Protein synthesis control in cancer: selectivity and therapeutic targeting

Translational control of mRNAs is a point of convergence for many oncogenic signals through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on translational control to appropriately adapt to limited resources while maintaining cell growth and survival, which creates a...

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Veröffentlicht in:	The EMBO journal 2022-04, Vol.41 (8), p.e109823-n/a
Hauptverfasser:	Kovalski, Joanna R, Kuzuoglu‐Ozturk, Duygu, Ruggero, Davide
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Carcinogenesis Cell survival EMBO03 EMBO32 Humans Neoplasms - drug therapy Neoplasms - genetics New technology Nucleotide sequence Protein Biosynthesis Protein synthesis Proteins Review RNA, Messenger - metabolism RNA-binding protein Selectivity Structural members Survival Therapeutic targets Transformed cells Translation translation and protein quality translation inhibitors translational control Tumor Microenvironment Tumorigenesis
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