Deletion of arylamine N‐acetyltransferase 1 in MDA‐MB‐231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis

Arylamine N‐acetyltransferase 1 (NAT1) is frequently upregulated in breast cancer. Previous studies showed that inhibition or depletion of NAT1 in breast cancer cells diminishes anchorage‐independent growth in culture, suggesting that NAT1 contributes to breast cancer growth and metastasis. To furth...

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Veröffentlicht in:	Molecular carcinogenesis 2022-05, Vol.61 (5), p.481-493
Hauptverfasser:	Doll, Mark A., Ray, Andrew R., Salazar‐González, Raúl A., Shah, Parag P., Vega, Alexis A., Sears, Sophia M., Krueger, Austin M., Hong, Kyung U., Beverly, Levi J., Hein, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferase Animals Apoptosis Arylamine N-Acetyltransferase - genetics Arylamine N-Acetyltransferase - metabolism arylamine N‐acetyltransferase 1 Breast cancer Breast Neoplasms - metabolism Cell culture Cell Line, Tumor Cell migration Female Humans Invasiveness Isoenzymes - metabolism Metastases Metastasis Mice NAT1 Parental behavior tumor Tumor cell lines Tumors xenograft Xenografts
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