SARS-COV-2 - the pandemic of the XXI century, clinical manifestations - neurological implications
In December 2019, in Wuhan, China, the first cases of infection with SARS-CoV 2 responsible for COVID-19 disease were identified. SARS-CoV 2 was declared a pandemic on March 11, 2020, and since then has attracted the medical world's attention. The threat to humans' health that this emergin...
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Veröffentlicht in: | Journal of medicine and life 2022-03, Vol.15 (3), p.319-327 |
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description | In December 2019, in Wuhan, China, the first cases of infection with SARS-CoV 2 responsible for COVID-19 disease were identified. SARS-CoV 2 was declared a pandemic on March 11, 2020, and since then has attracted the medical world's attention. The threat to humans' health that this emerging pandemic could leave raises awareness on the importance of understanding the mechanisms that underlie the developing conditions. The epidemiology, clinical picture, and pathogenesis of COVID-19 show that this virus presents new strategies to overcome the past defensive medicine. While all the current data has focused on the pulmonary and cardiovascular manifestations, little has been written about the neurological implications of the disease. This review updates new clinical aspects that SARS-CoV 2 expresses in humans by focusing primarily on neurological manifestations. The damage to the nervous system became more apparent - anosmia, ageusia, polyneuritis, meningitis, meningoencephalitis, stroke, acute necrotizing encephalopathy. Oxygen therapy is vital for those in critical health situations. Finally, prevention is the most important element in breaking the epidemiological chain. |
doi_str_mv | 10.25122/jml-2020-0151 |
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E-mail: moreanumihai@yahoo.com ; Department of Neurosurgery, County Emergency Hospital, Sibiu, Romania ; Department of Neurosurgery, County Emergency Hospital, Oradea, Romania ; Department of Neurosurgery, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania ; Department of Neurosurgery, Faculty of Medicine, Lucian Blaga University, Sibiu, Romania ; Department of Neurosurgery, Sanador Clinical Hospital, Bucharest, Romania</creatorcontrib><description>In December 2019, in Wuhan, China, the first cases of infection with SARS-CoV 2 responsible for COVID-19 disease were identified. SARS-CoV 2 was declared a pandemic on March 11, 2020, and since then has attracted the medical world's attention. The threat to humans' health that this emerging pandemic could leave raises awareness on the importance of understanding the mechanisms that underlie the developing conditions. The epidemiology, clinical picture, and pathogenesis of COVID-19 show that this virus presents new strategies to overcome the past defensive medicine. While all the current data has focused on the pulmonary and cardiovascular manifestations, little has been written about the neurological implications of the disease. This review updates new clinical aspects that SARS-CoV 2 expresses in humans by focusing primarily on neurological manifestations. The damage to the nervous system became more apparent - anosmia, ageusia, polyneuritis, meningitis, meningoencephalitis, stroke, acute necrotizing encephalopathy. Oxygen therapy is vital for those in critical health situations. Finally, prevention is the most important element in breaking the epidemiological chain.</description><identifier>ISSN: 1844-122X</identifier><identifier>EISSN: 1844-3117</identifier><identifier>DOI: 10.25122/jml-2020-0151</identifier><identifier>PMID: 35450003</identifier><language>eng</language><publisher>Romania: Carol Daila University Foundation</publisher><subject>Coronaviruses ; COVID-19 ; Epidemics ; Fatalities ; Humans ; Nervous System Diseases - epidemiology ; Nervous System Diseases - etiology ; Pandemics ; Review ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Stroke - complications</subject><ispartof>Journal of medicine and life, 2022-03, Vol.15 (3), p.319-327</ispartof><rights>Carol Davila University Press.</rights><rights>Copyright Carol Daila University Foundation Mar 2022</rights><rights>Carol Davila University Press 2022</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3331-979895d7d693852dd592be731059a32f44eea1fe095f06756e21f266e4c9817b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015186/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015186/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35450003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saceleanu, Vicentiu</creatorcontrib><creatorcontrib>Moreanu, Mihai-Stelian</creatorcontrib><creatorcontrib>Covache-Busuioc, Razvan-Adrian</creatorcontrib><creatorcontrib>Mohan, Aurel George</creatorcontrib><creatorcontrib>Ciurea, Alexandru-Vlad</creatorcontrib><creatorcontrib>Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania</creatorcontrib><creatorcontrib>Mihai-Stelian Moreanu, Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. E-mail: moreanumihai@yahoo.com</creatorcontrib><creatorcontrib>Department of Neurosurgery, County Emergency Hospital, Sibiu, Romania</creatorcontrib><creatorcontrib>Department of Neurosurgery, County Emergency Hospital, Oradea, Romania</creatorcontrib><creatorcontrib>Department of Neurosurgery, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania</creatorcontrib><creatorcontrib>Department of Neurosurgery, Faculty of Medicine, Lucian Blaga University, Sibiu, Romania</creatorcontrib><creatorcontrib>Department