The procoagulant status. Hypercoagulability as a risk factor of primary and secondary infertility
Thrombophilia is a disorder that makes patients susceptible to intravascular thrombosis that may increase the risk of developing a pregnancy on a known pathology. The female patient diagnosed with hypoplastic uterus and hereditary thrombophilia had a favorable evolution under properly administered a...
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| Veröffentlicht in: | Romanian journal of morphology and embryology 2021-07, Vol.62 (3), p.829-834 |
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| container_title | Romanian journal of morphology and embryology |
| container_volume | 62 |
| creator | Neamţu, Simona Daniela Stanca, Liliana Siminel, Mirela Anişoara Neamţu, Adela Valeria Gluhovschi, Adrian Mateescu, Garofiţa Olivia Dijmărescu, Anda Lorena Săndulescu, Maria Sidonia Istrate-Ofiţeru, Anca Maria Trăistaru, Magdalena Rodica |
| description | Thrombophilia is a disorder that makes patients susceptible to intravascular thrombosis that may increase the risk of developing a pregnancy on a known pathology. The female patient diagnosed with hypoplastic uterus and hereditary thrombophilia had a favorable evolution under properly administered anticoagulant treatment. The homozygous status for the C677T mutation may lead to an increase in plasma homocysteine levels, especially in pregnant women, being an associated risk factor for thrombosis. The risk of developing intravascular thrombosis requires primary prevention measures by adding D-dimers in the early diagnostic algorithm, being the most accurate marker of hypercoagulability and endogenous fibrinolysis. The corroboration of the hypercoagulability status with the results of genotyping, the frequencies of the minor/major alleles studied, single mononucleotide polymorphisms (SNPs) and the establishment of preventive therapy, aims to prevent intravascular thrombosis and thromboembolic phenomena. |
| doi_str_mv | 10.47162/RJME.62.3.21 |
| format | Article |
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Hypercoagulability as a risk factor of primary and secondary infertility</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Neamţu, Simona Daniela ; Stanca, Liliana ; Siminel, Mirela Anişoara ; Neamţu, Adela Valeria ; Gluhovschi, Adrian ; Mateescu, Garofiţa Olivia ; Dijmărescu, Anda Lorena ; Săndulescu, Maria Sidonia ; Istrate-Ofiţeru, Anca Maria ; Trăistaru, Magdalena Rodica</creator><creatorcontrib>Neamţu, Simona Daniela ; Stanca, Liliana ; Siminel, Mirela Anişoara ; Neamţu, Adela Valeria ; Gluhovschi, Adrian ; Mateescu, Garofiţa Olivia ; Dijmărescu, Anda Lorena ; Săndulescu, Maria Sidonia ; Istrate-Ofiţeru, Anca Maria ; Trăistaru, Magdalena Rodica ; Department of Neonatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania ; Department of Legal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania ; Student, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania ; Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania ; Department of Medical Rehabilitation, University of Medicine and Pharmacy of Craiova, Romania ; Department of Hematology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania ; Department of Obstetrics and Gynecology, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania ; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><description>Thrombophilia is a disorder that makes patients susceptible to intravascular thrombosis that may increase the risk of developing a pregnancy on a known pathology. The female patient diagnosed with hypoplastic uterus and hereditary thrombophilia had a favorable evolution under properly administered anticoagulant treatment. The homozygous status for the C677T mutation may lead to an increase in plasma homocysteine levels, especially in pregnant women, being an associated risk factor for thrombosis. The risk of developing intravascular thrombosis requires primary prevention measures by adding D-dimers in the early diagnostic algorithm, being the most accurate marker of hypercoagulability and endogenous fibrinolysis. The corroboration of the hypercoagulability status with the results of genotyping, the frequencies of the minor/major alleles studied, single mononucleotide polymorphisms (SNPs) and the establishment of preventive therapy, aims to prevent intravascular thrombosis and thromboembolic phenomena.