Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines

Antimicrobial drug resistance is a looming health crisis facing us in the modern era, and new drugs are urgently needed to combat this growing problem. Synthetic mimics of antimicrobial peptides have recently emerged as a promising class of compounds for the treatment of persistent microbial infecti...

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Veröffentlicht in:ACS medicinal chemistry letters 2022-04, Vol.13 (4), p.632-640
Hauptverfasser: Grant, Thomas M, Rennison, David, Krause, Alexandra L, Mros, Sonya, Ferguson, Scott A, Cook, Gregory M, Cameron, Alan, Arabshahi, Homayon J, Brimble, Margaret A, Cahill, Patrick, Svenson, Johan
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