of Neurosurgery, Sanador Clinical Hospital, Bucharest, Romania</creatorcontrib><title>SARS-COV-2 - the pandemic of the XXI century, clinical manifestations - neurological implications</title><title>Journal of medicine and life</title><addtitle>J Med Life</addtitle><description>In December 2019, in Wuhan, China, the first cases of infection with SARS-CoV 2 responsible for COVID-19 disease were identified. SARS-CoV 2 was declared a pandemic on March 11, 2020, and since then has attracted the medical world's attention. The threat to humans' health that this emerging pandemic could leave raises awareness on the importance of understanding the mechanisms that underlie the developing conditions. The epidemiology, clinical picture, and pathogenesis of COVID-19 show that this virus presents new strategies to overcome the past defensive medicine. While all the current data has focused on the pulmonary and cardiovascular manifestations, little has been written about the neurological implications of the disease. This review updates new clinical aspects that SARS-CoV 2 expresses in humans by focusing primarily on neurological manifestations. The damage to the nervous system became more apparent - anosmia, ageusia, polyneuritis, meningitis, meningoencephalitis, stroke, acute necrotizing encephalopathy. Oxygen therapy is vital for those in critical health situations. Finally, prevention is the most important element in breaking the epidemiological chain.</description><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Epidemics</subject><subject>Fatalities</subject><subject>Humans</subject><subject>Nervous System Diseases - epidemiology</subject><subject>Nervous System Diseases - etiology</subject><subject>Pandemics</subject><subject>Review</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Stroke - complications</subject><issn>1844-122X</issn><issn>1844-3117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdUU1LAzEUDKKoVK8eZcGLB1PzscluLoIUPwqC4Be9hXQ3qynZpCZdof_ebFuLmhzyHjNveJMB4ASjIWGYkMtZayFBBEGEGd4Bh7jMc0gxLnY3dSJNDsBxjDOUTs4453QfHFCWs9TTQ6Cer5-e4ejxDZIMZosPnc2Vq3Vrqsw3q34yGWeVdosuLC-yyhpnKmWzVjnT6LhQC-NdTKNOd8Fb_75CTTu3qVhhR2CvUTbq4807AK-3Ny-je_jweDceXT_AilKKoShEKVhd1FzQkpG6ZoJMdUExYkJR0uS51go3GgnWIF4wrgluCOc6r0SJiykdgKu17rybtrruVw7KynkwrQpL6ZWRfxFnPuS7_5Ki_7ySJ4HzjUDwn13yJlsTK22tctp3URLOclIiQXrq2T_qzHfBJXuJxRkuaH8HYLhmVcHHGHSzXQYjuQpQpgBlH6Dsd0gDp78tbOk_cdFvS7aUug</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Saceleanu, Vicentiu</creator><creator>Moreanu, Mihai-Stelian</creator><creator>Covache-Busuioc, Razvan-Adrian</creator><creator>Mohan, Aurel George</creator><creator>Ciurea, Alexandru-Vlad</creator><general>Carol Daila University Foundation</general><general>Carol Davila University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220301</creationdate><title>SARS-COV-2 - the pandemic of the XXI century, clinical manifestations - neurological implications</title><author>Saceleanu, Vicentiu ; Moreanu, Mihai-Stelian ; Covache-Busuioc, Razvan-Adrian ; Mohan, Aurel George ; Ciurea, Alexandru-Vlad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3331-979895d7d693852dd592be731059a32f44eea1fe095f06756e21f266e4c9817b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Epidemics</topic><topic>Fatalities</topic><topic>Humans</topic><topic>Nervous System Diseases - epidemiology</topic><topic>Nervous System Diseases - etiology</topic><topic>Pandemics</topic><topic>Review</topic><topic>SARS-CoV-2</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Stroke - complications</topic><toplevel>online_resources</toplevel><creatorcontrib>Saceleanu, Vicentiu</creatorcontrib><creatorcontrib>Moreanu, Mihai-Stelian</creatorcontrib><creatorcontrib>Covache-Busuioc, Razvan-Adrian</creatorcontrib><creatorcontrib>Mohan, Aurel George</creatorcontrib><creatorcontrib>Ciurea, Alexandru-Vlad</creatorcontrib><creatorcontrib>Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania</creatorcontrib><creatorcontrib>Mihai-Stelian Moreanu, Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. 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SARS-CoV 2 was declared a pandemic on March 11, 2020, and since then has attracted the medical world's attention. The threat to humans' health that this emerging pandemic could leave raises awareness on the importance of understanding the mechanisms that underlie the developing conditions. The epidemiology, clinical picture, and pathogenesis of COVID-19 show that this virus presents new strategies to overcome the past defensive medicine. While all the current data has focused on the pulmonary and cardiovascular manifestations, little has been written about the neurological implications of the disease. This review updates new clinical aspects that SARS-CoV 2 expresses in humans by focusing primarily on neurological manifestations. The damage to the nervous system became more apparent - anosmia, ageusia, polyneuritis, meningitis, meningoencephalitis, stroke, acute necrotizing encephalopathy. Oxygen therapy is vital for those in critical health situations. 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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
subjects | Coronaviruses COVID-19 Epidemics Fatalities Humans Nervous System Diseases - epidemiology Nervous System Diseases - etiology Pandemics Review SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Stroke - complications |
title | SARS-COV-2 - the pandemic of the XXI century, clinical manifestations - neurological implications |
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