrib><creatorcontrib>Yin, Tao</creatorcontrib><creatorcontrib>Yin, Zhenyu</creatorcontrib><creatorcontrib>Yu, Zhengping</creatorcontrib><creatorcontrib>Zhang, Bixiang</creatorcontrib><creatorcontrib>Zhang, Jialin</creatorcontrib><creatorcontrib>Zhang, Shuijun</creatorcontrib><creatorcontrib>Zhang, Ti</creatorcontrib><creatorcontrib>Zhang, Yamin</creatorcontrib><creatorcontrib>Zhang, Yubao</creatorcontrib><creatorcontrib>Zhang, Aibin</creatorcontrib><creatorcontrib>Zhao, Haitao</creatorcontrib><creatorcontrib>Zhou, Ledu</creatorcontrib><creatorcontrib>Zhang, Wu</creatorcontrib><creatorcontrib>Zhu, Zhenyu</creatorcontrib><creatorcontrib>Qin, Shukui</creatorcontrib><creatorcontrib>Shen, Feng</creatorcontrib><creatorcontrib>Cai, Xiujun</creatorcontrib><creatorcontrib>Teng, Gaojun</creatorcontrib><creatorcontrib>Cai, Jianqiang</creatorcontrib><creatorcontrib>Chen, Minshan</creatorcontrib><creatorcontrib>Li, Qiang</creatorcontrib><creatorcontrib>Liu, Lianxin</creatorcontrib><creatorcontrib>Wang, Weilin</creatorcontrib><creatorcontrib>Liang, Tingbo</creatorcontrib><creatorcontrib>Dong, Jiahong</creatorcontrib><creatorcontrib>Chen, Xiaoping</creatorcontrib><creatorcontrib>Wang, Xuehao</creatorcontrib><creatorcontrib>Zheng, Shusen</creatorcontrib><creatorcontrib>Fan, Jia</creatorcontrib><creatorcontrib>Alliance of Liver Cancer Conversion Therapy, Committee of Liver Cancer of the Chinese Anti-Cancer Association</creatorcontrib><title>Chinese expert consensus on conversion therapy for hepatocellular carcinoma (2021 edition)</title><title>Hepatobiliary surgery and nutrition</title><addtitle>Hepatobiliary Surg Nutr</addtitle><description>Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma (HCC) have resulted in improved response rates. This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection, a 'conversion therapy' strategy. However, conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed. Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice. Evidence review: Many research centers in China have accumulated significant experience implementing HCC conversion therapy. Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC; however, there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields. In order to summarize and learn from past experience and review current challenges, the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma (2021 Edition) was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice. Sixteen consensus statements on the implementation of conversion therapy for HCC were developed. The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.</description><subject>Review</subject><issn>2304-3881</issn><issn>2304-389X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpVkEtLAzEUhYMottTuXEuWCo7mNZpsBCm-oOBGQdyEPO44gWlmSKbF_nunVouu7rncc86FD6FjSi4YJfz6srY5FowWnMk9NGaciIJL9ba_05KO0DTnYAlXpSJEqkM04qW4EkzyMXqf1SFCBgyfHaQeuzZmiHmZcRs3ywpSDoPsa0imW-OqTbiGzvStg6ZZNiZhZ5ILsV0YfMoIoxh86IfI2RE6qEyTYfozJ-j1_u5l9ljMnx-eZrfzwnEq-uJaCMpK6yupSuG8syURxlNL5JUUVHEgwJRxlpWUVJWVglluqDfKMOe9p3yCbra93dIuwDuIfTKN7lJYmLTWrQn6_yWGWn-0K60I45JvCs63BS61OSeodllK9DdmvcE8SD1gHuwnf__tzL9Q-ReA3Xuw</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Sun, Hui-Chuan</creator><creator>Zhou, Jian</creator><creator>Wang, Zheng</creator><creator>Liu, 