</description><identifier>ISSN: 1220-0522</identifier><identifier>EISSN: 2066-8279</identifier><identifier>DOI: 10.47162/RJME.62.3.21</identifier><identifier>PMID: 35263412</identifier><language>eng</language><publisher>Romania: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest</publisher><subject>Alleles ; Case Report ; Female ; Humans ; Infertility - complications ; Infertility - genetics ; Pregnancy ; Risk Factors ; Thrombophilia - complications ; Thrombosis - complications</subject><ispartof>Romanian journal of morphology and embryology, 2021-07, Vol.62 (3), p.829-834</ispartof><rights>Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-4e851e942e5ccba6d804bd925c4566e4f5be71ff60265033343909968bf7904f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019663/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019663/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35263412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neamţu, Simona Daniela</creatorcontrib><creatorcontrib>Stanca, Liliana</creatorcontrib><creatorcontrib>Siminel, Mirela Anişoara</creatorcontrib><creatorcontrib>Neamţu, Adela Valeria</creatorcontrib><creatorcontrib>Gluhovschi, Adrian</creatorcontrib><creatorcontrib>Mateescu, Garofiţa Olivia</creatorcontrib><creatorcontrib>Dijmărescu, Anda Lorena</creatorcontrib><creatorcontrib>Săndulescu, Maria Sidonia</creatorcontrib><creatorcontrib>Istrate-Ofiţeru, Anca Maria</creatorcontrib><creatorcontrib>Trăistaru, Magdalena Rodica</creatorcontrib><creatorcontrib>Department of Neonatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><creatorcontrib>Department of Legal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><creatorcontrib>Student, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><creatorcontrib>Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><creatorcontrib>Department of Medical Rehabilitation, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><creatorcontrib>Department of Hematology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><creatorcontrib>Department of Obstetrics and Gynecology, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania</creatorcontrib><creatorcontrib>Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><title>The procoagulant status. Hypercoagulability as a risk factor of primary and secondary infertility</title><title>Romanian journal of morphology and embryology</title><addtitle>Rom J Morphol Embryol</addtitle><description>Thrombophilia is a disorder that makes patients susceptible to intravascular thrombosis that may increase the risk of developing a pregnancy on a known pathology. The female patient diagnosed with hypoplastic uterus and hereditary thrombophilia had a favorable evolution under properly administered anticoagulant treatment. The homozygous status for the C677T mutation may lead to an increase in plasma homocysteine levels, especially in pregnant women, being an associated risk factor for thrombosis. The risk of developing intravascular thrombosis requires primary prevention measures by adding D-dimers in the early diagnostic algorithm, being the most accurate marker of hypercoagulability and endogenous fibrinolysis. The corroboration of the hypercoagulability status with the results of genotyping, the frequencies of the minor/major alleles studied, single mononucleotide polymorphisms (SNPs) and the establishment of preventive therapy, aims to prevent intravascular thrombosis and thromboembolic phenomena.</description><subject>Alleles</subject><subject>Case Report</subject><subject>Female</subject><subject>Humans</subject><subject>Infertility - complications</subject><subject>Infertility - genetics</subject><subject>Pregnancy</subject><subject>Risk Factors</subject><subject>Thrombophilia - complications</subject><subject>Thrombosis - complications</subject><issn>1220-0522</issn><issn>2066-8279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUE1LAzEQDaLYUnv0KvkDu-Z7NxdBilqlIkg9h2w2aVe3m5KkQv-92w-LzmWYefPezDwArjHKWYEFuX1_eX3IBclpTvAZGBIkRFaSQp6DISYEZYgTMgDjGD9RHwJxRItLMKCcCMowGQI9X1q4Dt54vdi0ukswJp02MYfT7dqGY7tq2iZtoY5Qw9DEL-i0ST5A73pus9Khx7oaRmt8V--qpnM2pD3rClw43UY7PuYR-Hh8mE-m2ezt6XlyP8sMLYuUMVtybCUjlhtTaVGXiFW1JNwwLoRljle2wM4JRET_BaWMSiSlKCtXSMQcHYG7g-56U61sbWyXgm7V8T7ldaP-I12zVAv_rSTCUgjaC2QHARN8jMG6Excjtbdb7exWfaaK4H7-5u_C0_SvufQH92l9UA</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Neamţu, Simona Daniela</creator><creator>Stanca, Liliana</creator><creator>Siminel, Mirela Anişoara</creator><creator>Neamţu, Adela Valeria</creator><creator>Gluhovschi, Adrian</creator><creator>Mateescu, Garofiţa Olivia</creator><creator>Dijmărescu, Anda Lorena</creator><creator>Săndulescu, Maria Sidonia</creator><creator>Istrate-Ofiţeru, Anca Maria</creator><creator>Trăistaru, Magdalena Rodica</creator><general>Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20210701</creationdate><title>The procoagulant