Using Chitosan-Coated Polymeric Nanoparticles-Thermosensitive Hydrogels in association with Limonene as Skin Drug Delivery Strategy

Topical delivery of local anesthetics (LAs) is commonly used to decrease painful sensations, block pain throughout procedures, and alleviate pain after surgery. Dermal and/or transdermal delivery of LAs has other advantages, such as sustained drug delivery and decreased systemic adverse effects. Thi...

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Veröffentlicht in:	BioMed research international 2022-04, Vol.2022, p.9165443-18
Hauptverfasser:	Campos, Estefânia V. R., Proença, Patrícia L. F., da Costa, Tais G., de Lima, Renata, Fraceto, Leonardo F., de Araujo, Daniele R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthetics Anesthetics, Local Benzocaine Cell viability Chitin Chitosan Coatings Colloids Controlled release Dermatologic agents Dermatology Dosage and administration Drug Carriers Drug delivery Drug Delivery Systems Drug Liberation Drugs Efficiency Fibroblasts Formulae, receipts, prescriptions Hybrids Hydrogels Keratinocytes Limonene Local anesthetics Morphology Nanoparticles Pain Particle Size Penetration Permeability Pharmaceutical research Poloxamers Polylactide-co-glycolide Polymers Production processes Pseudoplasticity Scanning electron microscopy Skin Sustained release Toxicity Vehicles Viscosity Zeta potential
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