Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case

Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case

Coronavirus disease 2019 (COVID-19) -related intracranial hemorrhage (ICH) is believed to be associated with at least one known risk factor for ICH, such as hypertension, hyperlipidemia, diabetes mellitus, severe pneumonia, or anticoagulation therapy. However, in this study, we report a case of ICH...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:NMC Case Report Journal 2022/12/31, Vol.9, pp.63-67
Hauptverfasser: SHINODA, Narihide, TAMURA, Shogo, MORI, Masafumi, NAKAMURA, Mitsugu, KOROSUE, Kazuyoshi, KOSE, Shigeru
Format: Artikel
Sprache:eng
Schlagworte:
angiotensin-converting enzyme 2 (ACE2)
Case Report
Coronavirus disease 2019 (COVID-19)
COVID-19-related ICH
vitamin K-dependent coagulation factors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 67
container_issue
container_start_page 63
container_title NMC Case Report Journal
container_volume 9
creator SHINODA, Narihide
TAMURA, Shogo
MORI, Masafumi
NAKAMURA, Mitsugu
KOROSUE, Kazuyoshi
KOSE, Shigeru
description Coronavirus disease 2019 (COVID-19) -related intracranial hemorrhage (ICH) is believed to be associated with at least one known risk factor for ICH, such as hypertension, hyperlipidemia, diabetes mellitus, severe pneumonia, or anticoagulation therapy. However, in this study, we report a case of ICH in a 14-year-old boy with mild COVID-19 infection without pneumonia who had no such risk factors. The only abnormal laboratory finding was temporary depletion of vitamin K-dependent coagulation factors. This case indicates that COVID-19 infection may cause simultaneous asymptomatic intracranial microhemorrhages and temporary depletion of vitamin K-dependent coagulation factors. This temporary depletion might transform the intracranial microhemorrhages into symptomatic ICH.
doi_str_mv 10.2176/jns-nmc.2021-0295
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9020866</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2658644441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4525-efc01e271c8b4edd6ce93f3bd6b3e7c3e693d51617126e112d2dd1285f45c513</originalsourceid><addsrcrecordid>eNpVkc1q3DAUhU1paUKSB-imaNmNU_1Yst1FIcw0zZCUdDFkKzTS9YwGW3IlOdB36cNWZlKTCoQu3HPP0eUrig8EX1NSi89HF0s36GuKKSkxbfmb4pySpikrSsXbV_VZcRXjEWNMmrpuMXlfnDFetYwzfl78-ekTuGRVj36APihn4xCR79Dq8WmzLklbBuhVAoM2LgWlQ1Zk7R0MPoSD2gNaT4CSR1sYRh9U-I3WMPaQrHezzZNNarAO3ZcGRnAmZ6GVV_spm86SW6WTD_ELunFo0_dTzCHJPgNaqQiXxbtO9RGuXt6LYnv7bbu6Kx8ev29WNw-lrjjlJXQaE6A10c2uAmOEhpZ1bGfEjkGtGYiWGU4EqQkVQAg11BhCG95VXHPCLoqvJ9tx2g1gNMyb9nIMdsj7SK-s_L_j7EHu_bNsMcWNENng04tB8L8miEkONmroe-XAT1FSwRtR5TNnkZNUBx9jgG6JIVjOXGXmKjNXOXOVM9c88_H1_5aJfxSzYH0SHGPKSBaBCsnqHmY7HY6ylTjfxXdpZ-xBgmN_Acxnu5k</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2658644441</pqid></control><display><type>article</type><title>Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case</title><source>J-STAGE Free</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>SHINODA, Narihide ; TAMURA, Shogo ; MORI, Masafumi ; NAKAMURA, Mitsugu ; KOROSUE, Kazuyoshi ; KOSE, Shigeru</creator><creatorcontrib>SHINODA, Narihide ; TAMURA, Shogo ; MORI, Masafumi ; NAKAMURA, Mitsugu ; KOROSUE, Kazuyoshi ; KOSE, Shigeru</creatorcontrib><description>Coronavirus disease 2019 (COVID-19) -related intracranial hemorrhage (ICH) is believed to be associated with at least one known risk factor for ICH, such as hypertension, hyperlipidemia, diabetes mellitus, severe pneumonia, or anticoagulation therapy. However, in this study, we report a case of ICH in a 14-year-old boy with mild COVID-19 infection without pneumonia who had no such risk factors. The only abnormal laboratory finding was temporary depletion of vitamin K-dependent coagulation factors. This case indicates that COVID-19 infection may cause simultaneous asymptomatic intracranial microhemorrhages and temporary depletion of vitamin K-dependent coagulation factors. This temporary depletion might transform the intracranial microhemorrhages into symptomatic ICH.