Palmitic Acid and Oleic Acid Differently Modulate TLR2-Mediated Inflammatory Responses in Microglia and Macrophages

The relationship between systemic immunity and neuroinflammation is widely recognised. Infiltration of peripheral immune cells to the CNS during certain chronic inflammatory states contributes significantly to neuropathology. Obesity and its co-morbidities are primary risk factors for neuroinflammat...

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Veröffentlicht in:	Molecular neurobiology 2022-04, Vol.59 (4), p.2348-2362
Hauptverfasser:	Howe, Anne-Marie, Burke, Sinéad, O’Reilly, Marcella E., McGillicuddy, Fiona C., Costello, Derek A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Biomedical and Life Sciences Biomedicine Cell Biology Cytokines Cytokines - pharmacology Diet Dietary Fats - adverse effects Fatty acids Fatty Acids - pharmacology Fatty Acids, Monounsaturated - pharmacology Humans Inflammation Inflammation - complications Lipoteichoic acid Macrophages Microglia Neurobiology Neurodegenerative diseases Neurology Neurosciences Nitric oxide Nitric Oxide - pharmacology Obesity Obesity - etiology Oleic acid Oleic Acid - pharmacology Palmitic acid Palmitic Acid - pharmacology Risk factors TLR2 protein Toll-Like Receptor 2 Toll-like receptors
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