status. Hypercoagulability as a risk factor of primary and secondary infertility</title><author>Neamţu, Simona Daniela ; Stanca, Liliana ; Siminel, Mirela Anişoara ; Neamţu, Adela Valeria ; Gluhovschi, Adrian ; Mateescu, Garofiţa Olivia ; Dijmărescu, Anda Lorena ; Săndulescu, Maria Sidonia ; Istrate-Ofiţeru, Anca Maria ; Trăistaru, Magdalena Rodica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-4e851e942e5ccba6d804bd925c4566e4f5be71ff60265033343909968bf7904f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alleles</topic><topic>Case Report</topic><topic>Female</topic><topic>Humans</topic><topic>Infertility - complications</topic><topic>Infertility - genetics</topic><topic>Pregnancy</topic><topic>Risk Factors</topic><topic>Thrombophilia - complications</topic><topic>Thrombosis - complications</topic><toplevel>online_resources</toplevel><creatorcontrib>Neamţu, Simona Daniela</creatorcontrib><creatorcontrib>Stanca, Liliana</creatorcontrib><creatorcontrib>Siminel, Mirela Anişoara</creatorcontrib><creatorcontrib>Neamţu, Adela Valeria</creatorcontrib><creatorcontrib>Gluhovschi, Adrian</creatorcontrib><creatorcontrib>Mateescu, Garofiţa Olivia</creatorcontrib><creatorcontrib>Dijmărescu, Anda Lorena</creatorcontrib><creatorcontrib>Săndulescu, Maria Sidonia</creatorcontrib><creatorcontrib>Istrate-Ofiţeru, Anca Maria</creatorcontrib><creatorcontrib>Trăistaru, Magdalena Rodica</creatorcontrib><creatorcontrib>Department of Neonatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><creatorcontrib>Department of Legal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><creatorcontrib>Student, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><creatorcontrib>Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><creatorcontrib>Department of Medical Rehabilitation, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><creatorcontrib>Department of Hematology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><creatorcontrib>Department of Obstetrics and Gynecology, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania</creatorcontrib><creatorcontrib>Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Romanian journal of morphology and embryology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neamţu, Simona Daniela</au><au>Stanca, Liliana</au><au>Siminel, Mirela Anişoara</au><au>Neamţu, Adela Valeria</au><au>Gluhovschi, Adrian</au><au>Mateescu, Garofiţa Olivia</au><au>Dijmărescu, Anda Lorena</au><au>Săndulescu, Maria Sidonia</au><au>Istrate-Ofiţeru, Anca Maria</au><au>Trăistaru, Magdalena Rodica</au><aucorp>Department of Neonatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania</aucorp><aucorp>Department of Legal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania</aucorp><aucorp>Student, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania</aucorp><aucorp>Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania</aucorp><aucorp>Department of Medical Rehabilitation, University of Medicine and Pharmacy of Craiova, Romania</aucorp><aucorp>Department of Hematology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania</aucorp><aucorp>Department of Obstetrics and Gynecology, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania</aucorp><aucorp>Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The procoagulant status. 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The risk of developing intravascular thrombosis requires primary prevention measures by adding D-dimers in the early diagnostic algorithm, being the most accurate marker of hypercoagulability and endogenous fibrinolysis. The corroboration of the hypercoagulability status with the results of genotyping, the frequencies of the minor/major alleles studied, single mononucleotide polymorphisms (SNPs) and the establishment of preventive therapy, aims to prevent intravascular thrombosis and thromboembolic phenomena.</abstract><cop>Romania</cop><pub>Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest</pub><pmid>35263412</pmid><doi>10.47162/RJME.62.3.21</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1220-0522 |
| ispartof | Romanian journal of morphology and embryology, 2021-07, Vol.62 (3), p.829-834 |
| issn | 1220-0522 2066-8279 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9019663 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Alleles Case Report Female Humans Infertility - complications Infertility - genetics Pregnancy Risk Factors Thrombophilia - complications Thrombosis - complications |
| title | The procoagulant status. Hypercoagulability as a risk factor of primary and secondary infertility |
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