Inactivating Celsr2 promotes motor axon fasciculation and regeneration in mouse and human

Understanding new modulators of axon regeneration is central to neural repair. Our previous work demonstrated critical roles of atypical cadherin Celsr2 during neural development, including cilia organization, neuron migration and axon navigation. Here, we address its role in axon regeneration. We s...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2022-04, Vol.145 (2), p.670-683
Hauptverfasser:	Wen, Quan, Weng, Huandi, Liu, Tao, Yu, Lingtai, Zhao, Tianyun, Qin, Jingwen, Li, Si, Wu, Qingfeng, Tissir, Fadel, Qu, Yibo, Zhou, Libing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axon Fasciculation Axons - metabolism Cadherins Humans Mice Motor Neurons - metabolism Nerve Regeneration Original Spinal Cord Spinal Cord Injuries - metabolism
Online-Zugang:	Volltext
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