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Tianqiang</creatorcontrib><creatorcontrib>Tan, Guang</creatorcontrib><creatorcontrib>Tang, Yunqiang</creatorcontrib><creatorcontrib>Tao, Kaishan</creatorcontrib><creatorcontrib>Wan, Chidan</creatorcontrib><creatorcontrib>Wang, Guangyi</creatorcontrib><creatorcontrib>Wang, Lu</creatorcontrib><creatorcontrib>Wang, Shunxiang</creatorcontrib><creatorcontrib>Wen, Tianfu</creatorcontrib><creatorcontrib>Xing, Baocai</creatorcontrib><creatorcontrib>Xiang, Bangde</creatorcontrib><creatorcontrib>Yan, Sheng</creatorcontrib><creatorcontrib>Yang, Dinghua</creatorcontrib><creatorcontrib>Yin, Guowen</creatorcontrib><creatorcontrib>Yin, Tao</creatorcontrib><creatorcontrib>Yin, Zhenyu</creatorcontrib><creatorcontrib>Yu, Zhengping</creatorcontrib><creatorcontrib>Zhang, Bixiang</creatorcontrib><creatorcontrib>Zhang, Jialin</creatorcontrib><creatorcontrib>Zhang, Shuijun</creatorcontrib><creatorcontrib>Zhang, Ti</creatorcontrib><creatorcontrib>Zhang, Yamin</creatorcontrib><creatorcontrib>Zhang, Yubao</creatorcontrib><creatorcontrib>Zhang, Aibin</creatorcontrib><creatorcontrib>Zhao, Haitao</creatorcontrib><creatorcontrib>Zhou, Ledu</creatorcontrib><creatorcontrib>Zhang, Wu</creatorcontrib><creatorcontrib>Zhu, Zhenyu</creatorcontrib><creatorcontrib>Qin, Shukui</creatorcontrib><creatorcontrib>Shen, Feng</creatorcontrib><creatorcontrib>Cai, Xiujun</creatorcontrib><creatorcontrib>Teng, Gaojun</creatorcontrib><creatorcontrib>Cai, Jianqiang</creatorcontrib><creatorcontrib>Chen, Minshan</creatorcontrib><creatorcontrib>Li, Qiang</creatorcontrib><creatorcontrib>Liu, Lianxin</creatorcontrib><creatorcontrib>Wang, Weilin</creatorcontrib><creatorcontrib>Liang, Tingbo</creatorcontrib><creatorcontrib>Dong, Jiahong</creatorcontrib><creatorcontrib>Chen, Xiaoping</creatorcontrib><creatorcontrib>Wang, Xuehao</creatorcontrib><creatorcontrib>Zheng, Shusen</creatorcontrib><creatorcontrib>Fan, Jia</creatorcontrib><creatorcontrib>Alliance of Liver Cancer Conversion Therapy, Committee of Liver Cancer of the Chinese Anti-Cancer Association</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hepatobiliary surgery and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Hui-Chuan</au><au>Zhou, Jian</au><au>Wang, Zheng</au><au>Liu, Xiufeng</au><au>Xie, Qing</au><au>Jia, Weidong</au><au>Zhao, Ming</au><au>Bi, Xinyu</au><au>Li, Gong</au><au>Bai, Xueli</au><au>Ji, Yuan</au><au>Xu, Li</au><au>Zhu, Xiao-Dong</au><au>Bai, Dousheng</au><au>Chen, Yajin</au><au>Chen, Yongjun</au><au>Dai, Chaoliu</au><au>Guo, Rongping</au><au>Guo, Wenzhi</au><au>Hao, Chunyi</au><au>Huang, Tao</au><au>Huang, Zhiyong</au><au>Li, Deyu</au><au>Li, Gang</au><au>Li, Tao</au><au>Li, Xiangcheng</au><au>Li, Guangming</au><au>Liang, Xiao</au><au>Liu, Jingfeng</au><au>Liu, Fubao</au><au>Lu, Shichun</au><au>Lu, Zheng</au><au>Lv, Weifu</au><au>Mao, Yilei</au><au>Shao, Guoliang</au><au>Shi, Yinghong</au><au>Song, Tianqiang</au><au>Tan, Guang</au><au>Tang, Yunqiang</au><au>Tao, Kaishan</au><au>Wan, Chidan</au><au>Wang, Guangyi</au><au>Wang, Lu</au><au>Wang, Shunxiang</au><au>Wen, Tianfu</au><au>Xing, Baocai</au><au>Xiang, Bangde</au><au>Yan, Sheng</au><au>Yang, Dinghua</au><au>Yin, Guowen</au><au>Yin, Tao</au><au>Yin, Zhenyu</au><au>Yu, Zhengping</au><au>Zhang, Bixiang</au><au>Zhang