Regional age-related atrophy after screening for preclinical alzheimer disease
•Regional age-related atrophy varies in strength and pattern.•Non-linear pattern of age-related atrophy correlates with T1/T2 myelin content.•Additional atrophy not seen in preclinical Alzheimer disease. Brain atrophy occurs in aging even in the absence of dementia, but it is unclear to what extent...
Gespeichert in:
| Veröffentlicht in: | Neurobiology of aging 2022-01, Vol.109, p.43-51 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 51 |
|---|---|
| container_issue | |
| container_start_page | 43 |
| container_title | Neurobiology of aging |
| container_volume | 109 |
| creator | Koenig, Lauren N. LaMontagne, Pamela Glasser, Matthew F. Bateman, Randall Holtzman, David Yakushev, Igor Chhatwal, Jasmeer Day, Gregory S Jack, Clifford Mummery, Catherine Perrin, Richard J. Gordon, Brian A. Morris, John C. Shimony, Joshua S. Benzinger, Tammie L.S. |
| description | •Regional age-related atrophy varies in strength and pattern.•Non-linear pattern of age-related atrophy correlates with T1/T2 myelin content.•Additional atrophy not seen in preclinical Alzheimer disease.
Brain atrophy occurs in aging even in the absence of dementia, but it is unclear to what extent this is due to undetected preclinical Alzheimer disease. Here we examine a cross-sectional cohort (ages 18-88) free from confounding influence of preclinical Alzheimer disease, as determined by amyloid PET scans and three years of clinical evaluation post-imaging. We determine the regional strength of age-related atrophy using linear modeling of brain volumes and cortical thicknesses with age. Age-related atrophy was seen in nearly all regions, with greatest effects in the temporal lobe and subcortical regions. When modeling age with the estimated derivative of smoothed aging curves, we found that the temporal lobe declined linearly with age, subcortical regions declined faster at later ages, and frontal regions declined slower at later ages than during midlife. This age-derivative pattern was distinct from the linear measure of age-related atrophy and significantly associated with a measure of myelin. Atrophy did not detectably differ from a preclinical Alzheimer disease cohort when age ranges were matched. |
| doi_str_mv | 10.1016/j.neurobiolaging.2021.09.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9009406</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0197458021002918</els_id><sourcerecordid>2582806991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-48a591fafee56c49edae7479f734206d2d05892ae84507cd99472cc515f265993</originalsourceid><addsrcrecordid>eNqNkd9rFDEQx4Mo9qz-C7IPPviy6ySX7O6ACFKsCkVB9DmkyexejlxyJnuF9q83x9Vi33wKTL4_hvkw9oZDx4H377ZdpENO1z4FM_s4dwIE7wA74PCErbhSY8slDk_ZCjgOrVQjnLEXpWwBYJBD_5ydrWWvFI6wYt9-0OxTNKExM7WZglnINWbJab-5bcy0UG6KzUSxVjVTys0-kw0-env0hLsN-V3VOF_IFHrJnk0mFHp1_56zX5effl58aa--f_568fGqtRLV0srRKOSTmYhUX0fkDNXVcBrWUkDvhAM1ojA0SgWDdYhyENYqribRK8T1Oftwyt0frnfkLMUlm6D32e9MvtXJeP34J_qNntONRgCU0NeAt_cBOf0-UFn0zhdLIZhI6VC0UKMYoUfkVfr-JLU5lZJpeqjhoI9I9FY_RqKPSDSgrkiq_fW_qz6Y_zKogsuTgOrBbjxlXaynaMn5eupFu-T_r-kPXDaoBA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2582806991</pqid></control><display><type>article</type><title>Regional age-related atrophy after screening for preclinical alzheimer disease</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Koenig, Lauren N. ; LaMontagne, Pamela ; Glasser, Matthew F. ; Bateman, Randall ; Holtzman, David ; Yakushev, Igor ; Chhatwal, Jasmeer ; Day, Gregory S ; Jack, Clifford ; Mummery, Catherine ; Perrin, Richard J. ; Gordon, Brian A. ; Morris, John C. ; Shimony, Joshua S. ; Benzinger, Tammie L.S.</creator><creatorcontrib>Koenig, Lauren N. ; LaMontagne, Pamela ; Glasser, Matthew F. ; Bateman, Randall ; Holtzman, David ; Yakushev, Igor ; Chhatwal, Jasmeer ; Day, Gregory S ; Jack, Clifford ; Mummery, Catherine ; Perrin, Richard J. ; Gordon, Brian A. ; Morris, John C. ; Shimony, Joshua S. ; Benzinger, Tammie L.S. ; Dominantly Inherited Alzheimer Network (DIAN)</creatorcontrib><description>•Regional age-related atrophy varies in strength and pattern.•Non-linear pattern of age-related atrophy correlates with T1/T2 myelin content.•Additional atrophy not seen in preclinical Alzheimer disease.
