Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/β-Catenin Signaling Pathway in Psoriasis Mouse Model
Background. Psoriasis is a common chronic inflammatory skin disease with multifactor etiology, characterized by abnormal proliferation and differentiation of keratinocytes. Huang-Lian Jie-Du decoction (HLJDD) is a traditional Chinese medicine prescription with good clinical curative effect on psoria...
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| creator | Yang, Xuesong Luo, Guangyun Fu, Lan Huang, Hong Wang, Lifen Yin, Lihua Zhang, Xuelian Wang, Tingting Ma, Xuan Feng, Tianyu Ye, Jianzhou |
| description | Background. Psoriasis is a common chronic inflammatory skin disease with multifactor etiology, characterized by abnormal proliferation and differentiation of keratinocytes. Huang-Lian Jie-Du decoction (HLJDD) is a traditional Chinese medicine prescription with good clinical curative effect on psoriasis. However, its therapeutic mechanisms are still unclear. Methods. The psoriasis model of SKH-1 nude mice was established by imiquimod-induced and HLJDD gavage was given. Hematoxylin and eosin staining were used to evaluate pathological morphologies, and immunohistochemistry was used to detect the expressions of Wnt1, β-catenin, and c-Myc in psoriasis mice. Western blot was used to examine the expressions of Frizzled-2, LRP5/6, GSK-3β, APC, Axin2, TCF4, LEF1, cyclin D1, TBX3, EPHB2, and NOTUM enzyme. Results. In this study, HLJDD reduced skin erythema and lesions, decreased the thickness of epidermal and downregulated the expressions of Wnt1, β-catenin, and c-Myc. Western blot results showed that HLJDD reduced the expressions of Wnt receptors Frizzled-2 and LRP5/6, and Wnt downstream target genes TCF4, LEF1, cyclin D1, TBX3, and EPHB2, while upregulated destruction complex proteins GSK-3β, APC, and Axin2. Conclusions. HLJDD can effectively treat psoriasis and inhibit the Wnt/β-catenin signaling pathway at multiple stages. |
| doi_str_mv | 10.1155/2022/3193572 |
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Psoriasis is a common chronic inflammatory skin disease with multifactor etiology, characterized by abnormal proliferation and differentiation of keratinocytes. Huang-Lian Jie-Du decoction (HLJDD) is a traditional Chinese medicine prescription with good clinical curative effect on psoriasis. However, its therapeutic mechanisms are still unclear. Methods. The psoriasis model of SKH-1 nude mice was established by imiquimod-induced and HLJDD gavage was given. Hematoxylin and eosin staining were used to evaluate pathological morphologies, and immunohistochemistry was used to detect the expressions of Wnt1, β-catenin, and c-Myc in psoriasis mice. Western blot was used to examine the expressions of Frizzled-2, LRP5/6, GSK-3β, APC, Axin2, TCF4, LEF1, cyclin D1, TBX3, EPHB2, and NOTUM enzyme. Results. In this study, HLJDD reduced skin erythema and lesions, decreased the thickness of epidermal and downregulated the expressions of Wnt1, β-catenin, and c-Myc. Western blot results showed that HLJDD reduced the expressions of Wnt receptors Frizzled-2 and LRP5/6, and Wnt downstream target genes TCF4, LEF1, cyclin D1, TBX3, and EPHB2, while upregulated destruction complex proteins GSK-3β, APC, and Axin2. Conclusions. HLJDD can effectively treat psoriasis and inhibit the Wnt/β-catenin signaling pathway at multiple stages.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2022/3193572</identifier><identifier>PMID: 35463060</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Antibodies ; Antiviral drugs ; Apoptosis ; c-Myc protein ; Cell growth ; Chinese medicine ; Cyclin D1 ; Erythema ; Etiology ; Experiments ; Frizzled protein ; Gene expression ; Imiquimod ; Immunohistochemistry ; Keratinocytes ; Laboratory animals ; LRP5 protein ; Myc protein ; Pharmaceuticals ; Proteins ; Psoriasis ; Signal transduction ; Skin ; Skin diseases ; Traditional Chinese medicine ; Wnt protein ; β-Catenin</subject><ispartof>Evidence-based complementary and alternative medicine, 2022-04, Vol.2022, p.3193572-11</ispartof><rights>Copyright © 2022 Xuesong Yang et al.