, Jialin</au><au>Zhang, Shuijun</au><au>Zhang, Ti</au><au>Zhang, Yamin</au><au>Zhang, Yubao</au><au>Zhang, Aibin</au><au>Zhao, Haitao</au><au>Zhou, Ledu</au><au>Zhang, Wu</au><au>Zhu, Zhenyu</au><au>Qin, Shukui</au><au>Shen, Feng</au><au>Cai, Xiujun</au><au>Teng, Gaojun</au><au>Cai, Jianqiang</au><au>Chen, Minshan</au><au>Li, Qiang</au><au>Liu, Lianxin</au><au>Wang, Weilin</au><au>Liang, Tingbo</au><au>Dong, Jiahong</au><au>Chen, Xiaoping</au><au>Wang, Xuehao</au><au>Zheng, Shusen</au><au>Fan, Jia</au><aucorp>Alliance of Liver Cancer Conversion Therapy, Committee of Liver Cancer of the Chinese Anti-Cancer Association</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chinese expert consensus on conversion therapy for hepatocellular carcinoma (2021 edition)</atitle><jtitle>Hepatobiliary surgery and nutrition</jtitle><addtitle>Hepatobiliary Surg Nutr</addtitle><date>2022-04</date><risdate>2022</risdate><volume>11</volume><issue>2</issue><spage>227</spage><epage>252</epage><pages>227-252</pages><issn>2304-3881</issn><eissn>2304-389X</eissn><abstract>Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma (HCC) have resulted in improved response rates. This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection, a 'conversion therapy' strategy. However, conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed. Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice. Evidence review: Many research centers in China have accumulated significant experience implementing HCC conversion therapy. Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC; however, there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields. In order to summarize and learn from past experience and review current challenges, the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma (2021 Edition) was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice. Sixteen consensus statements on the implementation of conversion therapy for HCC were developed. The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.</abstract><cop>China (Republic : 1949- )</cop><pub>AME Publishing Company</pub><pmid>35464283</pmid><doi>10.21037/hbsn-21-328</doi><tpages>26</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2304-3881 |
| ispartof | Hepatobiliary surgery and nutrition, 2022-04, Vol.11 (2), p.227-252 |
| issn | 2304-3881 2304-389X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9023831 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Review |
| title | Chinese expert consensus on conversion therapy for hepatocellular carcinoma (2021 edition) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T15%3A09%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chinese%20expert%20consensus%20on%20conversion%20therapy%20for%20hepatocellular%20carcinoma%20(2021%20edition)&rft.jtitle=Hepatobiliary%20surgery%20and%20nutrition&rft.au=Sun,%20Hui-Chuan&rft.aucorp=Alliance%20of%20Liver%20Cancer%20Conversion%20Therapy,%20Committee%20of%20Liver%20Cancer%20of%20the%20Chinese%20Anti-Cancer%20Association&rft.date=2022-04&rft.volume=11&rft.issue=2&rft.spage=227&rft.epage=252&rft.pages=227-252&rft.issn=2304-3881&rft.eissn=2304-389X&rft_id=info:doi/10.21037/hbsn-21-328&rft_dat=%3Cpubmed_cross%3E35464283%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/35464283&rfr_iscdi=true |