Opening of the Blood-Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models

The blood-brain barrier (BBB) inhibits adequate dosing/penetration of therapeutic agents to malignancies in the brain. Low-intensity pulsed ultrasound (LIPU) is a safe therapeutic method of temporary BBB disruption (BBBD) to enhance chemotherapeutic delivery to the tumor and surrounding brain parenc...

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Veröffentlicht in:	Clinical cancer research 2021-08, Vol.27 (15), p.4325-4337
Hauptverfasser:	Sabbagh, Aria, Beccaria, Kevin, Ling, Xiaoyang, Marisetty, Anantha, Ott, Martina, Caruso, Hillary, Barton, Emily, Kong, Ling-Yuan, Fang, Dexing, Latha, Khatri, Zhang, Daniel Yang, Wei, Jun, DeGroot, John, Curran, Michael A, Rao, Ganesh, Hu, Jian, Desseaux, Carole, Bouchoux, Guillaume, Canney, Michael, Carpentier, Alexandre, Heimberger, Amy B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - radiation effects Brain Neoplasms - therapy Disease Models, Animal Glioma - therapy Human health and pathology Immunotherapy Life Sciences Mice Mice, Inbred C57BL Treatment Outcome Ultrasonic Waves
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