PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay

PI5P4Ks are a class of phosphoinositide kinases that phosphorylate PI-5-P to PI-4,5-P2. Distinct localization of phosphoinositides is fundamental for a multitude of cellular functions. Here, we identify a role for peroxisomal PI-4,5-P2 generated by the PI5P4Ks in maintaining energy balance. We demon...

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Veröffentlicht in:	Developmental cell 2021-06, Vol.56 (11), p.1661-1676.e10
Hauptverfasser:	Ravi, Archna, Palamiuc, Lavinia, Loughran, Ryan M., Triscott, Joanna, Arora, Gurpreet K., Kumar, Avi, Tieu, Vivian, Pauli, Chantal, Reist, Matthias, Lew, Rachel J., Houlihan, Shauna L., Fellmann, Christof, Metallo, Christian, Rubin, Mark A., Emerling, Brooke M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cancer Carcinogenesis - genetics Cell Line, Tumor Energy Metabolism - genetics fatty acid Female Homeostasis - genetics Humans lipid lipid droplet Lipid Droplets - metabolism Lipid Metabolism - genetics Male metabolism Mice mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondria - ultrastructure Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology peroxisome Peroxisomes - genetics Peroxisomes - metabolism phosphoinositide phosphoinositide kinase Phosphotransferases (Alcohol Group Acceptor) - genetics PI-4,5-P2 PI-5-P PI5P4Ks sarcoma β-oxidation
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