Hydroxamate and thiosemicarbazone: Two highly promising scaffolds for the development of SARS-CoV-2 antivirals

[Display omitted] •The main protease (Mpro) of SARS-CoV-2 is promising target for antiviral drugs to combat COVID-19;•The hydroxamates and thiosemicarbazones effectively inhibited Mpro with an IC50 in range of 0.12–34.22 μM;•The hydroxamates irreversibly, but thiosemicarbazones reversibly and compet...

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Veröffentlicht in:	Bioorganic chemistry 2022-07, Vol.124, p.105799-105799, Article 105799
Hauptverfasser:	Xu, Yin-Sui, Chigan, Jia-Zhu, Li, Jia-Qi, Ding, Huan-Huan, Sun, Le-Yun, Liu, Lu, Hu, Zhenxin, Yang, Ke-Wu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - chemistry Coronavirus 3C Proteases COVID-19 Drug Treatment Humans Hydroxamates Inhibitor Main protease Mice Molecular Docking Simulation Pandemics Protease Inhibitors - chemistry SARS-CoV-2 Thiosemicarbazones Thiosemicarbazones - pharmacology
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