Brain atrophy occurs in aging even in the absence of dementia, but it is unclear to what extent this is due to undetected preclinical Alzheimer disease. Here we examine a cross-sectional cohort (ages 18-88) free from confounding influence of preclinical Alzheimer disease, as determined by amyloid PET scans and three years of clinical evaluation post-imaging. We determine the regional strength of age-related atrophy using linear modeling of brain volumes and cortical thicknesses with age. Age-related atrophy was seen in nearly all regions, with greatest effects in the temporal lobe and subcortical regions. When modeling age with the estimated derivative of smoothed aging curves, we found that the temporal lobe declined linearly with age, subcortical regions declined faster at later ages, and frontal regions declined slower at later ages than during midlife. This age-derivative pattern was distinct from the linear measure of age-related atrophy and significantly associated with a measure of myelin. Atrophy did not detectably differ from a preclinical Alzheimer disease cohort when age ranges were matched.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2021.09.010</identifier><identifier>PMID: 34655980</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging - pathology ; Alzheimer Disease - diagnosis ; Alzheimer Disease - pathology ; Atrophy ; Brain - diagnostic imaging ; Brain - metabolism ; Brain - pathology ; Cross-Sectional Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Imaging (MRI) ; Male ; Middle Aged ; Myelin Sheath - metabolism ; Normal Aging ; Positron-Emission Tomography ; Preclinical Alzheimer disease ; Volumetrics ; Young Adult</subject><ispartof>Neurobiology of aging, 2022-01, Vol.109, p.43-51</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-48a591fafee56c49edae7479f734206d2d05892ae84507cd99472cc515f265993</citedby><cites>FETCH-LOGICAL-c495t-48a591fafee56c49edae7479f734206d2d05892ae84507cd99472cc515f265993</cites><orcidid>0000-0002-8114-0552 ; 0000-0002-6228-776X ; 0000-0001-7916-622X ; 0000-0002-3443-7716 ; 0000-0002-6752-8518 ; 0000-0003-2279-4510 ; 0000-0002-3400-0856 ; 0000-0001-5133-5538</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0197458021002918$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34655980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koenig, Lauren N.</creatorcontrib><creatorcontrib>LaMontagne, Pamela</creatorcontrib><creatorcontrib>Glasser, Matthew F.</creatorcontrib><creatorcontrib>Bateman, Randall</creatorcontrib><creatorcontrib>Holtzman, David</creatorcontrib><creatorcontrib>Yakushev, Igor</creatorcontrib><creatorcontrib>Chhatwal, Jasmeer</creatorcontrib><creatorcontrib>Day, Gregory S</creatorcontrib><creatorcontrib>Jack, Clifford</creatorcontrib><creatorcontrib>Mummery, Catherine</creatorcontrib><creatorcontrib>Perrin, Richard J.</creatorcontrib><creatorcontrib>Gordon, Brian A.</creatorcontrib><creatorcontrib>Morris, John C.</creatorcontrib><creatorcontrib>Shimony, Joshua S.</creatorcontrib><creatorcontrib>Benzinger, Tammie L.S.</creatorcontrib><creatorcontrib>Dominantly Inherited Alzheimer Network (DIAN)</creatorcontrib><title>Regional age-related atrophy after screening for preclinical alzheimer disease</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>•Regional age-related atrophy varies in strength and pattern.•Non-linear pattern of age-related atrophy correlates with T1/T2 myelin content.•Additional atrophy not seen in preclinical Alzheimer disease.
