Analysis of the miRNA-mRNA Regulatory Network Reveals the Biomarker Genes in the Progression of Myocardial Ischemic Reperfusion

Objective. Cardiac injury induced by myocardial ischemic reperfusion (MI/R) is still an intractable question in clinical, and it has been confirmed as a major reason for the development of cardiovascular disease. Bioinformatics analysis has been widely used for revealing the pathogenic mechanism of...

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Veröffentlicht in:	Journal of healthcare engineering 2022-04, Vol.2022, p.2045619-7
Hauptverfasser:	Li, Nini, Chen, Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans MicroRNAs - genetics MicroRNAs - metabolism Myocardial Reperfusion Injury - genetics Phosphatidylinositol 3-Kinases - metabolism RNA, Messenger - genetics
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Zusammenfassung:	Objective. Cardiac injury induced by myocardial ischemic reperfusion (MI/R) is still an intractable question in clinical, and it has been confirmed as a major reason for the development of cardiovascular disease. Bioinformatics analysis has been widely used for revealing the pathogenic mechanism of diseases. This study attempted to identify the biomarkers and reveal the regulation mechanism of MI/R injury via bioinformatics analysis. Methods. The GSE67308 and GSE74951 were obtained from the GEO database. The datasets were analyzed with GEO2R tool, and the genes with \|logFC\| > 2 and p value
ISSN:	2040-2295 2040-2309
DOI:	10.1155/2022/2045619