Estradiol reduces ACE2 and TMPRSS2 mRNA levels in A549 human lung epithelial cells

Epidemiologic studies suggest slightly higher risk of severe Covid‐19 symptoms and fatalities following SARS‐CoV‐2 infection in men compared with women from similar age groups. This bias was suggested to reflect differences in the male and female immune system regulation, driven by different sex hor...

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Veröffentlicht in:	Drug development research 2022-06, Vol.83 (4), p.961-966
Hauptverfasser:	Baristaite, Gabriele, Gurwitz, David
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol A549 lung epithelial cells ACE2 Angiotensin-converting enzyme 2 Cell membranes COVID-19 Epidemiology Epithelial cells Epithelium estrogen replacement therapy Fatalities Furin Gene expression Immune system Infections Lungs Men Mortality Priming Protease Respiratory tract Respiratory tract diseases Serine proteinase Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Sex hormones TMPRSS2 Viral diseases Virions Women
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