</description><identifier>ISSN: 2188-4226</identifier><identifier>EISSN: 2188-4226</identifier><identifier>DOI: 10.2176/jns-nmc.2021-0295</identifier><identifier>PMID: 35493535</identifier><language>eng</language><publisher>Japan: The Japan Neurosurgical Society</publisher><subject>angiotensin-converting enzyme 2 (ACE2) ; Case Report ; Coronavirus disease 2019 (COVID-19) ; COVID-19-related ICH ; vitamin K-dependent coagulation factors</subject><ispartof>NMC Case Report Journal, 2022/12/31, Vol.9, pp.63-67</ispartof><rights>2022 The Japan Neurosurgical Society</rights><rights>2022 The Japan Neurosurgical Society.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4525-efc01e271c8b4edd6ce93f3bd6b3e7c3e693d51617126e112d2dd1285f45c513</citedby><cites>FETCH-LOGICAL-c4525-efc01e271c8b4edd6ce93f3bd6b3e7c3e693d51617126e112d2dd1285f45c513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020866/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020866/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,1879,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35493535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHINODA, Narihide</creatorcontrib><creatorcontrib>TAMURA, Shogo</creatorcontrib><creatorcontrib>MORI, Masafumi</creatorcontrib><creatorcontrib>NAKAMURA, Mitsugu</creatorcontrib><creatorcontrib>KOROSUE, Kazuyoshi</creatorcontrib><creatorcontrib>KOSE, Shigeru</creatorcontrib><title>Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case</title><title>NMC Case Report Journal</title><addtitle>NMC Case Rep J</addtitle><description>Coronavirus disease 2019 (COVID-19) -related intracranial hemorrhage (ICH) is believed to be associated with at least one known risk factor for ICH, such as hypertension, hyperlipidemia, diabetes mellitus, severe pneumonia, or anticoagulation therapy. However, in this study, we report a case of ICH in a 14-year-old boy with mild COVID-19 infection without pneumonia who had no such risk factors. The only abnormal laboratory finding was temporary depletion of vitamin K-dependent coagulation factors. This case indicates that COVID-19 infection may cause simultaneous asymptomatic intracranial microhemorrhages and temporary depletion of vitamin K-dependent coagulation factors. This temporary depletion might transform the intracranial microhemorrhages into symptomatic ICH.</description><subject>angiotensin-converting enzyme 2 (ACE2)</subject><subject>Case Report</subject><subject>Coronavirus disease 2019 (COVID-19)</subject><subject>COVID-19-related ICH</subject><subject>vitamin K-dependent coagulation factors</subject><issn>2188-4226</issn><issn>2188-4226</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpVkc1q3DAUhU1paUKSB-imaNmNU_1Yst1FIcw0zZCUdDFkKzTS9YwGW3IlOdB36cNWZlKTCoQu3HPP0eUrig8EX1NSi89HF0s36GuKKSkxbfmb4pySpikrSsXbV_VZcRXjEWNMmrpuMXlfnDFetYwzfl78-ekTuGRVj36APihn4xCR79Dq8WmzLklbBuhVAoM2LgWlQ1Zk7R0MPoSD2gNaT4CSR1sYRh9U-I3WMPaQrHezzZNNarAO3ZcGRnAmZ6GVV_spm86SW6WTD_ELunFo0_dTzCHJPgNaqQiXxbtO9RGuXt6LYnv7bbu6Kx8ev29WNw-lrjjlJXQaE6A10c2uAmOEhpZ1bGfEjkGtGYiWGU4EqQkVQAg11BhCG95VXHPCLoqvJ9tx2g1gNMyb9nIMdsj7SK-s_L_j7EHu_bNsMcWNENng04tB8L8miEkONmroe-XAT1FSwRtR5TNnkZNUBx9jgG6JIVjOXGXmKjNXOXOVM9c88_H1_5aJfxSzYH0SHGPKSBaBCsnqHmY7HY6ylTjfxXdpZ-xBgmN_Acxnu5k</recordid><startdate>20221231</startdate><enddate>20221231</enddate><creator>SHINODA, Narihide</creator><creator>TAMURA, Shogo</creator><creator>MORI, Masafumi</creator><creator>NAKAMURA, Mitsugu</creator><creator>KOROSUE, Kazuyoshi</creator><creator>KOSE, Shigeru</creator><general>The