Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends

Abstract Homologous recombination-deficient cancers rely on DNA polymerase Theta (Polθ)-Mediated End Joining (TMEJ), an alternative double-strand break repair pathway. Polθ is the only vertebrate polymerase that encodes an N-terminal superfamily 2 (SF2) helicase domain, but the role of this helicase...

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Veröffentlicht in:	Nucleic acids research 2022-04, Vol.50 (7), p.3911-3921
Hauptverfasser:	Schaub, Jeffrey M, Soniat, Michael M, Finkelstein, Ilya J
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry DNA Breaks, Double-Stranded DNA End-Joining Repair DNA Helicases - genetics DNA, Single-Stranded - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Genome Integrity, Repair and Replication Protein A - genetics Replication Protein A - metabolism
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