Brain atrophy occurs in aging even in the absence of dementia, but it is unclear to what extent this is due to undetected preclinical Alzheimer disease. Here we examine a cross-sectional cohort (ages 18-88) free from confounding influence of preclinical Alzheimer disease, as determined by amyloid PET scans and three years of clinical evaluation post-imaging. We determine the regional strength of age-related atrophy using linear modeling of brain volumes and cortical thicknesses with age. Age-related atrophy was seen in nearly all regions, with greatest effects in the temporal lobe and subcortical regions. When modeling age with the estimated derivative of smoothed aging curves, we found that the temporal lobe declined linearly with age, subcortical regions declined faster at later ages, and frontal regions declined slower at later ages than during midlife. This age-derivative pattern was distinct from the linear measure of age-related atrophy and significantly associated with a measure of myelin. Atrophy did not detectably differ from a preclinical Alzheimer disease cohort when age ranges were matched.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - pathology</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - pathology</subject><subject>Atrophy</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Imaging (MRI)</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myelin Sheath - metabolism</subject><subject>Normal Aging</subject><subject>Positron-Emission Tomography</subject><subject>Preclinical Alzheimer disease</subject><subject>Volumetrics</subject><subject>Young Adult</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd9rFDEQx4Mo9qz-C7IPPviy6ySX7O6ACFKsCkVB9DmkyexejlxyJnuF9q83x9Vi33wKTL4_hvkw9oZDx4H377ZdpENO1z4FM_s4dwIE7wA74PCErbhSY8slDk_ZCjgOrVQjnLEXpWwBYJBD_5ydrWWvFI6wYt9-0OxTNKExM7WZglnINWbJab-5bcy0UG6KzUSxVjVTys0-kw0-env0hLsN-V3VOF_IFHrJnk0mFHp1_56zX5effl58aa--f_568fGqtRLV0srRKOSTmYhUX0fkDNXVcBrWUkDvhAM1ojA0SgWDdYhyENYqribRK8T1Oftwyt0frnfkLMUlm6D32e9MvtXJeP34J_qNntONRgCU0NeAt_cBOf0-UFn0zhdLIZhI6VC0UKMYoUfkVfr-JLU5lZJpeqjhoI9I9FY_RqKPSDSgrkiq_fW_qz6Y_zKogsuTgOrBbjxlXaynaMn5eupFu-T_r-kPXDaoBA</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Koenig, Lauren N.</creator><creator>LaMontagne, Pamela</creator><creator>Glasser, Matthew F.</creator><creator>Bateman, Randall</creator><creator>Holtzman, David</creator><creator>Yakushev, Igor</creator><creator>Chhatwal, Jasmeer</creator><creator>Day, Gregory S</creator><creator>Jack, Clifford</creator><creator>Mummery, Catherine</creator><creator>Perrin, Richard J.</creator><creator>Gordon, Brian A.</creator><creator>Morris, John C.</creator><creator>Shimony, Joshua S.</creator><creator>Benzinger, Tammie L.S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8114-0552</orcidid><orcidid>https://orcid.org/0000-0002-6228-776X</orcidid><orcidid>https://orcid.org/0000-0001-7916-622X</orcidid><orcidid>https://orcid.org/0000-0002-3443-7716</orcidid><orcidid>https://orcid.org/0000-0002-6752-8518</orcidid><orcidid>https://orcid.org/0000-0003-2279-4510</orcidid><orcidid>https://orcid.org/0000-0002-3400-0856</orcidid><orcidid>https://orcid.org/0000-0001-5133-5538</orcidid></search><sort><creationdate>20220101</creationdate><title>Regional age-related atrophy after screening for preclinical alzheimer disease</title><author>Koenig, Lauren N. ; LaMontagne, Pamela ; Glasser, Matthew F. ; Bateman, Randall ; Holtzman, David ; Yakushev, Igor ; Chhatwal, Jasmeer ; Day, Gregory S ; Jack, Clifford ; Mummery, Catherine ; Perrin, Richard J. ; Gordon, Brian A. ; Morris, John C. ; Shimony, Joshua S. ; Benzinger, Tammie L.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-48a591fafee56c49edae7479f734206d2d05892ae84507cd99472cc515f265993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - pathology</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - pathology</topic><topic>Atrophy</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Imaging (MRI)</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myelin Sheath - metabolism</topic><topic>Normal Aging</topic><topic>Positron-Emission Tomography</topic><topic>Preclinical Alzheimer disease</topic><topic>Volumetrics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koenig, Lauren N.</creatorcontrib><creatorcontrib>LaMontagne, Pamela</creatorcontrib><creatorcontrib>Glasser, Matthew F.</creatorcontrib><creatorcontrib>Bateman, Randall</creatorcontrib><creatorcontrib>Holtzman, David</creatorcontrib><creatorcontrib>Yakushev, Igor</creatorcontrib><creatorcontrib>Chhatwal, Jasmeer</creatorcontrib><creatorcontrib>Day, Gregory S</creatorcontrib><creatorcontrib>Jack, Clifford</creatorcontrib><creatorcontrib>Mummery, Catherine</creatorcontrib><creatorcontrib>Perrin, Richard J.