α4β2 Nicotinic Cholinergic Receptor Target Engagement in Parkinson Disease Gait–Balance Disorders

Objective Attentional deficits following degeneration of brain cholinergic systems contribute to gait–balance deficits in Parkinson disease (PD). As a step toward assessing whether α4β2* nicotinic acetylcholine receptor (nAChR) stimulation improves gait–balance function, we assessed target engagemen...

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Veröffentlicht in:	Annals of neurology 2021-07, Vol.90 (1), p.130-142
Hauptverfasser:	Albin, Roger L., Müller, Martijn L. T. M., Bohnen, Nicolaas I., Spino, Cathie, Sarter, Martin, Koeppe, Robert A., Szpara, Ashley, Kim, Kamin, Lustig, Cindy, Dauer, William T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors Acetylcholine receptors (nicotinic) Aged Agonists Balance Brain - diagnostic imaging Cholinergics Cognition Cross-Over Studies Degeneration Disorders Dosage Female Fluorine isotopes Gait Gait - drug effects Gait Disorders, Neurologic - diagnostic imaging Gait Disorders, Neurologic - drug therapy Humans Male Middle Aged Movement disorders Neurodegeneration Neurodegenerative diseases Nicotinic Agonists - pharmacology Nicotinic Agonists - therapeutic use Occupancy Parkinson Disease - diagnostic imaging Parkinson Disease - drug therapy Parkinson's disease Placebos Positron emission Positron emission tomography Postural Balance - drug effects Posture Receptors Stability Tomography Varenicline - pharmacology Varenicline - therapeutic use
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