The Sertoli cell expressed gene secernin‐1 (Scrn1) is dispensable for male fertility in the mouse

Background Male infertility is a prevalent clinical presentation for which there is likely a strong genetic component due to the thousands of genes required for spermatogenesis. Within this study we investigated the role of the gene Scrn1 in male fertility. Scrn1 is preferentially expressed in XY go...

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Veröffentlicht in:	Developmental dynamics 2021-07, Vol.250 (7), p.922-931
Hauptverfasser:	Houston, Brendan J., Nagirnaja, Liina, Merriner, D. Jo, O'Connor, Anne E., Okuda, Hidenobu, Omurtag, Kenan, Smith, Craig, Aston, Kenneth I., Conrad, Donald F., O'Bryan, Moira K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Clonal deletion Cytoplasm Embryo, Mammalian Female Fertility Fertility - genetics Gene expression Gene sequencing Gonads Infertility Infertility, Male - genetics Infertility, Male - metabolism Male Males Mice Mice, Inbred C57BL Mice, Knockout Model testing Morphology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Physical characteristics Pregnancy Rodents sertoli cell Sertoli cells Sertoli Cells - metabolism Sertoli Cells - physiology Sex Sex determination sex development Spermatogenesis Spermatogenesis - genetics Testis - metabolism
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