Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids

Human gastric development has not been well studied. The generation of human pluripotent stem cell-derived gastric organoids (hGOs) comprising gastric marker-expressing epithelium without an apparent smooth muscle (SM) structure has been reported. We modified previously reported protocols to generat...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Stem cell reports 2022-04, Vol.17 (4), p.820-834
Hauptverfasser:	Uehara, Keiichiro, Koyanagi-Aoi, Michiyo, Koide, Takahiro, Itoh, Tomoo, Aoi, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	gastric organoid Hedgehog Proteins Hedgehog signal hiPSC Humans Induced Pluripotent Stem Cells mechanical property Mucous Membrane muscularis mucosa Organoids signal Stomach TGF-β Transforming Growth Factor beta
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!