Japan Neurosurgical Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20221231</creationdate><title>Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case</title><author>SHINODA, Narihide ; TAMURA, Shogo ; MORI, Masafumi ; NAKAMURA, Mitsugu ; KOROSUE, Kazuyoshi ; KOSE, Shigeru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4525-efc01e271c8b4edd6ce93f3bd6b3e7c3e693d51617126e112d2dd1285f45c513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>angiotensin-converting enzyme 2 (ACE2)</topic><topic>Case Report</topic><topic>Coronavirus disease 2019 (COVID-19)</topic><topic>COVID-19-related ICH</topic><topic>vitamin K-dependent coagulation factors</topic><toplevel>online_resources</toplevel><creatorcontrib>SHINODA, Narihide</creatorcontrib><creatorcontrib>TAMURA, Shogo</creatorcontrib><creatorcontrib>MORI, Masafumi</creatorcontrib><creatorcontrib>NAKAMURA, Mitsugu</creatorcontrib><creatorcontrib>KOROSUE, Kazuyoshi</creatorcontrib><creatorcontrib>KOSE, Shigeru</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>NMC Case Report Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHINODA, Narihide</au><au>TAMURA, Shogo</au><au>MORI, Masafumi</au><au>NAKAMURA, Mitsugu</au><au>KOROSUE, Kazuyoshi</au><au>KOSE, Shigeru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case</atitle><jtitle>NMC Case Report Journal</jtitle><addtitle>NMC Case Rep J</addtitle><date>2022-12-31</date><risdate>2022</risdate><volume>9</volume><spage>63</spage><epage>67</epage><pages>63-67</pages><artnum>2021-0295</artnum><issn>2188-4226</issn><eissn>2188-4226</eissn><abstract>Coronavirus disease 2019 (COVID-19) -related intracranial hemorrhage (ICH) is believed to be associated with at least one known risk factor for ICH, such as hypertension, hyperlipidemia, diabetes mellitus, severe pneumonia, or anticoagulation therapy. However, in this study, we report a case of ICH in a 14-year-old boy with mild COVID-19 infection without pneumonia who had no such risk factors. The only abnormal laboratory finding was temporary depletion of vitamin K-dependent coagulation factors. This case indicates that COVID-19 infection may cause simultaneous asymptomatic intracranial microhemorrhages and temporary depletion of vitamin K-dependent coagulation factors. This temporary depletion might transform the intracranial microhemorrhages into symptomatic ICH.</abstract><cop>Japan</cop><pub>The Japan Neurosurgical Society</pub><pmid>35493535</pmid><doi>10.2176/jns-nmc.2021-0295</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2188-4226
ispartof NMC Case Report Journal, 2022/12/31, Vol.9, pp.63-67
issn 2188-4226
2188-4226
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9020866
source J-STAGE Free; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central
subjects angiotensin-converting enzyme 2 (ACE2)
Case Report
Coronavirus disease 2019 (COVID-19)
COVID-19-related ICH
vitamin K-dependent coagulation factors
title Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T19%3A37%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Potential%20Mechanisms%20of%20COVID-19-related%20Intracranial%20Hemorrhage%20Due%20to%20Temporary%20Depletion%20of%20Vitamin%20K-dependent%20Coagulation%20Factors:%20An%20Illustrative%20Case&rft.jtitle=NMC%20Case%20Report%20Journal&rft.au=SHINODA,%20Narihide&rft.date=2022-12-31&rft.volume=9&rft.spage=63&rft.epage=67&rft.pages=63-67&rft.artnum=2021-0295&rft.issn=2188-4226&rft.eissn=2188-4226&rft_id=info:doi/10.2176/jns-nmc.2021-0295&rft_dat=%3Cproquest_pubme%3E2658644441%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2658644441&rft_id=info:pmid/35493535&rfr_iscdi=true