Fatty Acid Substitutions Modulate the Cytotoxicity of Puwainaphycins/Minutissamides Isolated from the Baltic Sea Cyanobacterium Nodularia harveyana UHCC-0300

Puwainaphycins (PUW) and minutissamides (MIN) are structurally homologous cyclic lipopeptides that exhibit high structural variability and possess antifungal and cytotoxic activities. While only a minor variation can be found in the amino acid composition of the peptide cycle, the fatty acid (FA) mo...

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Veröffentlicht in:	ACS omega 2022-04, Vol.7 (14), p.11818-11828
Hauptverfasser:	Saurav, Kumar, Caso, Alessia, Urajová, Petra, Hrouzek, Pavel, Esposito, Germana, Delawská, Kateřina, Macho, Markéta, Hájek, Jan, Cheel, José, Saha, Subhasish, Divoká, Petra, Arsin, Sila, Sivonen, Kaarina, Fewer, David P, Costantino, Valeria
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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