</creatorcontrib><creatorcontrib>Gordon, Brian A.</creatorcontrib><creatorcontrib>Morris, John C.</creatorcontrib><creatorcontrib>Shimony, Joshua S.</creatorcontrib><creatorcontrib>Benzinger, Tammie L.S.</creatorcontrib><creatorcontrib>Dominantly Inherited Alzheimer Network (DIAN)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koenig, Lauren N.</au><au>LaMontagne, Pamela</au><au>Glasser, Matthew F.</au><au>Bateman, Randall</au><au>Holtzman, David</au><au>Yakushev, Igor</au><au>Chhatwal, Jasmeer</au><au>Day, Gregory S</au><au>Jack, Clifford</au><au>Mummery, Catherine</au><au>Perrin, Richard J.</au><au>Gordon, Brian A.</au><au>Morris, John C.</au><au>Shimony, Joshua S.</au><au>Benzinger, Tammie L.S.</au><aucorp>Dominantly Inherited Alzheimer Network (DIAN)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional age-related atrophy after screening for preclinical alzheimer disease</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>109</volume><spage>43</spage><epage>51</epage><pages>43-51</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>•Regional age-related atrophy varies in strength and pattern.•Non-linear pattern of age-related atrophy correlates with T1/T2 myelin content.•Additional atrophy not seen in preclinical Alzheimer disease.
Brain atrophy occurs in aging even in the absence of dementia, but it is unclear to what extent this is due to undetected preclinical Alzheimer disease. Here we examine a cross-sectional cohort (ages 18-88) free from confounding influence of preclinical Alzheimer disease, as determined by amyloid PET scans and three years of clinical evaluation post-imaging. We determine the regional strength of age-related atrophy using linear modeling of brain volumes and cortical thicknesses with age. Age-related atrophy was seen in nearly all regions, with greatest effects in the temporal lobe and subcortical regions. When modeling age with the estimated derivative of smoothed aging curves, we found that the temporal lobe declined linearly with age, subcortical regions declined faster at later ages, and frontal regions declined slower at later ages than during midlife. This age-derivative pattern was distinct from the linear measure of age-related atrophy and significantly associated with a measure of myelin. Atrophy did not detectably differ from a preclinical Alzheimer disease cohort when age ranges were matched.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34655980</pmid><doi>10.1016/j.neurobiolaging.2021.09.010</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8114-0552</orcidid><orcidid>https://orcid.org/0000-0002-6228-776X</orcidid><orcidid>https://orcid.org/0000-0001-7916-622X</orcidid><orcidid>https://orcid.org/0000-0002-3443-7716</orcidid><orcidid>https://orcid.org/0000-0002-6752-8518</orcidid><orcidid>https://orcid.org/0000-0003-2279-4510</orcidid><orcidid>https://orcid.org/0000-0002-3400-0856</orcidid><orcidid>https://orcid.org/0000-0001-5133-5538</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-4580 |
| ispartof | Neurobiology of aging, 2022-01, Vol.109, p.43-51 |
| issn | 0197-4580 1558-1497 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9009406 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Aging - pathology Alzheimer Disease - diagnosis Alzheimer Disease - pathology Atrophy Brain - diagnostic imaging Brain - metabolism Brain - pathology Cross-Sectional Studies Female Humans Magnetic Resonance Imaging Magnetic Resonance Imaging (MRI) Male Middle Aged Myelin Sheath - metabolism Normal Aging Positron-Emission Tomography Preclinical Alzheimer disease Volumetrics Young Adult |
| title | Regional age-related atrophy after screening for preclinical alzheimer disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T13%3A45%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regional%20age-related%20atrophy%20after%20screening%20for%20preclinical%20alzheimer%20disease&rft.jtitle=Neurobiology%20of%20aging&rft.au=Koenig,%20Lauren%20N.&rft.aucorp=Dominantly%20Inherited%20Alzheimer%20Network%20(DIAN)&rft.date=2022-01-01&rft.volume=109&rft.spage=43&rft.epage=51&rft.pages=43-51&rft.issn=0197-4580&rft.eissn=1558-1497&rft_id=info:doi/10.1016/j.neurobiolaging.2021.09.010&rft_dat=%3Cproquest_pubme%3E2582806991%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2582806991&rft_id=info:pmid/34655980&rft_els_id=S0197458021002918&rfr_iscdi=true |