</rights><rights>Copyright © 2022 Xuesong Yang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Xuesong Yang et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-788f17cf6ea80103b0506c40adeffd662f934fd62cc56409f80c04acb84679553</citedby><cites>FETCH-LOGICAL-c378t-788f17cf6ea80103b0506c40adeffd662f934fd62cc56409f80c04acb84679553</cites><orcidid>0000-0003-1954-238X ; 0000-0003-3533-5823 ; 0000-0002-8824-0601 ; 0000-0003-3008-3807 ; 0000-0002-0164-2510 ; 0000-0002-2081-9297 ; 0000-0003-0781-3824 ; 0000-0003-1548-4768 ; 0000-0002-3515-1285 ; 0000-0002-9205-4609 ; 0000-0001-5027-8092</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023143/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023143/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35463060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cohen, Guy</contributor><contributor>Guy Cohen</contributor><creatorcontrib>Yang, Xuesong</creatorcontrib><creatorcontrib>Luo, Guangyun</creatorcontrib><creatorcontrib>Fu, Lan</creatorcontrib><creatorcontrib>Huang, Hong</creatorcontrib><creatorcontrib>Wang, Lifen</creatorcontrib><creatorcontrib>Yin, Lihua</creatorcontrib><creatorcontrib>Zhang, Xuelian</creatorcontrib><creatorcontrib>Wang, Tingting</creatorcontrib><creatorcontrib>Ma, Xuan</creatorcontrib><creatorcontrib>Feng, Tianyu</creatorcontrib><creatorcontrib>Ye, Jianzhou</creatorcontrib><title>Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/β-Catenin Signaling Pathway in Psoriasis Mouse Model</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Background. Psoriasis is a common chronic inflammatory skin disease with multifactor etiology, characterized by abnormal proliferation and differentiation of keratinocytes. Huang-Lian Jie-Du decoction (HLJDD) is a traditional Chinese medicine prescription with good clinical curative effect on psoriasis. However, its therapeutic mechanisms are still unclear. Methods. The psoriasis model of SKH-1 nude mice was established by imiquimod-induced and HLJDD gavage was given. Hematoxylin and eosin staining were used to evaluate pathological morphologies, and immunohistochemistry was used to detect the expressions of Wnt1, β-catenin, and c-Myc in psoriasis mice. Western blot was used to examine the expressions of Frizzled-2, LRP5/6, GSK-3β, APC, Axin2, TCF4, LEF1, cyclin D1, TBX3, EPHB2, and NOTUM enzyme. Results. In this study, HLJDD reduced skin erythema and lesions, decreased the thickness of epidermal and downregulated the expressions of Wnt1, β-catenin, and c-Myc. Western blot results showed that HLJDD reduced the expressions of Wnt receptors Frizzled-2 and LRP5/6, and Wnt downstream target genes TCF4, LEF1, cyclin D1, TBX3, and EPHB2, while upregulated destruction complex proteins GSK-3β, APC, and Axin2. Conclusions. HLJDD can effectively treat psoriasis and inhibit the Wnt/β-catenin signaling pathway at multiple stages.</description><subject>Antibodies</subject><subject>Antiviral drugs</subject><subject>Apoptosis</subject><subject>c-Myc protein</subject><subject>Cell growth</subject><subject>Chinese medicine</subject><subject>Cyclin D1</subject><subject>Erythema</subject><subject>Etiology</subject><subject>Experiments</subject><subject>Frizzled protein</subject><subject>Gene expression</subject><subject>Imiquimod</subject><subject>Immunohistochemistry</subject><subject>Keratinocytes</subject><subject>Laboratory animals</subject><subject>LRP5 protein</subject><subject>Myc protein</subject><subject>Pharmaceuticals</subject><subject>Proteins</subject><subject>Psoriasis</subject><subject>Signal transduction</subject><subject>Skin</subject><subject>Skin diseases</subject><subject>Traditional Chinese medicine</subject><subject>Wnt protein</subject><subject>β-Catenin</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kV1rFDEUhgex2Fq981oC3gg63XwncyPIVvvBFgsqehfOZjK7KbNJTWZaCv4qf4i_qWl3u6gXQjg5nDy8nDdvVb0g-IAQISYUUzphpGFC0UfVHlGc1Jxq_Xjbq--71dOcLzCmjVLqSbXLBJcMS7xX_TwJg0tXLgw-BnTm7BKCzysUO3Q8BljUMw8BnXpXH47o0Nlo78FyphBi8BZ69C0Mk9-_6ikMLviAPvtFgN6HBTqHYXkNN6gMz3NMHrLP6CyO2ZXauv5ZtdNBn93zzb1fff344cv0uJ59OjqZvp_Vlik91ErrjijbSQcaE8zmWGBpOYbWdV0rJe0axktDrRWS46bT2GIOdq65VI0QbL96t9a9HOcr19riNkFvLpNfQboxEbz5-yX4pVnEK9NgyghnReD1RiDFH6PLg1n5bF3fQ3DFjqFSCIIJp7igr_5BL-KYyofcU0w3ikpaqLdryqaYc3LddhmCzV2s5i5Ws4m14C__NLCFH3IswJs1sPShhWv_f7lbr6erXA</recordid><startdate>20220414</startdate><enddate>20220414</enddate><creator>Yang, 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Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/β-Catenin Signaling Pathway in Psoriasis Mouse Model</title><author>Yang, Xuesong ; Luo, Guangyun ; Fu, Lan ; Huang, Hong ; Wang, Lifen ; Yin, Lihua ; Zhang, Xuelian ; Wang, Tingting ; Ma, Xuan ; Feng, Tianyu ; Ye, Jianzhou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-788f17cf6ea80103b0506c40adeffd662f934fd62cc56409f80c04acb84679553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antibodies</topic><topic>Antiviral drugs</topic><topic>Apoptosis</topic><topic>c-Myc protein</topic><topic>Cell growth</topic><topic>Chinese medicine</topic><topic>Cyclin D1</topic><topic>Erythema</topic><topic>Etiology</topic><topic>Experiments</topic><topic>Frizzled protein</topic><topic>Gene expression</topic><topic>Imiquimod</topic><topic>Immunohistochemistry</topic><topic>Keratinocytes</topic><topic>Laboratory animals</topic><topic>LRP5 protein</topic><topic>Myc protein</topic><topic>Pharmaceuticals</topic><topic>Proteins</topic><topic>Psoriasis</topic><topic>Signal transduction</topic><topic>Skin</topic><topic>Skin diseases</topic><topic>Traditional Chinese medicine</topic><topic>Wnt protein</topic><topic>β-Catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Xuesong</creatorcontrib><creatorcontrib>Luo, Guangyun</creatorcontrib><creatorcontrib>Fu, Lan</creatorcontrib><creatorcontrib>Huang, Hong</creatorcontrib><creatorcontrib>Wang, Lifen</creatorcontrib><creatorcontrib>Yin, Lihua</creatorcontrib><creatorcontrib>Zhang, Xuelian</creatorcontrib><creatorcontrib>Wang, Tingting</creatorcontrib><creatorcontrib>Ma, Xuan</creatorcontrib><creatorcontrib>Feng, Tianyu</creatorcontrib><creatorcontrib>Ye, Jianzhou</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription 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Psoriasis Mouse Model</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2022-04-14</date><risdate>2022</risdate><volume>2022</volume><spage>3193572</spage><epage>11</epage><pages>3193572-11</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Background. Psoriasis is a common chronic inflammatory skin disease with multifactor etiology, characterized by abnormal proliferation and differentiation of keratinocytes. Huang-Lian Jie-Du decoction (HLJDD) is a traditional Chinese medicine prescription with good clinical curative effect on psoriasis. However, its therapeutic mechanisms are still unclear. Methods. The psoriasis model of SKH-1 nude mice was established by imiquimod-induced and HLJDD gavage was given. Hematoxylin and eosin staining were used to evaluate pathological morphologies, and immunohistochemistry was used to detect the expressions of Wnt1, β-catenin, and c-Myc in psoriasis mice. Western blot was used to examine the expressions of Frizzled-2, LRP5/6, GSK-3β, APC, Axin2, TCF4, LEF1, cyclin D1, TBX3, EPHB2, and NOTUM enzyme. Results. In this study, HLJDD reduced skin erythema and lesions, decreased the thickness of epidermal and downregulated the expressions of Wnt1, β-catenin, and c-Myc. Western blot results showed that HLJDD reduced the expressions of Wnt receptors Frizzled-2 and LRP5/6, and Wnt downstream target genes TCF4, LEF1, cyclin D1, TBX3, and EPHB2, while upregulated destruction complex proteins GSK-3β, APC, and Axin2. Conclusions. HLJDD can effectively treat psoriasis and inhibit the Wnt/β-catenin signaling pathway at multiple stages.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35463060</pmid><doi>10.1155/2022/3193572</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-1954-238X</orcidid><orcidid>https://orcid.org/0000-0003-3533-5823</orcidid><orcidid>https://orcid.org/0000-0002-8824-0601</orcidid><orcidid>https://orcid.org/0000-0003-3008-3807</orcidid><orcidid>https://orcid.org/0000-0002-0164-2510</orcidid><orcidid>https://orcid.org/0000-0002-2081-9297</orcidid><orcidid>https://orcid.org/0000-0003-0781-3824</orcidid><orcidid>https://orcid.org/0000-0003-1548-4768</orcidid><orcidid>https://orcid.org/0000-0002-3515-1285</orcidid><orcidid>https://orcid.org/0000-0002-9205-4609</orcidid><orcidid>https://orcid.org/0000-0001-5027-8092</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies Antiviral drugs Apoptosis c-Myc protein Cell growth Chinese medicine Cyclin D1 Erythema Etiology Experiments Frizzled protein Gene expression Imiquimod Immunohistochemistry Keratinocytes Laboratory animals LRP5 protein Myc protein Pharmaceuticals Proteins Psoriasis Signal transduction Skin Skin diseases Traditional Chinese medicine Wnt protein β-Catenin |
| title | Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/β-Catenin Signaling Pathway in Psoriasis Mouse Model |
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